AutismKB 2.0

Annotation Detail for SCN1B


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Basic Information Top
Gene Symbol:SCN1B ( GEFSP1 )
Gene Full Name: sodium channel, voltage-gated, type I, beta
Band: 19q13.11
Quick LinksEntrez ID:6324; OMIM: 600235; Uniprot ID:SCN1B_HUMAN; ENSEMBL ID: ENSG00000105711; HGNC ID: 10586
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1799Epilepsy
2120Rabies
Desease Name
epilepsy
NEUROLOGICAL
No data
Desease Name
Cardiac conduction defect, nonspecific
Brugada syndrome 5
Generalized epilepsy with febrile seizures plus
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SCN1B mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of SCN1B mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in decreased expression of SCN1B mRNAdecreases expression 15520326
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCN1B mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in increased expression of SCN1B mRNAincreases expression 17103032
D001241 Aspirin Aspirin results in increased expression of SCN1B mRNAincreases expression 11906190
D003314 Corn Oil Corn Oil affects the expression of SCN1B mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of SCN1B mRNAdecreases expression 20106945
C052570 cyfluthrin cyfluthrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017160 cypermethrin cypermethrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017160 cypermethrin SCN1B protein promotes the reaction [cypermethrin binds to SCN2A1 protein]affects binding|increases reaction 9863771
C044267 fenpropathrin fenpropathrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017690 fenvalerate fenvalerate affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C010176 halofuginone halofuginone results in decreased expression of SCN1B mRNAdecreases expression 17180598
D012964 Sodium cyfluthrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium cypermethrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium fenpropathrin affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium fenvalerate affects the reaction [[SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium [SCN2A1 protein binds to SCN1B protein] which results in increased transport of Sodiumaffects binding|increases transport 18538810
D012964 Sodium [SCN2A protein binds to SCN1B protein] which affects the transport of Sodiumaffects binding|affects transport 9236205
D013779 Tetrodotoxin Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]affects binding|decreases activity 9236205
C028800 toxin II (Anemonia sulcata) toxin II (Anemonia sulcata) binds to and affects the activity of [SCN2A protein binds to SCN1B protein]affects activity|affects binding 9236205
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.9416487989
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8018218290 18057881 20041841
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.7012372130 20485159
MESH:D001281 Atrial Fibrillation Amiodarone 3.9019698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.9019483382
MESH:D001932 Brain Neoplasms Aspirin 4.4215481559
MESH:D001943 Breast Neoplasms Aspirin 3.2315161893
MESH:D053840 Brugada Syndrome marker/mechanism
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1018974383
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5312371664
MESH:D002779 Cholestasis Cyclosporine 2.9219486331
MESH:D003110 Colonic Neoplasms Aspirin 2.9812411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8711421492 18071297 12594235 14725611 16081117 11287661 12392966 12153990 19923254 19416960 16485898 12705907 14986274 17906064 11834606 19085960 19370779 11461765 16393943 15968718 14550746 10915739 16227642 19739265 11743745 16781746 19164858 16109766 15619225 16177239 10663392 18713872 17522070 12958197 10774834 2444490 17562736 19420014 12540782 11739529 11529661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 3.8718218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004417 Dyspnea cypermethrin 5.4216487989
MESH:D004487 Edema Aspirin 3.9017259670
MESH:D005234 Fatty Liver Amiodarone 7.8514986274
MESH:D005234 Fatty Liver Cyclosporine 7.8519224547
MESH:D005355 Fibrosis Cyclosporine 3.1512639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.7116983495
OMIM:604233 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1 marker/mechanism
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Aspirin 3.9612870263
MESH:D006261 Headache Aspirin 4.9915240983
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006505 Hepatitis cypermethrin 5.1716487989
MESH:D006529 Hepatomegaly Amiodarone 9.3615265979
MESH:D006529 Hepatomegaly fenvalerate 9.3615602828
MESH:D012001 Hyperacusis Aspirin 5.7915240983
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.888137927 9751232
MESH:D006965 Hyperplasia halofuginone 5.2611874485
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.8411484837
MESH:D006973 Hypertension Cyclosporine 2.1010903974
MESH:D007037 Hypothyroidism Amiodarone 4.5317991464 18020914
MESH:D007299 Insect Bites and Stings cypermethrin 6.0115189238
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.8018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7412371664
MESH:D008064 Lipidoses Amiodarone 3.5117567588 15342952
MESH:D008103 Liver Cirrhosis halofuginone 4.0317180598
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 2.9716489207 18458672 12175628 14739098 11172339
MESH:D008107 Liver Diseases Acetaminophen 4.4816610002 16611625 11587558 12969438 19014921 19460945 19784758 12587719
MESH:D008107 Liver Diseases cypermethrin 4.4815991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008133 Long QT Syndrome Amiodarone 3.5815350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5118516814
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D008881 Migraine Disorders Aspirin 4.0715240983
MESH:D009181 Mycoses Amiodarone 4.9312754197 17974566
MESH:D009203 Myocardial Infarction Aspirin 3.5512692751
MESH:D009325 Nausea Aspirin 5.2415240983
MESH:D009369 Neoplasms fenvalerate 3.962895627
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2918481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D010003 Osteoarthritis Aspirin 4.067009135
MESH:D010146 Pain Acetaminophen 6.9416870215
MESH:D010146 Pain Aspirin 6.946363464 6995502
MESH:D010243 Paralysis fenvalerate 6.028952708
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.5611156591
MESH:D020795 Photophobia Aspirin 5.7915240983
MESH:D011230 Precancerous Conditions Corn Oil 9.5014668109
MESH:D011230 Precancerous Conditions Cyclosporine 9.5012371664
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8512490602 12832656 11597910
MESH:D012220 Rhinitis Aspirin 4.3812372130
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1018724381
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.2812269725
MESH:D012871 Skin Diseases halofuginone 3.5111874485
MESH:D013276 Stomach Ulcer Amiodarone 3.3218087811
MESH:D020521 Stroke Aspirin 4.3816403987
MESH:D013610 Tachycardia Amiodarone 4.3011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2019225199
MESH:D013927 Thrombosis Aspirin 4.5217672075
MESH:D013959 Thyroid Diseases Amiodarone 4.7919731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.8718020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.2117467628 11989578
MESH:D014202 Tremor fenvalerate 5.598952708
MESH:D014570 Urologic Diseases cypermethrin 5.8916487989
MESH:D014581 Urticaria Acetaminophen 8.9210982225
MESH:D014581 Urticaria Aspirin 8.9220485159 10982225
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA302
    • No data
    Releated disease ID Related disease Name
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA444807Long QT Syndrome
    PA445019Myocardial Infarction
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    PA444065Epilepsy
    PA443421Arrhythmias, Cardiac
    PA443459Atrial Fibrillation
    Releated drug ID Related drug Name
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA448785carbamazepine
    PA450947phenytoin
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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