AutismKB 2.0

Annotation Detail for PRDM1


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Basic Information Top
Gene Symbol:PRDM1 ( BLIMP1,MGC118922,MGC118923,MGC118924,MGC118925,PRDI-BF1 )
Gene Full Name: PR domain containing 1, with ZNF domain
Band: 6q21
Quick LinksEntrez ID:639; OMIM: 603423; Uniprot ID:PRDM1_HUMAN; ENSEMBL ID: ENSG00000057657; HGNC ID: 9346
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
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Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
2087Bacterial infection
2239Lymphoma
Desease Name
systemic lupus erythematosus
IMMUNE
Desease Name
Systemic lupus erythematosus
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PRDM1 mRNAdecreases expression 12419474
C015001 arsenite arsenite results in decreased expression of PRDM1 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of PRDM1 mRNA]affects reaction|decreases expression 18929588
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PRDM1 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PRDM1 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PRDM1 mRNAincreases expression 20382639
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNAaffects cotreatment|increases expression 16931933
D019259 Lamivudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNAaffects cotreatment|increases expression 16931933
D019469 Indinavir [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNAaffects cotreatment|increases expression 16931933
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PRDM1 mRNAincreases expression 19237549
19675145
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PRDM1 proteinincreases expression 19675145
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 mRNA]decreases reaction|increases expression 19237549
19675145
D008070 Lipopolysaccharides Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 protein]decreases reaction|increases expression 19675145
D019258 Saquinavir [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNAaffects cotreatment|increases expression 16931933
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 mRNA]decreases reaction|increases expression 19237549
19675145
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of PRDM1 protein]decreases reaction|increases expression 19675145
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [PRDM1 protein binds to PAX5 promoter]affects binding|decreases reaction 19237549
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of PRDM1 mRNAincreases expression 16330358
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNAaffects cotreatment|increases expression 16931933
D015215 Zidovudine [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNAaffects cotreatment|increases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 15322242 11752688
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.969612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.1511850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1610965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 19898481 20453842
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8020889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 15340226 15668235 8697196 12621046
MESH:D003093 Colitis, Ulcerative marker/mechanism 21297633
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4616684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Lamivudine 14.3615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.3611462148
MESH:D004362 Drug Toxicity Zidovudine 14.3615040536
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5515328337 15821434 17637181
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver arsenite 8.6918296743
MESH:D005234 Fatty Liver Zidovudine 8.6918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005334 Fever Lipopolysaccharides 4.129205823 11852909
MESH:D005355 Fibrosis arsenite 9.2918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2920067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006402 Hematologic Diseases Zidovudine 4.8312579204
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006509 Hepatitis B Lamivudine 5.2117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2115309715 15631357 15274664 16476009 12044531
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0312621046 15340226 16120746
MESH:D015658 HIV Infections Indinavir 15.9711141242 15388451 11363243
MESH:D015658 HIV Infections Lamivudine 15.9717530837 20032539 11141242 9296927
MESH:D015658 HIV Infections Saquinavir 15.9715388451 11141242
MESH:D015658 HIV Infections Zidovudine 15.9717358032 20032539 11141242 11363243 11698656
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 8697196 15340226 16959395 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D007249 Inflammation Lipopolysaccharides 5.269205823 17237260 17255318 12878042 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2612200463 12878042
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007680 Kidney Neoplasms Zidovudine 3.8812579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5220370541
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008103 Liver Cirrhosis arsenite 3.4718296743
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4521137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.7717365036
MESH:D055370 Lung Injury Lipopolysaccharides 9.7721114838
MESH:D008175 Lung Neoplasms arsenite 4.9816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9818520028 18569708 17053015 18816296 20135361 20464547 20064080 20869020 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9819555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 4.9818800350
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 19838195
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2216966607 16166281 18303189
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009164 Mycobacterium Infections Indinavir 5.5821442799
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009389 Neovascularization, Pathologic arsenite 4.5715738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.6811550810
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0310923243
MESH:D011014 Pneumonia Lipopolysaccharides 4.7111605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0617322281 15814490 17365031 17975199
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.699296927
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6220155912 2093021
MESH:D013274 Stomach Neoplasms Zidovudine 2.6217696246
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9012579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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