AutismKB 2.0

Annotation Detail for CCL17


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Basic Information Top
Gene Symbol:CCL17 ( A-152E5.3,ABCD-2,MGC138271,MGC138273,SCYA17,TARC )
Gene Full Name: chemokine (C-C motif) ligand 17
Band: 16q21
Quick LinksEntrez ID:6361; OMIM: 601520; Uniprot ID:CCL17_HUMAN; ENSEMBL ID: ENSG00000102970; HGNC ID: 10615
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200018IL4-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1747Helminthiasis
1807Autoimmune disease
1826Cystic fibrosis
1861Epstein-Barr virus infection
1899Eosinophilia
1841Stomach cancer
2103Lymphoproliferative disorder
2131Keratoconjunctivitis Sicca
2192Lung disease
2220Dermatitis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CCL17 mRNAaffects expression 16483693
D019819 Budesonide Budesonide results in decreased expression of CCL17 proteindecreases expression 15679716
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of CCL17 mRNAincreases expression 19925653
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CCL17 mRNAaffects cotreatment|increases expression 16054899
C014477 diflorasone diacetate diflorasone diacetate inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]decreases reaction|increases expression 15491423
C014477 diflorasone diacetate diflorasone diacetate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]increases expression|increases reaction 15491423
D004137 Dinitrochlorobenzene diflorasone diacetate inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]decreases reaction|increases expression 15491423
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of CCL17 proteinincreases expression 15491423
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CCL17 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL17 mRNAaffects cotreatment|increases expression 17942748
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CCL17 mRNAaffects cotreatment|increases expression 16054899
D007545 Isoproterenol Isoproterenol results in decreased secretion of CCL17 proteindecreases secretion 12871855
D010126 Ozone Ozone results in increased expression of CCL17 mRNAincreases expression 12763052
C006253 pirinixic acid pirinixic acid results in increased expression of CCL17 mRNAincreases expression 16985257
C442781 plant extract, Houttuynia cordata plant extract, Houttuynia cordata inhibits the reaction [[TNF protein co-treated with IL4 protein] results in increased expression of CCL17 mRNA]affects cotreatment|decreases reaction|increases expression 18325701
C442781 plant extract, Houttuynia cordata plant extract, Houttuynia cordata inhibits the reaction [[TNF protein co-treated with IL4 protein] results in increased secretion of CCL17 protein]affects cotreatment|decreases reaction|increases secretion 18325701
D015232 Dinoprostone Dinoprostone results in increased expression of CCL17 mRNAincreases expression 16303787
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CCL17 mRNAaffects cotreatment|increases expression 16054899
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL17 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCL17 mRNAincreases expression 17942748
D014051 Toluene 2,4-Diisocyanate diflorasone diacetate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]increases expression|increases reaction 15491423
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of CCL17 proteinincreases expression 15491423
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8711752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.9716835633
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 5.0317942926
MESH:D000544 Alzheimer Disease Ozone 4.4915513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.4919621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001014 Aortic Aneurysm Dinoprostone 5.6210231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.6410388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.3817659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3815885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Budesonide 8.3010893010 20004779 12113382 18489783 12604023 15136378 15572850
MESH:D001249 Asthma Ozone 8.3016373670 17854713
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 8.3016210060 15590890 15855793 19187332 7684630 170078 10797510 3040596 12684321 20032816 12585506 11742282 6091945 15590891 16792590 11467998 12762349 11077013 6091946 17015710 18394133 10934080 8156442
MESH:D001477 Bartter Syndrome Dinoprostone 5.7515976003
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001919 Bradycardia Isoproterenol 5.206740701
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4120435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.4111921183
MESH:D016535 Bronchial Hyperreactivity Ozone 8.9315516495 18315731 18417511 14754758 19059883 16777450 17626835
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 8.9315590891 8156442 12507178
MESH:D002100 Cachexia Ozone 4.7616183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D006332 Cardiomegaly Isoproterenol 7.127544033 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1218670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 4.2116192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7515861022 16919318 17110522 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 7.7519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015340226 12621046 16354765 15668235 8697196
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8519159591 17373747
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4915824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.6217728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6215322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 16.9012438553
MESH:D017449 Dermatitis, Allergic Contact diflorasone diacetate 16.9012956900
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 16.9015491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 16.9015491423 18759878 12956900
MESH:D003876 Dermatitis, Atopic marker/mechanism 18249437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 4.7917010967
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3017446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5017107852
MESH:D003967 Diarrhea Dexamethasone 8.587237001
MESH:D003967 Diarrhea Dinoprostone 8.5811488427 7237001 10446763
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004417 Dyspnea Budesonide 5.5720016425
MESH:D004485 Eczema Dexamethasone 4.4712438553
MESH:D004487 Edema Dexamethasone 16.5219703484
MESH:D004487 Edema pirinixic acid 16.5212083418
MESH:D004487 Edema rosiglitazone 16.5212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.5212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9316714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.029294722 10568697
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.668156442
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.7718447907
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.1815345470
MESH:D005234 Fatty Liver pirinixic acid 13.1819236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 13.1819196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005334 Fever Dinoprostone 4.8816997862 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9620067830
MESH:D005739 Gas Poisoning Budesonide 5.9620016425
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006333 Heart Failure Isoproterenol 7.3818097624
MESH:D006333 Heart Failure pirinixic acid 7.3820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.3116221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.3115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.077520565
MESH:D006561 Herpes Simplex plant extract, Houttuynia cordata 6.2618325701
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Dinoprostone 8.5616793879
MESH:D006930 Hyperalgesia rosiglitazone 8.5612083418
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 15.1017604070
MESH:D006967 Hypersensitivity plant extract, Houttuynia cordata 15.1018325701
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 15.1010880147 11019492
MESH:D006973 Hypertension Dexamethasone 5.2517042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2518850075 18670907
MESH:D006984 Hypertrophy Isoproterenol 5.2012791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007022 Hypotension Isoproterenol 4.806740701
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.4718306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Dexamethasone 8.4511099482 8960868
MESH:D007249 Inflammation rosiglitazone 8.4512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 7.5116306350
MESH:D007333 Insulin Resistance rosiglitazone 7.5116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.4718306037
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.7716718785
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 6.7715816358
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7715474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.7715980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7712878042
MESH:D008107 Liver Diseases Dinoprostone 3.4615816358
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 7.4918177683
MESH:D008113 Liver Neoplasms pirinixic acid 7.4920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1112151625
MESH:D008171 Lung Diseases Ozone 3.388266340 19066396
MESH:D055370 Lung Injury Ozone 3.8620417186
MESH:D008175 Lung Neoplasms Budesonide 6.6516885199 17163412 12117777
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 6.6511246140 15390079 18597497 16337739 19925653 11696405 19359593
MESH:D008175 Lung Neoplasms Dexamethasone 6.6511195469 15824018
MESH:D008175 Lung Neoplasms Ozone 6.658597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6511884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 6.691500032
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.6916827153
MESH:D008545 Melanoma Dinitrochlorobenzene 3.1912202904 17334785
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3817261469
MESH:D008679 Metaplasia Ozone 5.1410496685
MESH:D020326 Migraine without Aura Dinoprostone 5.2711304026
MESH:D009101 Multiple Myeloma Dexamethasone 3.5116118317 15744524 15867202
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.549809623
MESH:D009203 Myocardial Infarction Isoproterenol 6.0415740881 16538859 19172585 16697266 19595682 16584858 17052832
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009369 Neoplasms pirinixic acid 1.9517405874
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.751670384
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.7211077013 6091945 3040596 12585506 18394133 8156442 6091946
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.5018500342
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010538 Peritonitis Ozone 4.1416369182
MESH:D011014 Pneumonia Butylated Hydroxytoluene 11.4011893704
MESH:D011014 Pneumonia Ozone 11.4018007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111399792 11118676 11896295 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011654 Pulmonary Edema Isoproterenol 5.2810903255
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.6514606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0218379247 11700416
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.4316940033 20219652 7692837
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.1518447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.5819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.3112617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.5419075512
MESH:D012852 Sinusitis plant extract, Houttuynia cordata 6.6018325701
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.5419050374 19075512
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D013272 Stomach Diseases Dexamethasone 4.3415472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.4915138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Dexamethasone 4.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 5.1318097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.7118097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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