AutismKB 2.0

Annotation Detail for SEC14L1


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Basic Information Top
Gene Symbol:SEC14L1 ( DKFZp686C06176,PRELID4A,SEC14L )
Gene Full Name: SEC14-like 1 (S. cerevisiae)
Band: 17q25.2-q25.3
Quick LinksEntrez ID:6397; OMIM: 601504; Uniprot ID:S14L1_HUMAN; ENSEMBL ID: ENSG00000129657; HGNC ID: 10698
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
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No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol SEC14L1 protein results in decreased susceptibility to 1-UFT protocoldecreases response to substance 16734730
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SEC14L1 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SEC14L1 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SEC14L1 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of SEC14L1 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of SEC14L1 mRNAincreases expression 16002434
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SEC14L1 mRNAaffects cotreatment|increases expression 17404688
D005472 Fluorouracil SEC14L1 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SEC14L1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of SEC14L1 mRNAincreases expression 18037150
18070364
C004648 testosterone enanthate testosterone enanthate affects the expression of SEC14L1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SEC14L1 mRNAincreases expression 20106945
D019772 Topotecan SEC14L1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D002762 Cholecalciferol Cholecalciferol results in increased expression of SEC14L1 mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000230 Adenocarcinoma Estradiol 4.5111473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000740 Anemia Fluorouracil 8.9415504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.1316142846
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615665606 15845082 15380490
MESH:D001943 Breast Neoplasms Calcitriol 2.3611237771
MESH:D001943 Breast Neoplasms Estradiol 2.3617289903 17261762 14630087 17018787 12948864 18497071 19861407 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 2.3615136595 16595493 19217205 16557594 18357371 16110121 18608205
MESH:D001943 Breast Neoplasms Progesterone 2.3617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7012907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7016799960 17088986 17045692 16332177 18930000 17971768
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9211237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9216280240 18986760 16757204 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.4620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 2.9719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1312621046 15668235 15340226 16354765 8697196
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417016597 16510598 17287894 17725105 17169374 15001691 16340194 18772588 17172411 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015289873 16331619 18949393 18448328 17094418 17695437 17016601 20501625 18509181 17401013 18288408 16524972 17255274 16282729 18383874 15148649 16303861 18802399 14970324 17454858 17594712 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.6315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.6317692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0319148513 18566989 11473722
MESH:D004715 Endometriosis Progesterone 9.1916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.199294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.5816481741 16785472 17638652 15173087 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16354765 16959395 18606429 15340226
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007249 Inflammation Progesterone 5.1115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.088314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.8212371664
MESH:D007680 Kidney Neoplasms Estradiol 12.8215610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.8216985049
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.6118177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Fluorouracil 7.6116603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.978603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4714755239
MESH:D008175 Lung Neoplasms Fluorouracil 3.4715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2311807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2317203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6918986760 16757204
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009369 Neoplasms Fluorouracil 2.6416928823 18239605 18600527
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.7816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D009447 Neuroblastoma Topotecan 3.8915176712
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9517393432 16525653
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6916500647 16929163 15113037 19003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1316289102 15754350 16644109 12479363 18247401
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.1317024972
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1319082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0815538739 18722050 16160472 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.718532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4016503802 15862959
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016951190 17172411 18396642 17522103 19015929 18567086 17498489 15786421 19084572 16424979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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