AutismKB 2.0

Annotation Detail for SCNN1G


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Basic Information Top
Gene Symbol:SCNN1G ( BESC3,ENaCg,ENaCgamma,PHA1,SCNEG )
Gene Full Name: sodium channel, nonvoltage-gated 1, gamma
Band: 16p12.2
Quick LinksEntrez ID:6340; OMIM: 600761; Uniprot ID:SCNNG_HUMAN; ENSEMBL ID: ENSG00000166828; HGNC ID: 10602
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04960Aldosterone-regulated sodium reabsorption
hsa04742Taste transduction
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00243Hyperkalemic distal renal tubular acidosis (RTA type 4)
Urinary system diseases
Kidney diseases
Desease IDDesease Name
1826Cystic fibrosis
2091Hypertension
2073Bronchiectasis
2094Ulcerative colitis
Desease Name
CARDIOVASCULAR
hypertension
No data
Desease Name
Pseudohypoaldosteronism, type I
Bronchiectasis with or without elevated sweat chloride 3
Liddle syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C015929 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|affects cotreatment|increases activity 15161604
C055656 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]affects binding|increases activity 19359370
C090860 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate results in increased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]affects binding|increases activity 19359370
C063261 acetylleucyl-leucyl-norleucinal acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNAdecreases expression 15564131
C063261 acetylleucyl-leucyl-norleucinal acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoterincreases methylation 15564131
D000450 Aldosterone Aldosterone results in increased expression of SCNN1G mRNAincreases expression 18665318
D000450 Aldosterone Aldosterone results in increased expression of SCNN1G proteinincreases expression 18665318
D000584 Amiloride Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]affects binding|decreases reaction|increases transport 18665318
D000584 Amiloride Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]affects binding|decreases activity 19359370
D000584 Amiloride Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 18665318
18398334
D000584 Amiloride Amiloride affects the activity of SCNN1G proteinaffects activity 8617496
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SCNN1G mRNAaffects expression 16483693
C013407 benzamil benzamil results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 18024548
D020126 Brefeldin A Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]]decreases expression|decreases reaction 12608646
D001965 Bromides Bromides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16027156
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of SCNN1G mRNA]decreases reaction|increases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SCNN1G proteinaffects expression 16192424
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SCNN1G mRNAdecreases expression 16644059
D002712 Chlorides Chlorides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 15161604
16027156
D003894 Deamino Arginine Vasopressin Deamino Arginine Vasopressin results in increased expression of SCNN1G mRNAincreases expression 11711512
D003907 Dexamethasone Dexamethasone results in increased expression of SCNN1G mRNAincreases expression 12682491
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of SCNN1G mRNA]decreases reaction|increases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SCNN1G mRNAincreases expression 20360939
D004280 Dobutamine Dobutamine results in increased expression of SCNN1G mRNAincreases expression 16638327
D004317 Doxorubicin Doxorubicin results in decreased expression of SCNN1G mRNAdecreases expression 15564131
D004317 Doxorubicin Doxorubicin results in increased methylation of SCNN1G promoterincreases methylation 15564131
D004967 Estrogens Estrogens affects the activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects activity|affects binding 17939260
D004967 Estrogens Estrogens affects the expression of SCNN1G mRNAaffects expression 17939260
D004967 Estrogens Estrogens affects the expression of SCNN1G proteinaffects expression 17939260
D005839 Gentamicins Gentamicins results in increased expression of SCNN1G proteinincreases expression 16850027
D006854 Hydrocortisone Hydrocortisone results in increased expression of SCNN1G mRNAincreases expression 17715387
D007454 Iodides Iodides results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16027156
D015056 1-Methyl-3-isobutylxanthine [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|affects cotreatment|increases activity 15161604
D008094 Lithium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Lithiumaffects binding|increases transport 18665318
D009566 Nitrates Nitrates results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16027156
D010100 Oxygen Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]]decreases expression|decreases reaction 12608646
D010100 Oxygen Oxygen deficiency results in decreased expression of SCNN1G proteindecreases expression 12372821
D010100 Oxygen Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]decreases expression|decreases reaction 12372821
D010126 Ozone Ozone results in decreased expression of SCNN1G mRNAdecreases expression 16716893
C060836 pioglitazone pioglitazone promotes the reaction [PPARG protein binds to SCNN1G intron]affects binding|increases reaction 16007095
C060836 pioglitazone pioglitazone results in increased expression of SCNN1G mRNAincreases expression 16007095
C006253 pirinixic acid pirinixic acid results in increased expression of SCNN1G mRNAincreases expression 18301758
D011188 Potassium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Potassiumaffects binding|increases transport 18665318
D011374 Progesterone Progesterone affects the activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects activity|affects binding 17939260
D011374 Progesterone Progesterone affects the expression of SCNN1G mRNAaffects expression 17939260
D011374 Progesterone Progesterone affects the expression of SCNN1G proteinaffects expression 17939260
D011374 Progesterone Progesterone results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]affects binding|decreases activity 16172119
D011692 Puromycin Aminonucleoside Puromycin Aminonucleoside results in decreased expression of SCNN1G mRNAdecreases expression 16020936
D012964 Sodium Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]affects binding|decreases reaction|increases transport 18665318
D012964 Sodium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein binds to SCNN1D protein] which results in increased transport of Sodiumaffects binding|increases transport 19359370
D012964 Sodium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which affects the transport of Sodiumaffects binding|affects transport 18398334
D012964 Sodium [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodiumaffects binding|increases transport 18665318
D012964 Sodium [SCNN1A protein binds to SCNN1B protein mutant form binds to SCNN1G protein] which results in increased transport of Sodiumaffects binding|increases transport 18398334
D012964 Sodium SCNN1G protein affects the transport of Sodiumaffects transport 8617496
D012964 Sodium Sodium affects the expression of SCNN1G mRNAaffects expression 15261163
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary results in decreased expression of SCNN1G proteindecreases expression 18024548
D013726 Terbutaline Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]]decreases expression|decreases reaction 12608646
D013726 Terbutaline Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]decreases expression|decreases reaction 12372821
D013890 Thiourea Thiourea results in decreased expression of SCNN1G mRNAdecreases expression 15248066
C024746 tobacco tar tobacco tar results in decreased expression of SCNN1G mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 4.5414610225
MESH:D000138 Acidosis Ammonium Chloride 3.1818287403
MESH:D058186 Acute Kidney Injury Gentamicins 4.2111274264
MESH:D055371 Acute Lung Injury Oxygen 8.0616759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.0618653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.4717418594
MESH:D000236 Adenoma Diethylnitrosamine 2.636695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.8319061943 16434500 17620307 19052882 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8316434500
MESH:D000419 Albuminuria Doxorubicin 4.1821441931
MESH:D000544 Alzheimer Disease Lithium 4.3919621015
MESH:D000544 Alzheimer Disease Ozone 4.3915513908
MESH:D000686 Amyloidosis Terbutaline 5.267986221
MESH:D000860 Anoxia Oxygen 4.6720872349
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3017659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4615570426
MESH:D001249 Asthma Ozone 2.5216373670 17854713
MESH:D050197 Atherosclerosis Oxygen 3.5816391483
MESH:D001321 Autistic Disorder pioglitazone 3.1317207275
MESH:D001321 Autistic Disorder Terbutaline 3.1316417856 17400887
MESH:D001714 Bipolar Disorder Lithium 4.1217594078 20338123 19153942 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8119483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3114601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9517868700
MESH:D001930 Brain Injuries Progesterone 3.8915845082 15665606 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.4817150277
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9817474063
MESH:D001943 Breast Neoplasms Doxorubicin 1.9815994142 16096432 15939500 19526202 15634643 16322301 15692762 16115903 16826403 15668708 18628466 18382427 15993339 16935488 16264153 15567936 16595493 17983394 15136595 18234424 18695136 11325840 17369602 17426702
MESH:D001943 Breast Neoplasms Oxygen 1.9817263869
MESH:D001943 Breast Neoplasms Progesterone 1.9816175315 15562024 17614352
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3818417511 15516495 16777450 14754758 17626835 18315731 19059883
OMIM:613071 BRONCHIECTASIS WITH OR WITHOUT ELEVATED SWEAT CHLORIDE 3 marker/mechanism
MESH:D002100 Cachexia Ozone 4.3616183385
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.479428835 11713377
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4110355542 16227642 16097048 16192424 16124888 15700767 18705752 16050911 16011737 15673190 3786805 15721981
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4216051944
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.0818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.0820514400 19701751 16935385 20524982 21159647 17978847 17428255 16807293 18665156 17138121 16698587 16502159 18056438 17173139 10672840 19052882 20432363 16328049 16540662 16569478 16779866 18210153 18691550 18506893 16878318 3084413 19107877 19394651 20101231 18393292 18494052 11831363 16830150 16288022 19919837 17761372 10737359 20084675 17162532 19519916 20935162 18785209 18788625 19539802 16681979 19171122 19822196 20727157 19335982 19208518 3581430 20512989 17055752 19418558 18971187 20214788 19383236 20007298 18978308
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.0818059187 17876044 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Estrogens 6.0815341023
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.9816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.526189445
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.7514644129
MESH:D009202 Cardiomyopathies Doxorubicin 3.2817329180 17351982 17308081 17382496 16952015 16109756 15476868 17131338 16242529 16731534 15811867 15792986 17007740 16364871 16612575 17519947 16455267 16651473 17928571 17974986 16278810 17924179 16269455 15505089 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8116243910 17334414
MESH:D002318 Cardiovascular Diseases Aldosterone 4.4611230374
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.267505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 6.2619559774
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.3719052882
MESH:D002779 Cholestasis pirinixic acid 2.5519176532
MESH:D002972 Cleft Palate Hydrocortisone 3.9915826874
MESH:D003092 Colitis Amiloride 4.7412065299
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4315824018
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003371 Cough Terbutaline 5.1819679606
MESH:D019465 Craniofacial Abnormalities Dexamethasone 3.2417728286
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 3.2417728286
MESH:D016638 Critical Illness Estrogens 5.5616670151
MESH:D003550 Cystic Fibrosis marker/mechanism 16463024
MESH:D003550 Cystic Fibrosis pioglitazone 4.6019747007
MESH:D007644 Darier Disease Lithium 5.5320338123
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0512438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.3719244398
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.6420387270
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 4.6416023994 12642470
MESH:D003929 Diabetic Neuropathies Progesterone 4.1217187935
MESH:D003967 Diarrhea Dexamethasone 7.427237001
MESH:D003967 Diarrhea Hydrocortisone 7.427237001
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.5910092053 6623471 15027814 15998439 7120509 19336974 6884620 17522070 7179309 16177239 3732212 7440962 2869522 4309450 21278145 15968718 3786805 19085960 9327722 11566570 10915739 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.5919107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.5917416283
MESH:D004362 Drug Toxicity Doxorubicin 7.7918602426
MESH:D004362 Drug Toxicity Gentamicins 7.7911033412 15033597
MESH:D004417 Dyspnea Oxygen 4.4520016425
MESH:D004485 Eczema Dexamethasone 4.1012438553
MESH:D004487 Edema Dexamethasone 5.8119703484
MESH:D004487 Edema pirinixic acid 5.8112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4217692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.2017359293
MESH:D004715 Endometriosis Progesterone 3.4416134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7718037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7316302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.1316045604 12631006 12795759 16239168 19224547 17595544 61145 15959796
MESH:D005234 Fatty Liver Diethylnitrosamine 11.1321071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 11.1319236843 20131406
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.1318705752
MESH:D005355 Fibrosis Terbutaline 8.1315467267
MESH:D005739 Gas Poisoning Oxygen 4.8320016425
MESH:D005909 Glioblastoma Doxorubicin 3.1017150277
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 4.9416687628
MESH:D006130 Growth Disorders Amiloride 4.5119703807
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.2715692506
MESH:D034381 Hearing Loss Gentamicins 4.5618024279 15968427 17868369 19130971
MESH:D006330 Heart Defects, Congenital Lithium 4.0119638421
MESH:D006331 Heart Diseases Doxorubicin 3.2216244371 14766674 16707910 16244372 18674790 16495754 16330681 18006777 12587719 17875725 16144979 16879835 17888722
MESH:D006333 Heart Failure Dobutamine 10.6117440445
MESH:D006333 Heart Failure Doxorubicin 10.6117481944
MESH:D006333 Heart Failure pirinixic acid 10.6120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5615692506
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2419110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 2.6319176532 16221962 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.937520565
MESH:D006689 Hodgkin Disease Doxorubicin 3.1015147373 18501091 17606976
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1516899240
MESH:D053565 Hypercalciuria Gentamicins 5.3217652376
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006973 Hypertension marker/mechanism 15198480
MESH:D006973 Hypertension Amiloride 8.2919344079 18524855 15174897
MESH:D006973 Hypertension Dexamethasone 8.2917042910
MESH:D006973 Hypertension Sodium Chloride, Dietary 8.2918524855
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7215338365
MESH:D006985 Hyperventilation Terbutaline 5.7010895896
MESH:D007008 Hypokalemia Terbutaline 5.7117292646
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 11.8519822448
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 11.8519822448
MESH:D007022 Hypotension marker/mechanism 11463765
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.0518306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0315869954
MESH:D007249 Inflammation Amiloride 13.7417237260
MESH:D007249 Inflammation Dexamethasone 13.7411099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 13.7418785209
MESH:D007249 Inflammation pioglitazone 13.7416908763
MESH:D007249 Inflammation Progesterone 13.7415869954
MESH:D007333 Insulin Resistance pirinixic acid 2.3816306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.2610783313
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.0518306037
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.3418842672
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 9.1215369732
MESH:D007674 Kidney Diseases Doxorubicin 9.1216775033 15699352 15369732
MESH:D007674 Kidney Diseases Gentamicins 9.1219349640 18289764 17934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8116707910
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 4.9911231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.1610219319
MESH:D053609 Lethargy Terbutaline 5.9310895896
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7716085563
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.7416766008
MESH:D056929 Liddle Syndrome marker/mechanism
MESH:D056929 Liddle Syndrome Amiloride 5.6019344079
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.8916239168 11408273 17157831 17174718 11903743 17334410 16221502 21278145 16943688
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.8919638242 18522880 18665156 20032147 18407596
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.0415876570 15925388 15730626 14748882 12445421 15052691 18156304 17708605 15996030 15650968 12958196 15959796 18429990 18472332 16033810 12389079 18210741 15818738 15338365 14716496 14724832 18472094 13678700 16116963 17525996 18317297 17640975 18277467 18205269 17823541 15673190 17481882 18251166 12666154 16027843 12445418 18279442 18054572 12586293 17976157 12741479 17565644 18166357 15370692 20821823 15931870 18395914 16015684 18481824 16011737 11481614 17869086 17900296 17698563 17766677 14512876 18418968 18006644 15057751 14620537 18705752 16136751 12667390 16638106 10355542 17922224 16248980 17761835 17714472 12649538 15123356 18263696 17944888 15362042 18395095 18187930 18339082 12609069 14716833 12546737 18412020 18376398 18420326 12632514 17631135 12632512 16192424 12898905 17721639 17557913 15893842 17805973 16097048
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 8.0416718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.0416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 8.0415052691 16484506
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.0415474484
MESH:D008106 Liver Cirrhosis, Experimental Puromycin Aminonucleoside 8.0416570917
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7117285989 16246199 15720792 16964402 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3614706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 6.5119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 6.5118978307 18648771 19850985 19690152 20118626 10737359 2422723 20101389 20583210 18754104 21047994 20137499 19073162 20405173 20434301 20492335 19551842 19254457 19256749 12771043 19427195 19426721 21071580 12112319 19294768 18644402 21167192 19812893 19255062 19638242 19642983 19499222 20501860 15175105 15885732 20452335 9163691 21278145 16942905 19833225 19996281 18977376 19090486 2862719
MESH:D008113 Liver Neoplasms pirinixic acid 6.5120007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.5215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 8.5218775883 16842330 18253720 21159647 18164116 18282651 17942915 19126423 18544905 18093689 18079962 3124819 16267830 19519916 19539802 18308698 2563599 19009564 17174075 19004024 9362446 17854601
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 8.5217085340 16842330
MESH:D008133 Long QT Syndrome Dobutamine 4.4519353679
MESH:D008171 Lung Diseases Dobutamine 7.1616638327
MESH:D008171 Lung Diseases Ozone 7.1619066396 8266340
MESH:D055370 Lung Injury Oxygen 8.1918339021
MESH:D055370 Lung Injury Ozone 8.1920417186
MESH:D008175 Lung Neoplasms Dexamethasone 4.4911195469 15824018
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.4921163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 4.496189445 17418594
MESH:D008175 Lung Neoplasms Ozone 4.498597069 7614698
MESH:D008223 Lymphoma Doxorubicin 3.1916098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1915621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.4215458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.4217203775 11408345
MESH:D008545 Melanoma Doxorubicin 2.2316827129
MESH:D008654 Mesothelioma Doxorubicin 2.9017638057
MESH:D008679 Metaplasia Ozone 4.7210496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1615792986
MESH:D052016 Mucositis Doxorubicin 4.4117415656
MESH:D009101 Multiple Myeloma Dexamethasone 3.2415867202 16118317 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.8918694830
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.329809623
MESH:D009203 Myocardial Infarction Doxorubicin 8.6515857846 19429709
MESH:D009203 Myocardial Infarction Lithium 8.6516288908
MESH:D009203 Myocardial Infarction pirinixic acid 8.6519151258
MESH:D017202 Myocardial Ischemia Dobutamine 4.7312447174
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6616411023
MESH:D009361 Neoplasm Invasiveness Amiloride 4.9414644129
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.349029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.3418259882
MESH:D009369 Neoplasms pirinixic acid 1.7717405874
MESH:D009401 Nephrosis Doxorubicin 11.6616899518 16636307
MESH:D009401 Nephrosis Puromycin Aminonucleoside 11.6615829708 11170791
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.1315640375 16889571
MESH:D009404 Nephrotic Syndrome Puromycin Aminonucleoside 9.1316020936
MESH:D009447 Neuroblastoma Doxorubicin 3.0615555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7320387270
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.7214998686
MESH:D012516 Osteosarcoma Doxorubicin 3.8115930896
MESH:D010051 Ovarian Neoplasms Progesterone 2.4016525653 17393432
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.2816540662
MESH:D010538 Peritonitis Ozone 3.7616369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7717638057
MESH:D011014 Pneumonia Ozone 4.0118381685 18007984 18929643
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.232563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3321297632
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.6818437689 15897917 16868541 16888761 16729912 15749863
MESH:D011507 Proteinuria Gentamicins 8.9415033597
MESH:D011507 Proteinuria pioglitazone 8.9416687628
MESH:D011546 Pseudohypoaldosteronism marker/mechanism 8640238
MESH:D011654 Pulmonary Edema Terbutaline 10.4710903255
MESH:D011654 Pulmonary Edema Thiourea 10.4710849556
MESH:D051437 Renal Insufficiency Doxorubicin 9.3617922066
MESH:D051437 Renal Insufficiency Gentamicins 9.3617132701 15728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 13.4518379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 13.4518339021 17627322
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 13.452878809
MESH:D012173 Retinitis Gentamicins 5.8918644591
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012509 Sarcoma Doxorubicin 3.6617203757 15675481 15625365 16767912 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.8816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4117846226
MESH:D012640 Seizures Lithium 3.7419660546
MESH:D012772 Shock, Septic Terbutaline 5.113431524
MESH:D012878 Skin Neoplasms Doxorubicin 2.7715692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1915625365 16767912 17203757
MESH:D013119 Spinal Cord Injuries Progesterone 3.9015862959 16503802
MESH:D013226 Status Epilepticus Lithium 5.4019570321 19430551 19951488
MESH:D013272 Stomach Diseases Dexamethasone 3.9415472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Dexamethasone 3.1615138204
MESH:D013398 Sudden Infant Death Oxygen 5.1612563064
MESH:D013610 Tachycardia Terbutaline 5.1410895896
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.347505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 6.3416010429 17909728
MESH:D016171 Torsades de Pointes Dobutamine 4.9719353679
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.6117653716
MESH:D014605 Uveitis Dexamethasone 4.431336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8517334414 17638931 16364871 17678736
MESH:D015837 Vestibular Diseases Gentamicins 5.1618776599
MESH:D014947 Wounds and Injuries Estrogens 4.4311172683
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04742 Taste transduction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA307
    • No data
    No data
    Releated drug ID Related drug Name
    PA449899hydrochlorothiazide
    PA448682bumetanide
    PA451733torasemide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00384 antagonist Riva-Zide 50/25mg Tablets Diuretics;Potassium-sparing Diuretics
    DB00594 blocker Riva-Amilzide 5/50 mg Sodium channel blockers;Diuretics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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