AutismKB 2.0

Annotation Detail for CCL22


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Basic Information Top
Gene Symbol:CCL22 ( ABCD-1,DC/B-CK,MDC,MGC34554,SCYA22,STCP-1 )
Gene Full Name: chemokine (C-C motif) ligand 22
Band: 16q21
Quick LinksEntrez ID:6367; OMIM: 602957; Uniprot ID:CCL22_HUMAN; ENSEMBL ID: ENSG00000102962; HGNC ID: 10621
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1807Autoimmune disease
1861Epstein-Barr virus infection
1841Stomach cancer
2051Leukemia
2066Lung cancer
2074Asthma
2220Dermatitis
1846Pleural effusion, Malignant
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000111 Acetylcysteine Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CCL22 mRNA]decreases expression|decreases reaction 19350554
C014949 acetylhydrazine acetylhydrazine results in decreased expression of CCL22 mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CCL22 mRNAaffects expression 16483693
D001151 Arsenic CCL22 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
C006632 arsenic trioxide Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CCL22 mRNA]decreases expression|decreases reaction 19350554
C006632 arsenic trioxide [arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL22 mRNAaffects cotreatment|increases expression 19828696
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CCL22 mRNAdecreases expression 19128835
19350554
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of CCL22 proteinincreases expression 17719030
D005419 Flavonoids Flavonoids results in increased expression of CCL22 mRNAincreases expression 18035473
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CCL22 mRNAaffects cotreatment|increases expression 17183730
D008070 Lipopolysaccharides Lipopolysaccharides promotes the reaction [Shiga Toxin 2 results in increased secretion of CCL22 protein]increases reaction|increases secretion 16366002
D015232 Dinoprostone Dinoprostone results in increased expression of CCL22 mRNAincreases expression 16303787
D022641 Shiga Toxin 2 Lipopolysaccharides promotes the reaction [Shiga Toxin 2 results in increased secretion of CCL22 protein]increases reaction|increases secretion 16366002
D022641 Shiga Toxin 2 Shiga Toxin 2 results in increased secretion of CCL22 proteinincreases secretion 16366002
D012906 Smoke Smoke results in increased secretion of CCL22 proteinincreases secretion 17041012
D014212 Tretinoin [arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL22 mRNAaffects cotreatment|increases expression 19828696
D014212 Tretinoin Tretinoin results in increased expression of CCL22 mRNAincreases expression 19828696
D014212 Tretinoin Tretinoin results in increased expression of CCL22 proteinincreases expression 19828696
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CCL22 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.578875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0911850527 18653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7211798837 19825857
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.7216033868
MESH:D000236 Adenoma Dimethylnitrosamine 3.5819555203
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 5.0817942926
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001014 Aortic Aneurysm Dinoprostone 5.6710231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 5.7010388637
MESH:D020261 Arsenic Poisoning Arsenic 2.8812569548 16835338 18414634 16251483
MESH:D001169 Arthritis, Experimental Tretinoin 3.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Arsenic 3.2812928151 19371607
MESH:D001321 Autistic Disorder Valproic Acid 2.0018558336 17688650 18316065 19460635 18985861 19232924 15238991 18396377 18775368 18940202 16609825 17507914 18177632 17157402 20603192
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001477 Bartter Syndrome Dinoprostone 5.8115976003
MESH:D001714 Bipolar Disorder Valproic Acid 3.1020046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.3516206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.3516197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D001943 Breast Neoplasms Tretinoin 2.2716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3911589617
MESH:D002277 Carcinoma Dimethylnitrosamine 4.0619555203
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6217687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7217306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7216217749 14691202 15553829 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.721917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1712490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 11.0217015178
MESH:D002294 Carcinoma, Squamous Cell Arsenic 11.0217687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 11.0216033868
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 11.0216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.4815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.3618022660 16973168
MESH:D002386 Cataract Tretinoin 3.1217460283
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 7.7218226522
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 7.7216192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6716129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tretinoin 2.699407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8710525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.879664655 16925845 8800419 9211117 14991402 9224671 10589399 9142499 9125849 17551590
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8717688650 16575769 8888407
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.4219747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1515213294
MESH:D003876 Dermatitis, Atopic marker/mechanism 18249437
MESH:D003967 Diarrhea Dinoprostone 4.6111488427 7237001 10446763
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 6.6011287661
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 6.608172417
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6019641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004489 Edema, Cardiac Tretinoin 4.5618230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4817637181 15328337 15821434
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.013922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8112903497
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.8117016578
MESH:D005124 Eye Abnormalities Tretinoin 3.629664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 8.1015073043
MESH:D005234 Fatty Liver Valproic Acid 8.1019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1918558336 8888407
MESH:D005334 Fever Dinoprostone 9.8011852909 16997862
MESH:D005334 Fever Lipopolysaccharides 9.8011852909 9205823
MESH:D005355 Fibrosis Tretinoin 3.5817994277
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3316904648
MESH:D005909 Glioblastoma Tretinoin 3.0417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.929664655 14991402
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 11.4616366002
MESH:D006463 Hemolytic-Uremic Syndrome Shiga Toxin 2 11.4616366002
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006930 Hyperalgesia Dinoprostone 8.4416793879
MESH:D006930 Hyperalgesia Tretinoin 8.4416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006973 Hypertension Arsenic 2.899931084 11953799 16076760
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7016612254
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007249 Inflammation Flavonoids 5.4617296493
MESH:D007249 Inflammation Lipopolysaccharides 5.4612878042 17255318 9205823 17963957 17237260
MESH:D007410 Intestinal Diseases Tretinoin 3.8417994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.9517551590 15992940
MESH:D007642 Keratosis Arsenic 5.0712749816 16930632
MESH:D007938 Leukemia arsenic trioxide 6.4315070760
MESH:D007938 Leukemia Tretinoin 6.4317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.6619077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.6616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.1816467208 17050201 19850784 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1816294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.1817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 12.9817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.9812018890 17217047 15748426 12679006 9834237 16330433 15336539 15622746 17107899 17869043 16331271 15213294 12712474 19075265 17712046 11468182 19035177 11161223 17649720 16891316 16966277 16112521 19642359 16823087 19225113
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.9817217047 9834237 19035177 17506722 19642359 12679006 17368321 17294898 17339181 16823087 17107899 17712046 19029980 16788101 17301526 17361223 16331271 16891316 15748426 19075265 16935935 17649720 19225113 16766008 16140955
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4216882451
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 5.1515723089 18095165 18629640 17196135 15138612 16270385 16603200 17719030 17881167 12925901 15744066 15081153 15793283 18364076 17203207 16544323 15591649 18237412 16570917 15298665 17534399 15763062 14659978 15086199 18210741 17432682 15504291 14709902 17348192 15842777 16009107 12918455 17201889 17640959 18239293 15733078 16627068 15099470 15798949 15366600 15383259 18371158 17465448 17036385 18567088 17666798 16042886 15492853 15571005 15339415 14643895 15942678 15369754 15577212 15161499 15864749 17724770 18672772 14568256 18637143 17198567 15067225 15479170 16169303 14726149
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 5.1515816358
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1518397230 16248980
MESH:D008107 Liver Diseases Arsenic 4.7811134558
MESH:D008107 Liver Diseases Dinoprostone 4.7815816358
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.4617457977
MESH:D008113 Liver Neoplasms Arsenic 7.7416368122
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7414682389
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 7.743113478 15890375
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.3620377131
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 6.3615603536 6150874 1848544
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3915213294
MESH:D008171 Lung Diseases Acetylcysteine 4.0912815614
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms Arsenic 5.0617306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0611798837 19825857
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 5.0616061637 11884234 19555203
MESH:D008175 Lung Neoplasms Smoke 5.0611091918
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D008881 Migraine Disorders Valproic Acid 3.2318765137 18803445
MESH:D020326 Migraine without Aura Dinoprostone 5.3311304026
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1419417148 15949261 14977855 11468182 19549372
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.4816105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.4817596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.4817596541
MESH:D017202 Myocardial Ischemia Arsenic 4.0315371236
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0216624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 3.6014720322
MESH:D009369 Neoplasms Tretinoin 2.4316594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 3.849125849
MESH:D009436 Neural Tube Defects Acetylcysteine 23.1619446573
MESH:D009436 Neural Tube Defects Arsenic 23.1616620997
MESH:D009436 Neural Tube Defects arsenic trioxide 23.1610525206
MESH:D009436 Neural Tube Defects Tretinoin 23.169142499
MESH:D009436 Neural Tube Defects Valproic Acid 23.168888407 16359493
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.5718500342
MESH:D010051 Ovarian Neoplasms Arsenic 8.0417306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.0412452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0416936753
MESH:D010146 Pain Tretinoin 2.9516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3515580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3515976015
MESH:D010235 Paraganglioma arsenic trioxide 4.2219927285
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0715371236 6392382 16905509
MESH:D011014 Pneumonia Lipopolysaccharides 4.6411605937 12224865
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9120603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.4016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.4019131511
MESH:D011507 Proteinuria Arsenic 9.4821343184
MESH:D011507 Proteinuria Tretinoin 9.4816636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.6412752131 11422049
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.5812210543
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.0616116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.0619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0216646077
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7716876388 15475178 14763951 1511512 11044598 17978042 11738929 3137016
MESH:D012871 Skin Diseases Arsenic 2.7617938729 17548696 17453740 18709164 19834688 16702368 17050553 16759981 16353154 6392382 15952646
MESH:D012878 Skin Neoplasms Arsenic 5.9915504454 17050553 19538983 17029826 17976673 16251483
MESH:D012878 Skin Neoplasms Tretinoin 5.9916467112
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.3712587719
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4917007042
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.4916033868
MESH:D013274 Stomach Neoplasms Tretinoin 3.4917261132
MESH:D013276 Stomach Ulcer Acetylcysteine 4.0517918041
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.3519014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.3516026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0415213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3417976673 11144890 19429237 17306315 15987713 19322015 18640142
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3420435036 11780464 12845720 12973940
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7316129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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