AutismKB 2.0

Annotation Detail for SCN7A


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Basic Information Top
Gene Symbol:SCN7A ( SCN6A )
Gene Full Name: sodium channel, voltage-gated, type VII, alpha
Band: 2q24.3
Quick LinksEntrez ID:6332; OMIM: 182392; Uniprot ID:SCN7A_HUMAN; ENSEMBL ID: ENSG00000136546; HGNC ID: 10594
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
Amyotrophic Lateral Sclerosis
NEUROLOGICAL
Desease Name
Amyotrophic lateral sclerosis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic results in decreased expression of SCN7A mRNAdecreases expression 19654921
C015001 arsenite arsenite results in decreased expression of SCN7A mRNAdecreases expression 18191166
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SCN7A mRNAincreases expression 13678700
D002251 Carbon Tetrachloride Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of SCN7A mRNA]decreases reaction|increases expression 13678700
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SCN7A mRNAdecreases expression 15834898
17351261
D005419 Flavonoids Flavonoids results in increased expression of SCN7A mRNAincreases expression 18035473
D019833 Genistein Genistein results in increased expression of SCN7A mRNAincreases expression 17341692
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of SCN7A mRNAdecreases expression 12057914
D014635 Valproic Acid Valproic Acid results in increased expression of SCN7A mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of SCN7A mRNAaffects expression 19015723
C108830 Y 27632 Y 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of SCN7A mRNA]decreases reaction|increases expression 13678700
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2111850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4814692618
MESH:D000230 Adenocarcinoma Genistein 4.4811473722
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4817306315
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9112569548 18414634 16835338 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D050197 Atherosclerosis Arsenic 3.3419371607 12928151
MESH:D001321 Autistic Disorder marker/mechanism 18621663
MESH:D001321 Autistic Disorder Valproic Acid 1.9920603192 18316065 18985861 18177632 19460635 18940202 18558336 17688650 18396377 17157402 19232924 16609825 15238991 18775368 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001943 Breast Neoplasms Genistein 2.5116873071 17200150 16541309
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.993786805 15673190 16192424 16227642 10355542 15700767 16124888 15721981 16097048 18705752 16011737 16050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6815504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8216507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8218788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8216924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7317687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2418640142
MESH:D002318 Cardiovascular Diseases Arsenic 7.8915738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 7.8916332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.4618022660 16973168
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017681005 11677210 16919318 15861022 16105132 17333356 17110522
MESH:D003110 Colonic Neoplasms arsenite 4.0715037631
MESH:D003110 Colonic Neoplasms Genistein 4.0717182828
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5216647724
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.103732212 3786805 7179309 4309450 10915739 7440962 21278145 16227642 6884620 15968718 11566570 7120509 15998439 17522070 15027814 16177239 6623471 19336974 2869522 19085960 10092053 9327722
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.101733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4711473722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6317637181 15821434 15328337
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.373659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.747562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005234 Fatty Liver arsenite 20.2918296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2916239168 16045604 17595544 61145 12631006 12795759 15959796 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2915345470
MESH:D005234 Fatty Liver Valproic Acid 20.2914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005334 Fever Lipopolysaccharides 4.1711852909 9205823
MESH:D005355 Fibrosis arsenite 9.7418296743
MESH:D005355 Fibrosis Carbon Tetrachloride 9.7418705752
MESH:D005534 Foot Diseases Arsenic 5.826392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5516366002
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6217050553
MESH:D006973 Hypertension Arsenic 2.9216076760 9931084 11953799
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D006987 Hypesthesia Arsenic 5.8216093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Flavonoids 5.6417296493
MESH:D007249 Inflammation Lipopolysaccharides 5.649205823 12878042 17963957 17237260 17255318
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8117255318
MESH:D007642 Keratosis Arsenic 5.2312749816 16930632
MESH:D007938 Leukemia Genistein 3.1017468513 18980019
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6617339181
MESH:D007970 Leukopenia Lipopolysaccharides 4.9315821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis arsenite 7.1218296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1217174718 21278145 16221502 11903743 11408273 16239168 17334410 17157831 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.2617565644 17900296 12741479 12632514 18395914 18054572 17721639 15818738 18418968 18420326 16116963 17922224 15893842 17805973 18279442 17976157 17525996 16097048 15876570 12389079 12546737 17481882 15996030 17698563 15057751 15925388 20821823 17823541 12445421 14512876 18187930 17869086 12667390 15931870 18156304 18006644 18412020 14620537 12958196 17944888 14724832 18317297 11481614 16011737 17640975 18472094 16027843 12649538 12632512 18472332 18339082 17708605 16192424 18166357 18205269 16638106 17557913 18395095 15362042 18277467 12898905 15370692 17766677 16015684 17631135 12666154 10355542 18210741 15123356 16136751 15650968 16248980 17714472 12445418 18251166 18263696 13678700 12609069 18376398 16033810 12586293 14748882 18705752 18481824 18429990 15673190 15730626 15959796 15338365 15052691 14716496 17761835 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.2617823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Y 27632 5.2613678700
MESH:D008107 Liver Diseases Arsenic 4.3611134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3616246199 15830285 16964402 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8514706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 4.9416368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9419294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7112014681 15583823
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D055370 Lung Injury Lipopolysaccharides 4.2221114838
MESH:D008175 Lung Neoplasms Arsenic 2.8717306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenite 2.8716809336
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0412929590 14578162
MESH:D008881 Migraine Disorders Valproic Acid 3.3118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction Genistein 2.9217141266
MESH:D017202 Myocardial Ischemia Arsenic 4.1215371236
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7917141266
MESH:D009389 Neovascularization, Pathologic arsenite 4.6515738583
MESH:D009421 Nervous System Malformations Genistein 4.2316427766
MESH:D009436 Neural Tube Defects Arsenic 7.8116620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.818888407 16359493
MESH:D020078 Neurogenic Inflammation Arsenic 4.5617056641
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010051 Ovarian Neoplasms Arsenic 5.2517306315
MESH:D010051 Ovarian Neoplasms Genistein 5.2519005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.2315371236 6392382 16905509
MESH:D011014 Pneumonia Lipopolysaccharides 4.7911605937 12224865
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.5318220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.4416140617
MESH:D011471 Prostatic Neoplasms Genistein 3.4415256057 15378649 16925846
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011507 Proteinuria Arsenic 4.1921343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8410835634
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8514763951 16876388 11044598 11738929 1511512 17978042 3137016 15475178
MESH:D012871 Skin Diseases Arsenic 2.7817050553 17453740 17938729 16353154 17548696 16759981 19834688 18709164 15952646 6392382 16702368
MESH:D012878 Skin Neoplasms Arsenic 3.0817029826 19538983 17976673 15504454 17050553 16251483
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3315821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8718640142 17306315 19429237 19322015 15987713 17976673 11144890
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014652 Vascular Diseases Arsenic 4.9717056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35008
    • No data
    Releated disease ID Related disease Name
    PA447198Autistic Disorder
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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