AutismKB 2.0

Annotation Detail for SCN4B


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Basic Information Top
Gene Symbol:SCN4B ( - )
Gene Full Name: sodium channel, voltage-gated, type IV, beta
Band: 11q23.3
Quick LinksEntrez ID:6330; OMIM: 608256; Uniprot ID:SCN4B_HUMAN; ENSEMBL ID: ENSG00000177098; HGNC ID: 10592
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2092Long QT syndrome
No data
No data
Desease Name
Long QT syndrome-10
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SCN4B mRNAaffects cotreatment|increases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SCN4B mRNAincreases expression 20382639
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SCN4B mRNAaffects cotreatment|increases expression 18164116
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of SCN4B mRNAdecreases expression 16221955
C006253 pirinixic acid pirinixic acid results in increased expression of SCN4B mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SCN4B mRNAincreases expression 20159946
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.4419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.446695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.1716434500 18056438 19052882 17162532 19061943 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.1716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.1716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8718785209 18494052 18393292 19107877 19701751 18978308 20214788 20101231 21159647 19418558 16935385 16681979 11831363 19822196 16288022 16878318 17173139 20512989 3581430 20007298 10672840 20524982 17978847 20727157 17138121 18971187 20935162 19383236 19519916 16698587 16807293 17162532 19335982 18665156 20084675 20432363 19394651 16328049 19539802 18056438 17055752 18788625 3084413 10737359 16569478 18691550 16779866 16502159 18506893 16540662 19171122 16830150 19919837 17761372 19052882 19208518 20514400 18210153 17428255
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3820889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.3821159647 2727394 7505956 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.2919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.2916835633
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema perfluorooctanoic acid 13.4212083418 17259670
MESH:D004487 Edema pirinixic acid 13.4212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.4211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7821071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.7819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 17.043609246
MESH:D006529 Hepatomegaly pirinixic acid 17.0416221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.0415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.1012083418
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 9.2318785209
MESH:D007249 Inflammation perfluorooctanoic acid 9.2312083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.2312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.698812269
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9820032147 18407596 18665156 18522880 19638242
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2112878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 15.3421295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.3419427195 18648771 2422723 19499222 20118626 20492335 19090486 18644402 20583210 20405173 19551842 12771043 18978307 20137499 20501860 18754104 20434301 19254457 19850985 19833225 19255062 10737359 16942905 19690152 15885732 19812893 19294768 19426721 19642983 19073162 2862719 21278145 19996281 21047994 21167192 19256749 21071580 12112319 20101389 19638242 18977376 15175105 20452335 9163691
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 15.3414757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 15.3420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.3416984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.9418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.9416842330 18544905 2563599 3124819 19126423 18775883 18164116 18079962 19539802 17942915 18282651 18093689 19004024 18253720 17854601 19009564 9362446 19519916 17174075 16267830 21159647 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.9412151625
MESH:D008133 Long QT Syndrome marker/mechanism
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3320512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.673581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.379802331
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 11.2617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.2611896295 11222880 11118676 11399792
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35007
    • No data
    Releated disease ID Related disease Name
    PA447228congenital long QT syndrome
    PA446379Death, Sudden, Cardiac
    PA446294Torsades de Pointes
    PA444807Long QT Syndrome
    PA443459Atrial Fibrillation
    Releated drug ID Related drug Name
    PA448383amiodarone
    PA452233antipsychotics
    PA448486arsenic trioxide
    PA448498astemizole
    PA164754755bepridil
    PA448948chloroquine
    PA448964chlorpromazine
    PA449011cisapride
    PA449028clarithromycin
    PA449373disopyramide
    PA449389dofetilide
    PA134711056domperidone
    PA449422droperidol
    PA449493erythromycin
    PA449839halofantrine
    PA449841haloperidol
    PA449958ibutilide
    PA450215levomethadyl acetate
    PA450386mesoridazine
    PA450401methadone
    PA450850pentamidine
    PA450965pimozide
    PA451108procainamide
    PA451209quinidine
    PA451457sotalol
    PA451472sparfloxacin
    PA451619terfenadine
    PA451666thioridazine
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00909 antagonist Zonisamide Antioxidants;Anticonvulsants
    No data
    No data
    No data

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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