AutismKB 2.0

Annotation Detail for SCN2B


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Basic Information Top
Gene Symbol:SCN2B ( - )
Gene Full Name: sodium channel, voltage-gated, type II, beta
Band: 11q23.3
Quick LinksEntrez ID:6327; OMIM: 601327; Uniprot ID:SCN2B_HUMAN; ENSEMBL ID: ENSG00000149575; HGNC ID: 10589
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1818Systemic scleroderma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCN2B mRNAaffects expression 16483693
D002713 Chlorine Chlorine results in decreased expression of SCN2B mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of SCN2B mRNAaffects cotreatment|affects expression 18636392
D005472 Fluorouracil Fluorouracil affects the expression of SCN2B mRNAaffects expression 16584549
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of SCN2B mRNAaffects cotreatment|affects expression 18636392
D010269 Paraquat Paraquat results in increased expression of SCN2B mRNAincreases expression 17077588
C006253 pirinixic acid pirinixic acid results in increased expression of SCN2B mRNAincreases expression 12832660
C009250 sevoflurane sevoflurane affects the expression of SCN2B mRNAaffects expression 15967596
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SCN2B mRNAdecreases expression 18175754
D014501 Uranium Uranium affects the expression of SCN2B mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SCN2B mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury Chlorine 9.7720601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.7718653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4617638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.0011874814
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D000740 Anemia Fluorouracil 3.8715504547 16511603 17963324
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 2.6816373670 17854713
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4615136595 16110121 19217205 18608205 16595493 16557594 18357371
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8118315731 16777450 15516495 14754758 18417511 17626835 19059883
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1016332177 18930000 17045692 17971768 17088986 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0918695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5318986760 17066447 16757204 16280240
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617287894 16510598 17172411 17725105 17018589 16340194 18772588 15001691 17016597 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018448328 16303861 16391804 18509181 17255274 17695437 20501625 17454858 17094418 15148649 14970324 17594712 18802399 18383874 15289873 16331619 18949393 16524972 18288408 16282729 17401013 17016601
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3215131321
MESH:D004417 Dyspnea Chlorine 4.8920016425
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4816785472 15173087 17638652 16481741 16337965
MESH:D005234 Fatty Liver pirinixic acid 2.9320131406 19236843
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D005911 Gliosis Paraquat 5.4311124998
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015162350 18337622 15102660
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2119176532 19772884 18467677 16221962
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D007248 Infertility, Male Paraquat 3.364850670
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6714714311
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4516985049
MESH:D007859 Learning Disorders sevoflurane 4.9919212262
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms Fluorouracil 4.7217045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 4.7216377806 15890375 20007298
MESH:D008171 Lung Diseases Ozone 3.498266340 19066396
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Fluorouracil 2.7015246190
MESH:D008175 Lung Neoplasms Ozone 2.707614698 8597069
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D008569 Memory Disorders sevoflurane 4.9519212262
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7616757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms Fluorouracil 5.2418600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 5.2417405874
MESH:D009410 Nerve Degeneration Paraquat 3.8516893418
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7219003803 15113037 16929163 16500647
MESH:D010300 Parkinson Disease Paraquat 2.8711181820 11445065 16510128 12911755 15824117 15451049 16140633 11124998
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6516190885
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Ozone 11.8718381685 18929643 18007984
MESH:D011014 Pneumonia Paraquat 11.8712504350
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3419082440 18626508
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9716324872 17997886
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1615538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0911700416
MESH:D012135 Respiratory Sounds Paraquat 4.2711874814
MESH:D012162 Retinal Degeneration Paraquat 3.9916458197
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019015929 16424979 16951190 15786421 17498489 17172411 18567086 19084572 17522103 18396642
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA303
    • No data
    Releated disease ID Related disease Name
    PA443421Arrhythmias, Cardiac
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA445019Myocardial Infarction
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    PA444807Long QT Syndrome
    PA443459Atrial Fibrillation
    Releated drug ID Related drug Name
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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