AutismKB 2.0

Annotation Detail for PKNOX2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PKNOX2 ( FLJ13074,PREP2 )
Gene Full Name: PBX/knotted 1 homeobox 2
Band: 11q24.2
Quick LinksEntrez ID:63876; OMIM: 613066; Uniprot ID:PKNX2_HUMAN; ENSEMBL ID: ENSG00000165495; HGNC ID: 16714
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcohol dependence
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PKNOX2 mRNAaffects expression 17562736
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of PKNOX2 mRNAincreases expression 19925653
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of PKNOX2 mRNAdecreases expression 20713471
D014212 Tretinoin Tretinoin results in decreased expression of PKNOX2 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Methylcholanthrene 3.706695378 10545420
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6611922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3817474063
MESH:D001943 Breast Neoplasms Tretinoin 2.3816166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D002277 Carcinoma Methylcholanthrene 4.2910545420
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.011917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Acetaminophen 7.9210977129
MESH:D002386 Cataract Tretinoin 7.9217460283
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.7616192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 14991402 9125849 9224671 16925845 9664655 17551590 9211117 10589399 9142499
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6712153990 10915739 14550746 12958197 15619225 12392966 11461765 16109766 19416960 16177239 19420014 11287661 2444490 12705907 10774834 11421492 19164858 19085960 12540782 18071297 11739529 17522070 19923254 15968718 10663392 16781746 18713872 14725611 11529661 16485898 19739265 17906064 12594235 16227642 11743745 11834606 16393943 14986274 17562736 16081117 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D005124 Eye Abnormalities Tretinoin 3.8716938888 9664655
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.5710962813 14633661
MESH:D005355 Fibrosis Tretinoin 4.0717994277
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005909 Glioblastoma Tretinoin 3.2417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.079664655 14991402
MESH:D006930 Hyperalgesia Acetaminophen 8.7216870215
MESH:D006930 Hyperalgesia Tretinoin 8.7216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.9017604070
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.3315992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1219285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3915748426 17712046 19029980 17649720 16766008 19035177 17506722 16140955 17368321 17107899 19225113 16891316 12679006 9834237 16935935 16823087 17301526 17294898 17217047 16788101 16331271 19642359 19075265 17339181 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 12969438 16611625 19460945 11587558 19784758 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 3.4618177683
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 3.50598648 1399818
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 3.1816337739 19925653 11246140 18597497 11696405 19359593 15390079
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.181399818 17909032 16271038 6695378 7750092 15390079 20970405 11893704 9230183 10545420 16337739 21163286 20512841
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.981500032
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2817596541
MESH:D009369 Neoplasms Tretinoin 2.5716946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 3.299142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Acetaminophen 7.7516870215
MESH:D010146 Pain Tretinoin 7.7516870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.7911893704
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved