AutismKB 2.0

Annotation Detail for SCN3A


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Basic Information Top
Gene Symbol:SCN3A ( KIAA1356,NAC3,Nav1.3 )
Gene Full Name: sodium channel, voltage-gated, type III, alpha subunit
Band: 2q24.3
Quick LinksEntrez ID:6328; OMIM: 182391; Uniprot ID:SCN3A_HUMAN; ENSEMBL ID: ENSG00000153253; HGNC ID: 10590
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2124Autistic disorder
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014949 acetylhydrazine acetylhydrazine results in decreased expression of SCN3A mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCN3A mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of SCN3A mRNAdecreases expression 19654921
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SCN3A mRNAincreases expression 20382639
C052570 cyfluthrin cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017160 cypermethrin cypermethrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SCN3A mRNAdecreases expression 15834898
C044267 fenpropathrin fenpropathrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
C017690 fenvalerate fenvalerate affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D005419 Flavonoids Flavonoids results in increased expression of SCN3A mRNAincreases expression 18035473
D012964 Sodium cyfluthrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium cypermethrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium fenpropathrin affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium fenvalerate affects the reaction [[SCN3A protein binds to SCN3B protein] which results in increased transport of Sodium]affects binding|affects reaction|increases transport 18538810
D012964 Sodium [SCN3A protein binds to SCN3B protein] which results in increased transport of Sodiumaffects binding|increases transport 18538810
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000382 Agricultural Workers' Diseases cypermethrin 5.1116487989
MESH:D020261 Arsenic Poisoning Arsenic 2.9016251483 18414634 12569548 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D050197 Atherosclerosis Arsenic 3.3312928151 19371607
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3016507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7217687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817110522 17681005 15861022 16919318 11677210 17333356 16105132
MESH:D004417 Dyspnea cypermethrin 5.6116487989
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D017029 Epilepsy, Complex Partial marker/mechanism 18242854
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.9515345470
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D006505 Hepatitis cypermethrin 5.3216487989
MESH:D006529 Hepatomegaly fenvalerate 5.1915602828
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006973 Hypertension Arsenic 2.9116076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Flavonoids 2.7117296493
MESH:D007299 Insect Bites and Stings cypermethrin 6.1915189238
MESH:D007642 Keratosis Arsenic 5.1816930632 12749816
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D008107 Liver Diseases Arsenic 4.9211134558
MESH:D008107 Liver Diseases cypermethrin 4.9215991261
MESH:D008113 Liver Neoplasms Arsenic 2.7216368122
MESH:D008175 Lung Neoplasms Arsenic 2.2017306315 17976673 19168569
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D009369 Neoplasms fenvalerate 4.022895627
MESH:D009436 Neural Tube Defects Arsenic 3.5416620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010243 Paralysis fenvalerate 6.208952708
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1815371236 6392382 16905509
MESH:D011471 Prostatic Neoplasms Arsenic 3.5916140617
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D012871 Skin Diseases Arsenic 2.7817453740 16353154 18709164 16702368 17050553 16759981 17938729 6392382 15952646 19834688 17548696
MESH:D012878 Skin Neoplasms Arsenic 3.0717050553 19538983 17976673 15504454 16251483 17029826
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D014202 Tremor fenvalerate 5.788952708
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8615987713 19322015 18640142 17306315 17976673 11144890 19429237
MESH:D014570 Urologic Diseases cypermethrin 6.0816487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35005
    • No data
    Releated disease ID Related disease Name
    PA444065Epilepsy
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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