AutismKB 2.0

Annotation Detail for SCN10A


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Basic Information Top
Gene Symbol:SCN10A ( Nav1.8,PN3,SNS,hPN3 )
Gene Full Name: sodium channel, voltage-gated, type X, alpha subunit
Band: 3p22.2
Quick LinksEntrez ID:6336; OMIM: 604427; Uniprot ID:SCNAA_HUMAN; ENSEMBL ID: ENSG00000185313; HGNC ID: 10582
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
Electrocardiographic traits
Desease Name
Electrocardiographic traits
PR interval
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C489827 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D000487 Allethrin Allethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C099952 bifenthrin bifenthrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C408069 BIII 890 CL BIII 890 CL inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C408069 BIII 890 CL BIII 890 CL inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
D002211 Capsaicin SCN10A protein affects the reaction [Capsaicin results in increased secretion of TAC1 protein alternative form]affects reaction|increases secretion 18845912
C017498 cismethrin cismethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C052570 cyfluthrin cyfluthrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C037304 cyhalothrin cyhalothrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C017160 cypermethrin cypermethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C017180 decamethrin BIII 890 CL inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C017180 decamethrin decamethrin results in increased activity of SCN10A proteinincreases activity 16325806
C017180 decamethrin Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C017180 decamethrin NW 1029 inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C017180 decamethrin Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C017180 decamethrin BIII 890 CL inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C017180 decamethrin decamethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C017180 decamethrin NW 1029 inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C017180 decamethrin Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
D004041 Dietary Fats Dietary Fats results in decreased expression of SCN10A mRNAdecreases expression 18042831
C044267 fenpropathrin fenpropathrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C017690 fenvalerate fenvalerate affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
C011890 kojic acid kojic acid results in decreased expression of SCN10A mRNAdecreases expression 16595896
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of SCN10A mRNAdecreases expression 16525678
D008801 Mexiletine Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C475054 NW 1029 NW 1029 inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C475054 NW 1029 NW 1029 inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
C041786 palm oil palm oil results in decreased expression of SCN10A mRNAdecreases expression 18042831
D026023 Permethrin Permethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D011189 Potassium Chloride SCN10A protein affects the reaction [Potassium Chloride results in increased secretion of TAC1 protein alternative form]affects reaction|increases secretion 18845912
D012964 Sodium 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium Allethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium bifenthrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium cismethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium cyfluthrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium cyhalothrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium cypermethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium decamethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium fenpropathrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium fenvalerate affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium Permethrin affects the reaction [SCN10A protein results in increased transport of Sodium]affects reaction|increases transport 16051293
D012964 Sodium SCN10A protein results in increased transport of Sodiumincreases transport 16051293
D013748 Tetracaine Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
D013748 Tetracaine Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]decreases reaction|increases activity 16325806
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 4.4018926900
MESH:D058186 Acute Kidney Injury Capsaicin 4.4218460982
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.0915113128 15688392
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.7916487989
MESH:D000505 Alopecia Capsaicin 4.6217569567
MESH:D001161 Arteriosclerosis Dietary Fats 3.7615238619
MESH:D001281 Atrial Fibrillation marker/mechanism 20062060
MESH:D001919 Bradycardia Capsaicin 4.9318207255
MESH:D002545 Brain Ischemia Capsaicin 4.8419211983
MESH:D001943 Breast Neoplasms Dietary Fats 2.5520435547
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.5511306469 16253758 14633655
MESH:D002386 Cataract Methylnitrosourea 3.9112484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 3.717505956 2727394
MESH:D003371 Cough Capsaicin 5.0510350223
MESH:D019465 Craniofacial Abnormalities decamethrin 3.6019861644
MESH:D019465 Craniofacial Abnormalities Permethrin 3.6019861644
MESH:D003877 Dermatitis, Contact Permethrin 4.8714617103
MESH:D004381 Duodenal Ulcer Capsaicin 4.5610671773 11535926
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004417 Dyspnea cypermethrin 5.2616487989
MESH:D004935 Esophageal Diseases Capsaicin 5.5719566590
MESH:D005234 Fatty Liver Dietary Fats 3.1219004024 17967931 18296743 19551842
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.1011555667
MESH:D005355 Fibrosis Dietary Fats 3.4018296743
MESH:D005909 Glioblastoma Capsaicin 4.0318405923
MESH:D005910 Glioma Methylnitrosourea 3.519825942
MESH:D006327 Heart Block marker/mechanism 20062061
MESH:D006356 Heartburn Capsaicin 5.5719566590
MESH:D006505 Hepatitis cypermethrin 5.0416487989
MESH:D006529 Hepatomegaly fenvalerate 4.8815602828
MESH:D006930 Hyperalgesia Capsaicin 4.2217434803 17043245
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D007248 Infertility, Male Methylnitrosourea 3.717193160
MESH:D007249 Inflammation Capsaicin 5.3116956363
MESH:D007249 Inflammation Dietary Fats 5.3120412841
MESH:D007299 Insect Bites and Stings cyhalothrin 29.9915189238
MESH:D007299 Insect Bites and Stings cypermethrin 29.9915189238
MESH:D007299 Insect Bites and Stings decamethrin 29.9915189238
MESH:D007299 Insect Bites and Stings Permethrin 29.9912749493 15189238 12971516
MESH:D007333 Insulin Resistance Dietary Fats 3.0211836018 18457598
MESH:D007938 Leukemia Permethrin 4.0612937054
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.1115526292
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8118296743
MESH:D008107 Liver Diseases Capsaicin 4.9616956363
MESH:D008107 Liver Diseases cypermethrin 4.9615991261
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.2518544905
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.3316080182
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.6918062963
MESH:D008223 Lymphoma Methylnitrosourea 3.9216257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.6514633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.5011807958 14999141 15313902 15688392 16827153 16944150 16051031 16619500 17131329 10767621 15113128 14633655 10838139 17020996 11751437 19196723 12931682
MESH:D009101 Multiple Myeloma Capsaicin 4.0617505005
MESH:D009369 Neoplasms fenvalerate 5.772895627
MESH:D009369 Neoplasms Methylnitrosourea 5.7715533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.3412696579
MESH:D009442 Neurilemmoma Methylnitrosourea 5.3511555667
MESH:D020078 Neurogenic Inflammation Capsaicin 4.9617961222
MESH:D009765 Obesity Capsaicin 4.9019056576
MESH:D009765 Obesity Dietary Fats 4.9016723640 20132043 18457598 19632207 20518802 11836018 21332399 18674790 17217161
MESH:D010146 Pain Capsaicin 7.9819081190 17084039 17434803 16996476 18987195 17043245
MESH:D010146 Pain Mexiletine 7.9815215642
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.3116965848
MESH:D010243 Paralysis fenvalerate 5.878952708
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 4.1412376480 15682402
MESH:D015427 Reperfusion Injury Capsaicin 3.9018460982 19211983
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.3118172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.3511555667
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6915930296 18593901 16257854
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.5917997062
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.1011418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 3.823078959 7505956
MESH:D014202 Tremor fenvalerate 5.448952708
MESH:D014570 Urologic Diseases cypermethrin 5.7416487989
MESH:D014693 Ventricular Fibrillation marker/mechanism 20062061
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00281 antagonist Xylonor Spray Antiarrhythmic Agents;Anesthetics;Anesthetics, Local;Anti-Arrhythmia Agents
DB00296 antagonist Ropivacaine Anesthetics;Local Anesthetics;Anesthetics, Local
DB00297 antagonist Sensorcaine Forte Anesthetics, Local
DB00473 antagonist Hexylcaine Anesthetics;Local Anesthetics
DB00527 antagonist Sandoz Proctomyxin Hc Anesthetics, Local
DB00645 blocker Tanac Medicated Gel Anesthetics, Local;Anesthetics, Mucosal-Local
DB00721 antagonist Procaine Anesthetics;Local Anesthetics;Anesthetics, Local
DB00807 antagonist Proparacaine Local Anesthetics;Anesthetics, Local
DB00892 antagonist Fluress Anesthetics, Local
DB00907 blocker Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
DB00961 blocker Scandonest 2% Special Inj Anesthetics, Local
DB01002 antagonist Levobupivacaine Anesthetics;Anesthetics, Local
DB01086 antagonist Zap Topical Anesthetic Spray Antipruritics;Anesthetics;Local Anesthetics;Anesthetics, Local
DB01161 antagonist Chloroprocaine Anesthetics, Local
DB01173 antagonist Orphenadrine Skeletal Muscle Relaxants;Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Muscle Relaxants, Central;Parasympatholytics
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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