AutismKB 2.0

Annotation Detail for CCL20


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Basic Information Top
Gene Symbol:CCL20 ( CKb4,LARC,MIP-3a,MIP3A,SCYA20,ST38 )
Gene Full Name: chemokine (C-C motif) ligand 20
Band: 2q36.3
Quick LinksEntrez ID:6364; OMIM: 601960; Uniprot ID:CCL20_HUMAN; ENSEMBL ID: ENSG00000115009; HGNC ID: 10619
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500406Chemokine receptors bind chemokines
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1781Rheumatoid arthritis
1848Embryoma
2022Liver cancer
2038Gastritis
2181Liver metastases
2193Helicobacter infection
2196Periodontal disease
2214Malignant glioma
Desease Name
CARDIOVASCULAR
blood pressure
Desease Name
Blood pressure
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C032668 1-nitropyrene 1-nitropyrene results in increased expression of CCL20 mRNAincreases expression 19879285
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CCL20 mRNAincreases expression 19933214
C030682 3-chlorophenol 3-chlorophenol results in increased expression of CCL20 mRNAincreases expression 18486366
C033643 3-nitrofluoranthene 3-nitrofluoranthene results in increased expression of CCL20 mRNAincreases expression 19879285
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CCL20 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CCL20 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of CCL20 mRNAdecreases expression 16835338
C006632 arsenic trioxide [arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL20 mRNAaffects cotreatment|increases expression 19828696
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of CCL20 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CCL20 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of CCL20 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of CCL20 mRNAdecreases expression 16002434
D004391 Dust Dust results in increased expression of CCL20 mRNAincreases expression 17805423
D004958 Estradiol Estradiol results in decreased expression of CCL20 mRNAdecreases expression 16298037
D004958 Estradiol Estradiol results in increased expression of CCL20 mRNAincreases expression 20106945
D005419 Flavonoids Flavonoids results in increased expression of CCL20 mRNAincreases expression 18035473
C070081 fulvestrant fulvestrant results in increased expression of CCL20 mRNAincreases expression 16298037
C056507 gemcitabine gemcitabine results in increased expression of CCL20 mRNAincreases expression 17039268
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of CCL20 mRNAincreases expression 15159207
D017313 Fenretinide Fenretinide results in increased expression of CCL20 mRNAincreases expression 15958647
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of CCL20 mRNAincreases expression 15860229
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of CCL20 mRNAdecreases expression 17616710
D010126 Ozone Ozone results in increased expression of CCL20 mRNAincreases expression 17095637
18417511
D010457 Peptidoglycan Peptidoglycan results in increased expression of CCL20 mRNAincreases expression 15860229
D010457 Peptidoglycan Peptidoglycan results in increased expression of CCL20 proteinincreases expression 15191912
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CCL20 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCL20 mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene Raloxifene affects the expression of CCL20 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of CCL20 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL20 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen Tamoxifen results in decreased expression of CCL20 mRNAdecreases expression 16298037
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCL20 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CCL20 mRNAincreases expression 19933214
D014212 Tretinoin [arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL20 mRNAaffects cotreatment|increases expression 19828696
D014212 Tretinoin Tretinoin results in increased expression of CCL20 mRNAincreases expression 19828696
D014212 Tretinoin Tretinoin results in increased expression of CCL20 proteinincreases expression 19828696
D015054 Zymosan Zymosan results in increased expression of CCL20 proteinincreases expression 15191912
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.2318653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.2318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.6319825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.6320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.6311473722
MESH:D000230 Adenocarcinoma Fenretinide 9.6310697514
MESH:D000236 Adenoma Benzo(a)pyrene 2.506695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9517306315
MESH:D000419 Albuminuria Raloxifene 4.3417451421 17308373
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000544 Alzheimer Disease Ozone 4.1615513908
MESH:D000544 Alzheimer Disease Raloxifene 4.1615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000740 Anemia Zymosan 8.2418664788
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.7912569548 16251483 18414634 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 7.2116412693
MESH:D001169 Arthritis, Experimental Zymosan 7.2115142272 15188379 15944321 16872482 17659584
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4516292516
MESH:D001249 Asthma Ozone 4.6717854713 16373670
MESH:D001249 Asthma Tretinoin 4.6716456186
MESH:D050197 Atherosclerosis Arsenic 3.1012928151 19371607
MESH:D001284 Atrophy fulvestrant 4.6011514358
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.0116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.0119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.0112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.0116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001930 Brain Injuries Raloxifene 4.2216580743
MESH:D001932 Brain Neoplasms Fenretinide 4.1316187019
MESH:D001943 Breast Neoplasms marker/mechanism 16298037
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.9920146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 7.9911237771
MESH:D001943 Breast Neoplasms Estradiol 7.9914630087 18497071 17018787 19861407 12948864 17261762 17289903 16675129
MESH:D001943 Breast Neoplasms Fenretinide 7.9916601279
MESH:D001943 Breast Neoplasms fulvestrant 7.9918984771
MESH:D001943 Breast Neoplasms gemcitabine 7.9918382427 17039268
MESH:D001943 Breast Neoplasms Hexachlorobenzene 7.9915061365 12709520
MESH:D001943 Breast Neoplasms Raloxifene 7.9917242785 17952589 17049068 17261762 17440819 16912660 17595753 15572757 16837676 17893378 15775269 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 7.9918629630 19059307 20065188 17261762 18855134 19066611 20005174 19011961 18425577 20859285 16202921 17049068 19103187 19288272 19142967 16873071 19289846 19200415 18984771 17893378 15565566 18997820 19115204 16273361 11161223 18821012 19221464 19487384 18351453 16818667 19155303 17440819 20544844 21138602 20135344 19410462 15668708 19244106 21152245 19189212 17242785 20390343 19084267 18815881 19189210
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 7.9916166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4717626835 18417511 19059883 16777450 14754758 18315731 15516495
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0911589617
MESH:D002100 Cachexia Ozone 4.4816183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4515504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.3912907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.3917306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.3916217749 15553829 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.3916924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 13.3917159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.3916924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.391917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8912490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 13.5018922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.5020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.5011237771
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 13.5016274795
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.5016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 14.6018640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 14.6017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 14.6017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 6.9617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.0916973168 18022660
MESH:D002386 Cataract Tretinoin 2.9417460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.9812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9818566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.1016154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.1016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Cyclosporine 7.1219486331
MESH:D002779 Cholestasis pirinixic acid 7.1219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4012621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.409407595
MESH:D003072 Cognition Disorders Raloxifene 4.3615800139
MESH:D003092 Colitis Tretinoin 3.4517035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7320501625
MESH:D015179 Colorectal Neoplasms Fenretinide 2.7317273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.599125849 8800419 9664655 10589399 14991402 17551590 9142499 16925845 9224671 9211117
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.7519279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.7515920148 17308373 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.7519279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D004487 Edema pirinixic acid 14.5612083418
MESH:D004487 Edema Raloxifene 14.5615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.5612711302 11000095
MESH:D004487 Edema Zymosan 14.567907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.0015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.0015845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.0019031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.4419148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.4417893378 16202921 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 11.4416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.809294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1315328337 15821434 17637181
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.8912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8916530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.8916805852 15264214 15547721 15623463 16704527 16510608 15878914 15150132 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1911564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1916938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 22.1515073043
MESH:D005234 Fatty Liver Cyclosporine 22.1519224547
MESH:D005234 Fatty Liver pirinixic acid 22.1520131406 19236843
MESH:D005234 Fatty Liver Raloxifene 22.1517473493
MESH:D005234 Fatty Liver Tamoxifen 22.1514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005334 Fever Lipopolysaccharides 3.799205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9219069698
MESH:D005355 Fibrosis Cyclosporine 13.2212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2220067830
MESH:D005355 Fibrosis Tretinoin 13.2217994277
MESH:D005534 Foot Diseases Arsenic 5.296392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0116904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Fenretinide 6.8816187019
MESH:D005909 Glioblastoma Tretinoin 6.8817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.2920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2911294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.2914991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006333 Heart Failure pirinixic acid 2.3820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis Zymosan 4.4519110552
MESH:D006529 Hepatomegaly pirinixic acid 7.4119772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4116120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D051677 Histiocytoma, Malignant Fibrous 1-nitropyrene 6.946692400
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.788697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0116870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2317050553
MESH:D006973 Hypertension Arsenic 11.5416076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 11.5410903974
MESH:D006973 Hypertension Raloxifene 11.5415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.5418850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.2916093927
MESH:D007248 Infertility, Male fulvestrant 3.5811514358
MESH:D007249 Inflammation Flavonoids 14.4217296493
MESH:D007249 Inflammation Lipopolysaccharides 14.4217237260 17963957 9205823 17255318 12878042
MESH:D007249 Inflammation Tamoxifen 14.4219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.4212878042 12200463
MESH:D007249 Inflammation Zymosan 14.428014878 11289658
MESH:D007333 Insulin Resistance Estradiol 6.6316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.6316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5117994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3917255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5717553498
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1517551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007642 Keratosis Arsenic 4.7316930632 12749816
MESH:D007674 Kidney Diseases Cyclosporine 5.448314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 5.4415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1512371664
MESH:D007680 Kidney Neoplasms Estradiol 11.1515610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.1518625569
MESH:D007889 Leiomyoma Raloxifene 4.2516973256
MESH:D007938 Leukemia arsenic trioxide 5.9015070760
MESH:D007938 Leukemia Tretinoin 5.9017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.6919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6916482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7116467208 17050201 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7119850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 11.7917339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 11.7916112521 17649720 19075265 19225113 11468182 15213294 17107899 11161223 16823087 15622746 19035177 17217047 9834237 16966277 15336539 17869043 16331271 12018890 19642359 12679006 15748426 16891316 12712474 16330433 17712046
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 11.7919225113 16140955 16788101 17107899 19075265 17339181 19029980 17217047 16766008 19642359 17506722 16891316 16331271 17712046 17301526 17649720 15748426 19035177 16935935 17294898 12679006 16823087 17368321 9834237 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1016882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.4315821434
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7816707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.129224671
MESH:D008064 Lipidoses Tamoxifen 2.9717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.2812878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2818397230 16248980
MESH:D008107 Liver Diseases Arsenic 2.4811134558
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.342125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Arsenic 20.3416368122
MESH:D008113 Liver Neoplasms arsenic trioxide 20.3414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.3420195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 20.3420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 20.3416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.838603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.8320377131
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 12.831423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.8312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1515213294
MESH:D008171 Lung Diseases Ozone 3.208266340 19066396
MESH:D055370 Lung Injury Asbestos, Crocidolite 13.7617365036
MESH:D055370 Lung Injury Lipopolysaccharides 13.7621114838
MESH:D055370 Lung Injury Ozone 13.7620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.1714755239
MESH:D008175 Lung Neoplasms Arsenic 10.1717306315 19168569 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 10.1719825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.1720464547 6695378 18569708 18520028 18816296 20135361 20064080 20869020 17053015
MESH:D008175 Lung Neoplasms Ozone 10.178597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 10.1718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.1711884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5019428831
MESH:D008325 Mammary Neoplasms, Experimental 1-nitropyrene 13.026692400
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.0211408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 13.0210697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.0216827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7619453300
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Fenretinide 4.9116270382
MESH:D008545 Melanoma Tamoxifen 4.9119393235 12393984
MESH:D008545 Melanoma Tretinoin 4.9116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9215990972
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0816966607 18303189 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D008679 Metaplasia Ozone 4.8410496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1216381670
MESH:D009062 Mouth Neoplasms Fenretinide 8.1216274795
MESH:D009101 Multiple Myeloma arsenic trioxide 6.8014977855 11468182 19417148 19549372 15949261
MESH:D009101 Multiple Myeloma Raloxifene 6.8016497877
MESH:D009102 Multiple Organ Failure Zymosan 4.9610479408 17724436 10890648 15259001 12879239 15213630 15241586 18160304 12130978 15834315
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0319151258
MESH:D017202 Myocardial Ischemia Arsenic 8.3215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5916411023
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7116624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4319410462
MESH:D009369 Neoplasms Benzo(a)pyrene 10.8011141357
MESH:D009369 Neoplasms Fenretinide 10.8015958647 17353921
MESH:D009369 Neoplasms pirinixic acid 10.8017405874
MESH:D009369 Neoplasms Tretinoin 10.8016594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7319189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 14.8816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.8814600291
MESH:D009421 Nervous System Malformations Tretinoin 14.889125849
MESH:D009436 Neural Tube Defects Arsenic 11.2116620997
MESH:D009436 Neural Tube Defects arsenic trioxide 11.2110525206
MESH:D009436 Neural Tube Defects Tretinoin 11.219142499
MESH:D020078 Neurogenic Inflammation Arsenic 4.1317056641
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4116303764
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D010024 Osteoporosis Raloxifene 3.2417882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9815758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 14.0817306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.0816624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 14.0819401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.0816133793
MESH:D010051 Ovarian Neoplasms Tretinoin 14.0816936753
MESH:D010146 Pain Tretinoin 2.7016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.6315580305
MESH:D010190 Pancreatic Neoplasms Fenretinide 11.6315580305
MESH:D010190 Pancreatic Neoplasms gemcitabine 11.6311504793 18992248 17440100 16929163 18383843
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.6315976015
MESH:D010235 Paraganglioma arsenic trioxide 3.9219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9316093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7315371236 6392382 16905509
MESH:D010538 Peritonitis Ozone 9.5516369182
MESH:D010538 Peritonitis Zymosan 9.5518557954 11985352 19641140 18760300 19088179 15259001 17826846 18977430 15979727 17371808 14761945
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6310923243
MESH:D011014 Pneumonia Lipopolysaccharides 10.2212224865 11605937
MESH:D011014 Pneumonia Ozone 10.2218007984 18381685 18929643
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.279918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.2718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9311896295 11222880 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.4016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4017292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.4012479363 18247401 16644109 15754350 16289102
MESH:D011471 Prostatic Neoplasms Estradiol 2.4016740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.4017024972
MESH:D011471 Prostatic Neoplasms Raloxifene 2.4015731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4015067354
MESH:D011507 Proteinuria Arsenic 8.4721343184
MESH:D011507 Proteinuria Tretinoin 8.4716636307
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9315814490 17322281 17975199 17365031
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2116303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8616283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7116646077
MESH:D018805 Sepsis Zymosan 4.4411441115
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.6817050553 16759981 17453740 18709164 17938729 16702368 16353154 15952646 19834688 17548696 6392382
MESH:D012878 Skin Neoplasms Arsenic 16.6119538983 17029826 17050553 17976673 16251483 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 16.6119755658 10029692
MESH:D012878 Skin Neoplasms Fenretinide 16.6116467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.6116192470
MESH:D012878 Skin Neoplasms Tretinoin 16.6116467112
MESH:D013088 Spermatocele Tamoxifen 4.0316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7819457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5020155912 2093021
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.5017575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.5017261132
MESH:D020521 Stroke Raloxifene 3.6216837676
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9415821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.5519014326
MESH:D013964 Thyroid Neoplasms Tretinoin 6.5516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.8219048282
MESH:D013978 Tibial Fractures Raloxifene 12.8219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7015213294
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 18.5319429237 11144890 15987713 17976673 18640142 19322015 17306315
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.5312845720 12973940 20435036 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.5317053015
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 18.5316720286
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.5317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.538653321 17572228 16712894
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 8.9516154183
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.3416752155
MESH:D014605 Uveitis Cyclosporine 11.091336536
MESH:D014605 Uveitis Zymosan 11.0911006244
MESH:D014652 Vascular Diseases Arsenic 4.4717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:05323 Rheumatoid arthritis
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04402 - 2-Propanol, Isopropanol Solvents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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