AutismKB 2.0

Annotation Detail for SCNN1B


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Basic Information Top
Gene Symbol:SCNN1B ( BESC1,ENaCb,ENaCbeta,SCNEB )
Gene Full Name: sodium channel, nonvoltage-gated 1, beta
Band: 16p12.2-p12.1
Quick LinksEntrez ID:6338; OMIM: 600760; Uniprot ID:SCNNB_HUMAN; ENSEMBL ID: ENSG00000168447; HGNC ID: 10600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04960Aldosterone-regulated sodium reabsorption
hsa04742Taste transduction
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00243Hyperkalemic distal renal tubular acidosis (RTA type 4)
Urinary system diseases
Kidney diseases
Desease IDDesease Name
1712Yersinia infection
1826Cystic fibrosis
2032Kidney disease
2091Hypertension
2073Bronchiectasis
2094Ulcerative colitis
Desease Name
cystic fibrosis
CARDIOVASCULAR
hypertension
preeclampsia
REPRODUCTION
No data
Desease Name
Bronchiectasis with or without elevated sweat chloride 1
Pseudohypoaldosteronism, type I
Liddle syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015929 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|affects cotreatment|increases activity 15161604
C055656 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]affects binding|increases activity 19359370
C090860 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate results in increased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]affects binding|increases activity 19359370
D000450 Aldosterone Aldosterone results in increased expression of SCNN1B mRNAincreases expression 18665318
D000450 Aldosterone Aldosterone results in increased expression of SCNN1B proteinincreases expression 18665318
D000584 Amiloride Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]affects binding|decreases reaction|increases transport 18665318
D000584 Amiloride Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]affects binding|decreases activity 19359370
D000584 Amiloride Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 18398334
18665318
D000584 Amiloride Amiloride affects the activity of SCNN1B proteinaffects activity 8617496
C013407 benzamil benzamil results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 18024548
D020126 Brefeldin A Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]]decreases expression|decreases reaction 12608646
D001965 Bromides Bromides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16027156
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SCNN1B mRNAincreases expression 16644059
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SCNN1B proteinincreases expression 16192424
D002712 Chlorides Chlorides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 15161604
16027156
D003894 Deamino Arginine Vasopressin Deamino Arginine Vasopressin results in increased expression of SCNN1B mRNAincreases expression 11711512
D003907 Dexamethasone Dexamethasone results in increased expression of SCNN1B mRNAincreases expression 19344079
D003907 Dexamethasone Dexamethasone results in increased expression of SCNN1B mRNAincreases expression 12682491
D004967 Estrogens Estrogens affects the activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects activity|affects binding 17939260
D004967 Estrogens Estrogens affects the expression of SCNN1B mRNAaffects expression 17939260
D004967 Estrogens Estrogens affects the expression of SCNN1B proteinaffects expression 17939260
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SCNN1B mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of SCNN1B mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil affects the expression of SCNN1B mRNAaffects expression 16584549
D005839 Gentamicins Gentamicins results in increased expression of SCNN1B proteinincreases expression 16850027
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SCNN1B mRNAaffects cotreatment|increases expression 17183730
D006854 Hydrocortisone Hydrocortisone results in increased expression of SCNN1B mRNAincreases expression 17715387
D007454 Iodides Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16027156
D015056 1-Methyl-3-isobutylxanthine [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|affects cotreatment|increases activity 15161604
D008094 Lithium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Lithiumaffects binding|increases transport 18665318
D009566 Nitrates Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16027156
D010100 Oxygen Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]]decreases expression|decreases reaction 12608646
D010100 Oxygen Oxygen deficiency results in decreased expression of SCNN1B proteindecreases expression 12372821
D010100 Oxygen Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]decreases expression|decreases reaction 12372821
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCNN1B mRNAaffects binding|decreases expression|increases activity 19710929
D011188 Potassium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Potassiumaffects binding|increases transport 18665318
D011374 Progesterone Progesterone affects the activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects activity|affects binding 17939260
D011374 Progesterone Progesterone affects the expression of SCNN1B mRNAaffects expression 17939260
D011374 Progesterone Progesterone affects the expression of SCNN1B proteinaffects expression 17939260
D011374 Progesterone Progesterone results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16172119
D011692 Puromycin Aminonucleoside Puromycin Aminonucleoside results in decreased expression of SCNN1B mRNAdecreases expression 16020936
D012964 Sodium Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]affects binding|decreases reaction|increases transport 18665318
D012964 Sodium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein binds to SCNN1D protein] which results in increased transport of Sodiumaffects binding|increases transport 19359370
D012964 Sodium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which affects the transport of Sodiumaffects binding|affects transport 18398334
D012964 Sodium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodiumaffects binding|increases transport 18665318
D012964 Sodium [SCNN1A protein binds to SCNN1B protein mutant form binds to SCNN1G protein] which results in increased transport of Sodiumaffects binding|increases transport 18398334
D012964 Sodium SCNN1B protein affects the transport of Sodiumaffects transport 8617496
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary affects the localization of SCNN1B proteinaffects localization 18024548
D013726 Terbutaline Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]]decreases expression|decreases reaction 12608646
D013726 Terbutaline Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]decreases expression|decreases reaction 12372821
D013890 Thiourea Thiourea results in decreased expression of SCNN1B mRNAdecreases expression 15248066
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SCNN1B mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 7.9914610225
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.998875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D058186 Acute Kidney Injury Gentamicins 4.2611274264
MESH:D055371 Acute Lung Injury Oxygen 8.2316759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0414692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.0417638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.1616434500
MESH:D000544 Alzheimer Disease Lithium 3.3919621015
MESH:D000550 Amblyopia Valproic Acid 4.9017688650
MESH:D000686 Amyloidosis Terbutaline 5.327986221
MESH:D000740 Anemia Fluorouracil 3.4316511603 15504547 17963324
MESH:D000860 Anoxia Oxygen 4.7320872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.3217497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.7117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D050197 Atherosclerosis Oxygen 3.6116391483
MESH:D001321 Autistic Disorder Terbutaline 2.5917400887 16417856
MESH:D001321 Autistic Disorder Valproic Acid 2.5917157402 15238991 17507914 18558336 17688650 19460635 20603192 19232924 18316065 18775368 16609825 18177632 18396377 18940202 18985861
MESH:D001714 Bipolar Disorder Lithium 7.0620046352 19153942 20338123 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 7.0617594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8619483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.198888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 3.9415665606 15380490 15845082
MESH:D001943 Breast Neoplasms Fluorouracil 2.1016110121 16557594 15136595 19217205 18608205 16595493 18357371
MESH:D001943 Breast Neoplasms Oxygen 2.1017263869
MESH:D001943 Breast Neoplasms Progesterone 2.1015562024 16175315 17614352
OMIM:211400 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 1 marker/mechanism
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.539428835 11713377
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4615673190 16011737 15721981 16097048 3786805 16124888 10355542 16192424 16227642 15700767 16050911 18705752
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3416051944
MESH:D002277 Carcinoma Fluorouracil 3.3117121937
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.4918788625
MESH:D006528 Carcinoma, Hepatocellular Estrogens 4.4915341023
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.4917971768 17045692 16799960 17088986 18930000 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8618695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.4018986760 16280240 17066447 16757204
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.8014644129
MESH:D002318 Cardiovascular Diseases Aldosterone 4.5011230374
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9517681005 16105132 17110522 15861022 16919318 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 6.9519176532
MESH:D002972 Cleft Palate Hydrocortisone 4.0115826874
MESH:D003092 Colitis Amiloride 4.7912065299
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7115824018
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7117172411 16510598 17018589 15001691 17016597 17725105 17169374 18772588 17287894 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9917255274 16391804 14970324 18802399 17016601 15148649 16331619 17695437 18288408 20501625 16303861 16524972 17401013 16282729 18448328 18949393 17454858 15289873 17594712 18509181 17094418 18383874
MESH:D003371 Cough Terbutaline 5.2319679606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.8817728286
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 3.8817728286
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.888888407 16575769 17688650
MESH:D016638 Critical Illness Estrogens 5.6216670151
MESH:D003550 Cystic Fibrosis marker/mechanism 16463024 16207733
MESH:D007644 Darier Disease Fluorouracil 12.1216733453
MESH:D007644 Darier Disease Lithium 12.1220338123
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.1012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.4319244398
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D003967 Diarrhea Dexamethasone 7.597237001
MESH:D003967 Diarrhea Hydrocortisone 7.597237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.637179309 10915739 7120509 21278145 6623471 2869522 10092053 19085960 11566570 16227642 4309450 16177239 15027814 7440962 9327722 3786805 6884620 15968718 17522070 19336974 3732212 15998439
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.631733752 19641884
MESH:D004362 Drug Toxicity Gentamicins 4.2011033412 15033597
MESH:D004417 Dyspnea Oxygen 4.5020016425
MESH:D004421 Dystonia Valproic Acid 3.751851702
MESH:D004485 Eczema Dexamethasone 4.1512438553
MESH:D004487 Edema Dexamethasone 5.9719703484
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.0112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.0117692515
MESH:D004715 Endometriosis Progesterone 3.4916134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.843659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.593922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.326254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.743659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3715173087 17638652 16785472 16481741 16337965
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.3715959796 12795759 61145 12631006 17595544 16045604 19224547 16239168
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.3715345470
MESH:D005234 Fatty Liver pirinixic acid 16.3720131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 16.3719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.5616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8218558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3018705752
MESH:D005355 Fibrosis Terbutaline 8.3015467267
MESH:D005739 Gas Poisoning Oxygen 4.8920016425
MESH:D005910 Glioma Fluorouracil 2.7416145905
MESH:D006130 Growth Disorders Amiloride 4.5519703807
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1718337622 15162350 15102660
MESH:D034381 Hearing Loss Gentamicins 4.6115968427 18024279 19130971 17868369
MESH:D006330 Heart Defects, Congenital Lithium 4.0419638421
MESH:D006333 Heart Failure pirinixic acid 2.3420558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 2.6819176532 16221962 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.957520565
MESH:D006849 Hydrocephalus Valproic Acid 4.5417688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2116899240
MESH:D053565 Hypercalciuria Gentamicins 5.3817652376
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006973 Hypertension marker/mechanism 15174897 15198480 19344079
MESH:D006973 Hypertension Amiloride 8.4418524855 15174897 19344079
MESH:D006973 Hypertension Dexamethasone 8.4417042910
MESH:D006973 Hypertension Sodium Chloride, Dietary 8.4418524855
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7715338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.3116612254
MESH:D006985 Hyperventilation Terbutaline 5.7510895896
MESH:D007008 Hypokalemia Terbutaline 5.7717292646
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 12.0319822448
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 12.0319822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1118306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2717937319
MESH:D007249 Inflammation Amiloride 10.6617237260
MESH:D007249 Inflammation Dexamethasone 10.6611099482 8960868
MESH:D007249 Inflammation Flavonoids 10.6617296493
MESH:D007249 Inflammation Progesterone 10.6615869954
MESH:D007333 Insulin Resistance pirinixic acid 2.4216306350
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1118306037
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.4018842672
MESH:D007674 Kidney Diseases Gentamicins 3.6419349640 17934191 18289764
MESH:D007680 Kidney Neoplasms Fluorouracil 3.0516985049
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.0511231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.2010219319
MESH:D053609 Lethargy Terbutaline 5.9810895896
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1016294345 17596541
MESH:D056929 Liddle Syndrome marker/mechanism 18398334 19344079
MESH:D056929 Liddle Syndrome Amiloride 5.6519344079
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6316943688 16239168 11903743 16221502 11408273 21278145 17157831 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7218166357 12958196 12741479 18277467 14512876 15338365 16015684 18472094 16097048 16192424 15876570 18395914 18054572 17766677 17698563 18412020 18395095 15673190 12609069 12632514 20821823 16638106 17481882 17708605 18263696 17640975 16136751 17631135 18420326 18187930 18418968 17557913 12667390 18251166 17869086 12649538 15893842 15818738 15370692 13678700 16011737 18376398 17565644 12898905 18429990 17761835 12586293 17805973 18006644 18210741 17525996 12632512 17976157 15931870 15650968 17922224 18705752 12445421 15959796 16248980 18156304 12546737 18317297 17714472 18279442 15730626 14716496 18481824 12389079 16027843 18339082 12445418 16116963 17823541 14716833 18472332 10355542 11481614 15057751 14748882 14724832 15925388 18205269 15052691 17944888 15123356 16033810 17721639 15996030 12666154 14620537 15362042 17900296
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.7216718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7215474484
MESH:D008106 Liver Cirrhosis, Experimental Puromycin Aminonucleoside 4.7216570917
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0016246199 15830285 16964402 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4116899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.6919294768
MESH:D008113 Liver Neoplasms Fluorouracil 6.6915113037 18383874 16603448 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 6.6915890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.4212014681 15583823
MESH:D008171 Lung Diseases marker/mechanism 16207733
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9317228818
MESH:D055370 Lung Injury Oxygen 4.1918339021
MESH:D008175 Lung Neoplasms Dexamethasone 2.6211195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 2.6215246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4715086387
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.6617203775 11408345
MESH:D008881 Migraine Disorders Valproic Acid 2.9618765137 18803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3916757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 3.2815744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.9418694830
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.748888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.949809623
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.9417596541
MESH:D009203 Myocardial Infarction Lithium 5.6016288908
MESH:D009203 Myocardial Infarction pirinixic acid 5.6019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7016411023
MESH:D009361 Neoplasm Invasiveness Amiloride 4.9914644129
MESH:D009369 Neoplasms Fluorouracil 4.4418600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 4.4417405874
MESH:D009401 Nephrosis Puromycin Aminonucleoside 6.1815829708 11170791
MESH:D009404 Nephrotic Syndrome Puromycin Aminonucleoside 5.4616020936
MESH:D009436 Neural Tube Defects Valproic Acid 2.928888407 16359493
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2216436463
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.7814998686
MESH:D010051 Ovarian Neoplasms Progesterone 2.4217393432 16525653
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.5519003803 16929163 15113037 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3621297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.5120603192
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5118626508 19082440
MESH:D011507 Proteinuria Gentamicins 4.4215033597
MESH:D011537 Pruritus Ethinyl Estradiol 2.9916919318 15861022
MESH:D011546 Pseudohypoaldosteronism marker/mechanism
MESH:D019310 Pseudolymphoma Valproic Acid 4.2112752131 11422049
MESH:D011654 Pulmonary Edema Terbutaline 10.6610903255
MESH:D011654 Pulmonary Edema Thiourea 10.6610849556
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7416160472 18722050 15538739 18286688
MESH:D051437 Renal Insufficiency Gentamicins 4.6817132701 15728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 13.7411700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 13.7417627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 13.742878809
MESH:D012173 Retinitis Gentamicins 5.9418644591
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures Lithium 5.7519660546
MESH:D012640 Seizures Valproic Acid 5.7511738929 14763951 3137016 16876388 17978042 15475178 1511512 11044598
MESH:D012772 Shock, Septic Terbutaline 5.173431524
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9515862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5319490988
MESH:D013226 Status Epilepticus Lithium 11.5619570321 19430551 19951488
MESH:D013226 Status Epilepticus Valproic Acid 11.5612833885
MESH:D013272 Stomach Diseases Dexamethasone 4.0015472012
MESH:D013274 Stomach Neoplasms Fluorouracil 1.9916424979 17498489 18396642 19084572 18567086 19015929 16951190 17522103 17172411 15786421
MESH:D013276 Stomach Ulcer Dexamethasone 3.2115138204
MESH:D013398 Sudden Infant Death Oxygen 5.2212563064
MESH:D013610 Tachycardia Terbutaline 5.1910895896
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7116280240
MESH:D014178 Translocation, Genetic Valproic Acid 4.9017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.193119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.328888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.6016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D014605 Uveitis Dexamethasone 4.491336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D015837 Vestibular Diseases Gentamicins 5.2118776599
MESH:D014947 Wounds and Injuries Estrogens 4.4811172683
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04742 Taste transduction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA306
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA449782glibenclamide
    PA449992insulin-glargine
    PA448682bumetanide
    PA451733torasemide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00384 antagonist Riva-Zide 50/25mg Tablets Diuretics;Potassium-sparing Diuretics
    DB00594 blocker Riva-Amilzide 5/50 mg Sodium channel blockers;Diuretics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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