AutismKB 2.0

Annotation Detail for UBE2O


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Basic Information Top
Gene Symbol:UBE2O ( E2-230K,FLJ12878,KIAA1734 )
Gene Full Name: ubiquitin-conjugating enzyme E2O
Band: 17q25.1
Quick LinksEntrez ID:63893; OMIM: NA; Uniprot ID:UBE2O_HUMAN; ENSEMBL ID: ENSG00000175931; HGNC ID: 29554
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of UBE2O mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of UBE2O mRNAincreases expression 20106945
D014303 Trinitrotoluene Trinitrotoluene affects the expression of UBE2O mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.937525203
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 8.2810977129
MESH:D002386 Cataract Trinitrotoluene 8.2815817613 14694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.8215095906
MESH:D003490 Cyanosis Trinitrotoluene 5.5718551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.3810774834 19164858 11421492 18713872 11834606 11461765 16227642 19370779 17522070 10663392 12958197 19416960 19085960 16485898 16109766 12594235 15968718 17906064 14986274 11529661 19420014 11743745 15619225 14725611 16081117 18071297 16177239 11287661 16393943 19739265 12153990 12705907 12392966 11739529 10915739 12540782 19923254 2444490 17562736 16781746 14550746
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 4.3821346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D005234 Fatty Liver Cyclosporine 3.3419224547
MESH:D005355 Fibrosis Cyclosporine 3.7912168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006529 Hepatomegaly Trinitrotoluene 4.8815817613
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007248 Infertility, Male Trinitrotoluene 3.9512150543
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.5512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.558314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D008107 Liver Diseases Acetaminophen 1.7116610002 12969438 11587558 19460945 12587719 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009336 Necrosis Trinitrotoluene 5.5118551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009784 Occupational Diseases Trinitrotoluene 4.7814694615 12819281 17852074
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D012640 Seizures Trinitrotoluene 3.7218551238
MESH:D013163 Splenomegaly Trinitrotoluene 5.8515817613
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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