AutismKB 2.0

Annotation Detail for SEC13


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Basic Information Top
Gene Symbol:SEC13 ( D3S1231E,SEC13L1,SEC13R,npp-20 )
Gene Full Name: SEC13 homolog (S. cerevisiae)
Band: 3p25.3
Quick LinksEntrez ID:6396; OMIM: 600152; Uniprot ID:SEC13_HUMAN; ENSEMBL ID: ENSG00000157020; HGNC ID: 10697
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Membrane Trafficking
No data
No data
Pathway IDPathway Name
500009COPII (Coat Protein 2) Mediated Vesicle Transport
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SEC13 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of SEC13 mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen affects the expression of SEC13 mRNAaffects expression 17562736
D002110 Caffeine Caffeine results in decreased expression of SEC13 mRNAdecreases expression 11793227
C018021 cobaltous chloride cobaltous chloride results in decreased expression of SEC13 proteindecreases expression 16622835
D016572 Cyclosporine Cyclosporine results in increased expression of SEC13 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SEC13 mRNAincreases expression 17108234
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SEC13 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of SEC13 mRNAincreases expression 19244175
D013853 Thioacetamide Thioacetamide results in decreased expression of SEC13 mRNAdecreases expression 11793227
D014810 Vitamin E Vitamin E results in increased expression of SEC13 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7619483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 9.7619483382
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.733581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.7317997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.957505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9512371664
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.4418291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 20.289022650 19486331
MESH:D002779 Cholestasis Cyclosporine 20.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 20.2817333356 16105132 15861022 11677210 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 20.2819176532
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.9918759878 2524372 8970840 14531868 12868966 8156756 11298694 11906362
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 7.9911298694 15059100 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.399653073 9328219 18289764 1440618 18692083 6679447 8291058 16192314 18648102 7440962 11289319 9022650 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3912392966 12958197 19370779 19739265 11739529 12540782 19420014 12705907 12594235 16081117 17562736 14550746 2444490 16781746 16485898 11421492 16393943 11834606 15968718 17522070 18713872 10915739 11743745 14725611 10774834 16227642 19923254 19085960 15619225 19416960 19164858 11461765 18071297 14986274 12153990 17906064 16109766 10663392 11529661 16177239 11287661
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3915131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.3912963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005218 Fat Necrosis Thioacetamide 5.9916456712
MESH:D005234 Fatty Liver Cyclosporine 14.0319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.0315345470
MESH:D005234 Fatty Liver pirinixic acid 14.0320131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure pirinixic acid 7.2820558911
MESH:D006333 Heart Failure Selenium 7.2817162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7417276928 18665440 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 17.116705139
MESH:D006505 Hepatitis Caffeine 17.1111394713
MESH:D006505 Hepatitis Thioacetamide 17.1116456712
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 19772884 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.5518776723 8314463 10903974
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.756582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7512371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.6518380797 15716488 18615449 15078482 12085344 16098781 18416461 15334695 16343077 11682029 17355460 15288473 15288472 14739098 16248980 11172339 10677585 18032466 18458672 16126171 16097051 15158331 11481614 18295389 15362042 18031379 16489207 15095483 18395095 15474484 15465738 17127702 17050028 12679928 17292413 18263696 12891558 15316131 12531686 17629604 12175628 12557150 18606216 16511523 15075984
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6516169303
MESH:D008107 Liver Diseases Acetaminophen 4.2519460945 16610002 12587719 16611625 12969438 11587558 19014921 19784758
MESH:D008107 Liver Diseases Thioacetamide 4.2516337175 15158337 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 10.1815313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms pirinixic acid 1.8720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.636587162 1399818 3712494 598648
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012893 Sleep Disorders Caffeine 5.5519395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.3617225163
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016582329 3712494 6587162 7505956 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.338074119
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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