AutismKB 2.0

Annotation Detail for NAPB


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Basic Information Top
Gene Symbol:NAPB ( MGC26066,MGC48335,SNAP-BETA,SNAPB )
Gene Full Name: N-ethylmaleimide-sensitive factor attachment protein, beta
Band: 20p11.21
Quick LinksEntrez ID:63908; OMIM: 611270; Uniprot ID:SNAB_HUMAN; ENSEMBL ID: ENSG00000125814; HGNC ID: 15751
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NAPB mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NAPB mRNAaffects expression 17562736
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of NAPB mRNAaffects cotreatment|decreases expression 15894712
C015001 arsenite arsenite results in decreased expression of NAPB mRNAdecreases expression 15894712
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of NAPB mRNAaffects cotreatment|decreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NAPB mRNAdecreases expression 15894712
D004041 Dietary Fats Dietary Fats results in decreased expression of NAPB mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of NAPB mRNAdecreases expression 18042831
D024505 Tocopherols Tocopherols results in increased expression of NAPB mRNAincreases expression 17654050
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0820435547
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.923581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511298694 14531868 8970840 12868966 2524372 8156756 11906362 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9418692083 7440962 9328219 9022650 16192314 18289764 8291058 1440618 6482804 18648102 9653073 6679447 11289319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9418713872 19085960 12392966 16227642 10663392 17522070 2444490 11461765 19923254 15968718 11287661 16781746 10774834 12594235 15619225 16393943 19739265 17562736 11529661 19164858 12153990 12705907 19420014 16177239 14550746 14725611 11743745 16109766 10915739 19370779 11739529 14986274 12540782 16081117 11834606 18071297 19416960 11421492 16485898 12958197 17906064
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005234 Fatty Liver arsenite 9.0318296743
MESH:D005234 Fatty Liver Dietary Fats 9.0317967931 19551842 18296743 19004024
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis arsenite 10.2618296743
MESH:D005355 Fibrosis Dietary Fats 10.2618296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2718457598 11836018
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008103 Liver Cirrhosis arsenite 7.3118296743
MESH:D008103 Liver Cirrhosis Dietary Fats 7.3118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6819784758 16610002 12969438 12587719 19014921 11587558 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1221137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.696587162 598648 3712494 1399818
MESH:D008175 Lung Neoplasms arsenite 2.6616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6618569708 17053015 18520028 20869020 20464547 20064080 18816296 20135361 6695378
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.2417927505
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Tocopherols 4.2015878867
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009389 Neovascularization, Pathologic arsenite 4.8115738583
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 2.3419632207 20518802 20132043 21332399 16723640 17217161 18674790 18457598 11836018
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.6017292933
MESH:D011471 Prostatic Neoplasms Tocopherols 3.6012504091
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.096582329 6587162 1399818 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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