AutismKB 2.0

Annotation Detail for SELPLG


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Basic Information Top
Gene Symbol:SELPLG ( CD162,CLA,PSGL-1,PSGL1 )
Gene Full Name: selectin P ligand
Band: 12q24.11
Quick LinksEntrez ID:6404; OMIM: 600738; Uniprot ID:SELPL_HUMAN; ENSEMBL ID: ENSG00000110876; HGNC ID: 10722
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05150Staphylococcus aureus infection
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200108amb2 Integrin signaling
No data
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1877Multiple sclerosis
1894Abortion
1918Atherosclerosis
2052Infection
2074Asthma
2220Dermatitis
Desease Name
Atherosclerosis
atherosclerosis, coronary
CARDIOVASCULAR
heart disease, ischemic stroke, ischemic
antiphospholipid syndrome thrombosis
IMMUNE
cerebrovascular disease
Desease Name
Conduct disorder (symptom count)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SELPLG mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in decreased expression of SELPLG mRNAdecreases expression 16982809
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SELPLG mRNAaffects expression 16483693
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of SELPLG mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of SELPLG mRNAaffects cotreatment|increases expression 18585445
D004041 Dietary Fats Dietary Fats results in decreased expression of SELPLG mRNAdecreases expression 18042831
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of SELPLG mRNAaffects cotreatment|decreases expression 17183730
C013592 mangiferin mangiferin results in decreased expression of SELPLG mRNAdecreases expression 15135318
C041786 palm oil palm oil results in decreased expression of SELPLG mRNAdecreases expression 18042831
D010622 Phencyclidine Phencyclidine results in increased expression of SELPLG mRNAincreases expression 12105081
C089730 rosiglitazone rosiglitazone results in decreased expression of SELPLG mRNAdecreases expression 16982809
D018038 Sodium Selenite Sodium Selenite results in increased expression of SELPLG mRNAincreases expression 18175754
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of SELPLG mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.608875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0119490988
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.3411874814
MESH:D000544 Alzheimer Disease rosiglitazone 2.8719621015
MESH:D000550 Amblyopia Valproic Acid 5.3717688650
MESH:D000707 Anaphylaxis mangiferin 5.5716536907 14669257
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6417497229
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D050197 Atherosclerosis mangiferin 4.1418450471
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 19460635 18316065 19232924 18558336 18940202 17507914 18396377 15238991 18177632 17157402 17688650 20603192 16609825 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.458888407
MESH:D001862 Bone Resorption mangiferin 5.009881647
MESH:D001943 Breast Neoplasms Dietary Fats 2.2820435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002386 Cataract Acetaminophen 7.8410977129
MESH:D002386 Cataract Am 580 7.8417460283
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7320734317
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D003092 Colitis Am 580 5.0617035595
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003457 Cryptosporidiosis mangiferin 5.9916547730
MESH:D003920 Diabetes Mellitus rosiglitazone 9.6717446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 9.6716285004
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 4.6619028559 12093613
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 5.2211315760 9881663
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 5.2212642470
MESH:D003928 Diabetic Nephropathies mangiferin 4.8619706694 19960420
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3711739529 16081117 12705907 17562736 12153990 11421492 11743745 16109766 17906064 11834606 10774834 16485898 11529661 14986274 18071297 16781746 18713872 14725611 14550746 12392966 16393943 16227642 12540782 11461765 10663392 12958197 11287661 19420014 19739265 12594235 15619225 19416960 19085960 15968718 19923254 10915739 19164858 2444490 16177239 19370779 17522070
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3715131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.371733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004421 Dystonia Valproic Acid 4.141851702
MESH:D004487 Edema rosiglitazone 3.7312083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.053922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.666254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.407750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.183659116
MESH:D005234 Fatty Liver Dietary Fats 19.6019551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver mangiferin 19.6015975614
MESH:D005234 Fatty Liver rosiglitazone 19.6019196556
MESH:D005234 Fatty Liver Valproic Acid 19.6019224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.238888407 18558336
MESH:D005355 Fibrosis Dietary Fats 3.6318296743
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006331 Heart Diseases mangiferin 4.4412093613
MESH:D006561 Herpes Simplex mangiferin 5.1210715843
MESH:D006849 Hydrocephalus Valproic Acid 4.9817688650
MESH:D006930 Hyperalgesia Acetaminophen 8.1016870215
MESH:D006930 Hyperalgesia rosiglitazone 8.1012083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006946 Hyperinsulinism mangiferin 5.069881663 11315760
MESH:D006949 Hyperlipidemias Dietary Fats 9.8921332399
MESH:D006949 Hyperlipidemias mangiferin 9.8915975614
MESH:D006967 Hypersensitivity mangiferin 4.7716536907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7316612254
MESH:D007154 Immune System Diseases mangiferin 5.9916076520
MESH:D007248 Infertility, Male Atrazine 3.7612948887
MESH:D007249 Inflammation Dietary Fats 8.8620412841
MESH:D007249 Inflammation mangiferin 8.8615222974
MESH:D007249 Inflammation rosiglitazone 8.8612083418
MESH:D007333 Insulin Resistance Dietary Fats 18.2011836018 18457598
MESH:D007333 Insulin Resistance mangiferin 18.2011315760
MESH:D007333 Insulin Resistance rosiglitazone 18.2016306350
MESH:D007333 Insulin Resistance Sodium Selenite 18.2014714311
MESH:D007511 Ischemia mangiferin 5.3716806951
MESH:D007674 Kidney Diseases Acetaminophen 6.5415629191 12587719
MESH:D007674 Kidney Diseases mangiferin 6.5412093613
MESH:D007859 Learning Disorders mangiferin 5.0619182383
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 4.6715498116
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1616294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.5115980055 17347453
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 12587719 16611625 16610002 19014921 11587558 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4017228818
MESH:D008175 Lung Neoplasms mangiferin 3.0518520028 18816296 18569708
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.4416827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008569 Memory Disorders mangiferin 5.0219182383
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4417261469
MESH:D008881 Migraine Disorders Valproic Acid 3.2518765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.118888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2017596541
MESH:D009203 Myocardial Infarction mangiferin 3.8816584858 16697266 16538859 17052832 19172585
MESH:D009410 Nerve Degeneration mangiferin 4.6717433543
MESH:D009436 Neural Tube Defects Valproic Acid 3.188888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Dietary Fats 2.3021332399 18457598 17217161 16723640 11836018 20518802 20132043 19632207 18674790
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010300 Parkinson Disease Atrazine 6.1117218051
MESH:D010300 Parkinson Disease mangiferin 6.1117433543
MESH:D010518 Periodontitis mangiferin 5.7419026997
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.9520603192
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3818760546
MESH:D019310 Pseudolymphoma Valproic Acid 4.6711422049 12752131
MESH:D011833 Radiation Injuries, Experimental mangiferin 6.5415830843
MESH:D012135 Respiratory Sounds Atrazine 4.6211874814
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7917978042 1511512 14763951 3137016 16876388 11044598 11738929 15475178
MESH:D012772 Shock, Septic mangiferin 5.3515177305
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6712833885
MESH:D013276 Stomach Ulcer mangiferin 4.3517918041
MESH:D014178 Translocation, Genetic Valproic Acid 5.3717262798
MESH:D014235 Trichinellosis mangiferin 6.1914669257
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.643119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.758888407
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:604 Hemostasis
KEGG:05150 Staphylococcus aureus infection
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35644
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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