AutismKB 2.0

Annotation Detail for SEL1L


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Basic Information Top
Gene Symbol:SEL1L ( IBD2,PRO1063,SEL1-LIKE,SEL1L1 )
Gene Full Name: sel-1 suppressor of lin-12-like (C. elegans)
Band: 14q31
Quick LinksEntrez ID:6400; OMIM: 602329; Uniprot ID:SE1L1_HUMAN; ENSEMBL ID: ENSG00000071537; HGNC ID: 10717
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SEL1L mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SEL1L mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SEL1L mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SEL1L mRNAaffects expression 16483693
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SEL1L mRNAaffects cotreatment|affects expression 17602206
C030123 coumarin coumarin results in increased expression of SEL1L mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in increased expression of SEL1L mRNAincreases expression 20106945
C014347 decitabine [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SEL1L mRNAaffects cotreatment|decreases expression 15251184
C014347 decitabine decitabine results in decreased expression of SEL1L mRNAdecreases expression 15251184
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SEL1L mRNAaffects cotreatment|affects expression 17602206
D013749 Tetrachlorodibenzodioxin [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SEL1L mRNAaffects cotreatment|decreases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SEL1L mRNAdecreases expression 15251184
D014635 Valproic Acid Valproic Acid results in increased expression of SEL1L mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of SEL1L mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8315322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.873712494
MESH:D000236 Adenoma Diethylnitrosamine 6.8710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.5818056438 19061943 17162532 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5816835633
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001008 Anxiety Disorders Valproic Acid 9.1517497229
MESH:D001008 Anxiety Disorders vinclozolin 9.1519015723
MESH:D001321 Autistic Disorder Valproic Acid 2.0018940202 17688650 18396377 18316065 18985861 20603192 19460635 17507914 15238991 18558336 18177632 19232924 18775368 16609825 17157402
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1320046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.2515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.258888407
MESH:D001943 Breast Neoplasms decitabine 1.8719208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8717474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.707296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7016502159 20007298 10737359 3581430 17162532 17138121 16681979 19519916 16878318 18506893 18665156 18978308 19107877 17978847 20101231 18785209 16569478 19335982 19539802 20084675 20727157 21159647 19383236 17173139 19052882 20524982 18056438 17761372 18788625 16807293 20512989 16698587 16540662 19171122 19418558 11831363 10672840 19394651 3084413 20935162 19701751 16779866 16935385 16288022 19208518 19822196 19919837 17428255 18393292 16830150 20214788 18971187 18210153 20432363 20514400 18691550 18494052 17055752 16328049
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6219215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.646135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.647505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.6412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.6417174075 7505956 21159647 2727394
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.6519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.6516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.1519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 16354765 8697196 12621046 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5017688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9418759878 2524372 8970840 12868966 14531868 8156756 11906362 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 7.3519647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3520387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3517107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.6718692083 18289764 9328219 16192314 11289319 1440618 6482804 7440962 6679447 9022650 9653073 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.6719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.6720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.6719641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 18230668 15322242
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.687562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.133581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.7819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.7821071580 20387270
MESH:D005234 Fatty Liver Valproic Acid 13.7814986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16354765 8697196 18606429 16959395
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007248 Infertility, Male decitabine 7.1617581917
MESH:D007248 Infertility, Male vinclozolin 7.1616467254
MESH:D007249 Inflammation Diethylnitrosamine 5.0718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.408314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.5316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.536582329
MESH:D007680 Kidney Neoplasms Cyclosporine 18.5312371664
MESH:D007938 Leukemia decitabine 3.1219235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1117236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0618460780 19010910 17679729 18206229 19387464 18704418
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0617596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8819638242 20032147 18407596 18522880 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1217034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.037678174
MESH:D008113 Liver Neoplasms Clofibric Acid 11.0317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0319690152 20583210 18977376 19073162 2422723 21047994 18754104 10737359 19426721 2862719 18978307 9163691 15885732 21167192 20434301 19499222 19850985 21278145 19996281 20405173 20501860 12112319 18644402 20452335 19254457 19812893 19090486 19642983 15175105 19427195 19255062 12771043 20118626 16942905 18648771 19256749 19294768 21071580 19551842 19833225 20101389 20492335 19638242 20137499
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.666135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.663712494 6587162 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.6618079962 21159647 3124819 2563599 17942915 19539802 18544905 18282651 18253720 19009564 16842330 18775883 18093689 17174075 18164116 16267830 19126423 19004024 18308698 19519916 9362446 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.6612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2820970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7019010910 18608210 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.8718551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.833581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.839029167 3581430
MESH:D009369 Neoplasms decitabine 2.7619116145 17925555 19470736
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.496679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.4916359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.6812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.6816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.684026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms decitabine 2.6819259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.4819294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4816540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.2712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.272563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.1811222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 17.1820603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.1819015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012208 Rhabdomyosarcoma decitabine 11.3719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.3719155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 10.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.2518551238
MESH:D012640 Seizures Valproic Acid 10.251511512 16876388 15475178 11738929 11044598 14763951 3137016 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms decitabine 2.5519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5518456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.496587162 1399818 7505956 3712494 6582329
MESH:D013964 Thyroid Neoplasms decitabine 12.4917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.497505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.2616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.2616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.268074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.2619087683 17616700
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014689 Venous Insufficiency coumarin 5.9512708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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