Annotation Detail for SEMG1
Basic Information
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| Desease ID | Desease Name |
|---|
| 1963 | Amyloidosis |
| 2053 | Colon cancer |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000638 |
Amiodarone |
Amiodarone results in increased expression of SEMG1 mRNA | increases expression | 19774075
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of SEMG1 mRNA | affects expression | 16483693
|
| D001104 |
Arbutin |
Arbutin results in decreased expression of SEMG1 mRNA | decreases expression | 17103032
|
| C014347 |
decitabine |
decitabine affects the expression of SEMG1 mRNA | affects expression | 18468680
|
| C014347 |
decitabine |
decitabine affects the expression of SEMG1 protein | affects expression | 18468680
|
| D008727 |
Methotrexate |
SEMG1 protein affects the susceptibility to Methotrexate | affects response to substance | 16217747
|
| D015032 |
Zinc |
SEMG1 protein affects the transport of Zinc | affects transport | 17253191
|
| D015032 |
Zinc |
SEMG1 protein inhibits the reaction [Zinc results in decreased activity of KLK5 protein] | decreases activity|decreases reaction | 16517595
|
| D015032 |
Zinc |
Zinc binds to SEMG1 protein | affects binding | 16582407
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Methotrexate |
4.71 | 12039119 |
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.02 | 18287403 |
| MESH:D000169 |
Acrodermatitis |
|
Zinc |
5.87 | 17202136 16889938 17190629 |
| MESH:D000544 |
Alzheimer Disease |
|
Zinc |
2.81 | 16325427 17119284 16410023 16580781 |
| MESH:D000755 |
Anemia, Sickle Cell |
|
Zinc |
5.28 | 16916123 |
| MESH:D001145 |
Arrhythmias, Cardiac |
|
Amiodarone |
4.11 | 18057881 20041841 18218290 |
| MESH:D001172 |
Arthritis, Rheumatoid |
|
Methotrexate |
3.15 | 17286800 |
| MESH:D001249 |
Asthma |
|
Zinc |
3.03 | 17085522 |
| MESH:D001281 |
Atrial Fibrillation |
|
Amiodarone |
4.13 | 18651412 19698954 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Amiodarone |
4.22 | 19483382 |
| MESH:D001930 |
Brain Injuries |
|
Zinc |
5.11 | 17109824 |
| MESH:D001943 |
Breast Neoplasms |
|
decitabine |
2.58 | 19208741 18320071 |
| MESH:D001943 |
Breast Neoplasms |
|
Methotrexate |
2.58 | 16978400 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
decitabine |
5.24 | 19215824 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Zinc |
5.24 | 16543248 |
| MESH:D002311 |
Cardiomyopathy, Dilated |
|
Amiodarone |
2.98 | 15710769 19225199 |
| MESH:D002318 |
Cardiovascular Diseases |
|
Zinc |
3.87 | 16936243 |
| MESH:D002341 |
Carotid Artery Thrombosis |
|
Amiodarone |
5.55 | 18974383 |
| MESH:D003110 |
Colonic Neoplasms |
|
decitabine |
2.37 | 17616700 |
| MESH:D015179 |
Colorectal Neoplasms |
|
decitabine |
2.10 | 18981723 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Methotrexate |
3.26 | 12039119 9562676 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Zinc |
3.26 | 19302082 |
| MESH:D003550 |
Cystic Fibrosis |
|
Methotrexate |
4.54 | 19747007 |
| MESH:D003882 |
Dermatomyositis |
|
Methotrexate |
5.51 | 20191521 |
| MESH:D003920 |
Diabetes Mellitus |
|
Zinc |
4.49 | 16479319 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Amiodarone |
2.46 | 15265979 18218290 |
| MESH:D004701 |
Endocrine Gland Neoplasms |
|
decitabine |
5.64 | 19294695 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Zinc |
2.92 | 16543248 |
| MESH:D005234 |
Fatty Liver |
|
Amiodarone |
3.84 | 14986274 |
| MESH:D005756 |
Gastritis |
|
Zinc |
5.32 | 17241300 |
| MESH:D006086 |
Graft vs Host Disease |
|
Methotrexate |
5.57 | 16518429 |
| MESH:D006130 |
Growth Disorders |
|
Zinc |
4.15 | 17217573 |
| MESH:D006258 |
Head and Neck Neoplasms |
|
decitabine |
3.69 | 19215824 |
| MESH:D006333 |
Heart Failure |
|
Zinc |
3.78 | 17162251 |
| MESH:D006335 |
Heart Injuries |
|
Zinc |
6.29 | 17074742 |
| MESH:D016481 |
Helicobacter Infections |
|
Zinc |
4.88 | 17241300 |
| MESH:D006527 |
Hepatolenticular Degeneration |
|
Zinc |
5.11 | 17276780 |
| MESH:D006529 |
Hepatomegaly |
|
Amiodarone |
4.16 | 15265979 |
| MESH:D006937 |
Hypercholesterolemia |
|
Amiodarone |
4.20 | 9751232 8137927 |
| MESH:D007037 |
Hypothyroidism |
|
Amiodarone |
4.93 | 17991464 18020914 |
| MESH:D007248 |
Infertility, Male |
|
decitabine |
3.40 | 17581917 |
| MESH:D007511 |
Ischemia |
|
Zinc |
5.05 | 16584753 |
| MESH:D007674 |
Kidney Diseases |
|
Zinc |
3.48 | 16960431 |
| MESH:D007676 |
Kidney Failure, Chronic |
|
Zinc |
4.75 | 16518626 |
| MESH:D007805 |
Language Development Disorders |
|
Methotrexate |
5.45 | 9562676 |
| MESH:D007938 |
Leukemia |
|
decitabine |
3.21 | 19235587 18980019 |
| MESH:D007951 |
Leukemia, Myeloid |
|
decitabine |
4.33 | 17236224 19117987 18454857 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
decitabine |
2.42 | 18206229 18460780 18704418 19010910 19387464 17679729 |
| MESH:D015477 |
Leukemia, Myelomonocytic, Chronic |
|
decitabine |
5.98 | 18055864 |
| MESH:D008064 |
Lipidoses |
|
Amiodarone |
3.73 | 17567588 15342952 |
| MESH:D008103 |
Liver Cirrhosis |
|
Methotrexate |
3.85 | 14986274 |
| MESH:D008133 |
Long QT Syndrome |
|
Amiodarone |
3.82 | 15350150 17391786 11989578 |
| MESH:D008171 |
Lung Diseases |
|
Amiodarone |
3.57 | 12587719 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Amiodarone |
13.34 | 18516814 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Methotrexate |
13.34 | 18516814 |
| MESH:D008223 |
Lymphoma |
|
decitabine |
8.64 | 19470736 |
| MESH:D008223 |
Lymphoma |
|
Methotrexate |
8.64 | 17352296 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Zinc |
3.48 | 12773700 |
| MESH:D008545 |
Melanoma |
|
decitabine |
2.28 | 17785578 16505122 |
| MESH:D052016 |
Mucositis |
|
Methotrexate |
5.74 | 17488658 |
| MESH:D009101 |
Multiple Myeloma |
|
decitabine |
3.56 | 18172295 |
| MESH:D009181 |
Mycoses |
|
Amiodarone |
5.42 | 17974566 12754197 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
decitabine |
3.54 | 19157545 18608210 16882708 19010910 |
| MESH:D009369 |
Neoplasms |
|
decitabine |
2.84 | 17925555 19116145 19470736 |
| MESH:D010051 |
Ovarian Neoplasms |
|
decitabine |
2.72 | 19331143 19259094 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
decitabine |
2.85 | 19294695 |
| MESH:D011225 |
Pre-Eclampsia |
|
Zinc |
4.42 | 17114810 |
| MESH:D055728 |
Primary Myelofibrosis |
|
decitabine |
5.15 | 17616702 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Zinc |
3.77 | 16517595 16700911 12429649 16606632 |
| MESH:D011565 |
Psoriasis |
|
Methotrexate |
3.52 | 17410198 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Amiodarone |
2.95 | 12490602 11597910 12832656 |
| MESH:D051437 |
Renal Insufficiency |
|
Methotrexate |
5.13 | 17352296 |
| MESH:D012162 |
Retinal Degeneration |
|
Zinc |
4.36 | 16584753 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
decitabine |
4.75 | 19155313 |
| OMIM:609620 |
SHORT QT SYNDROME 1 |
|
Amiodarone |
5.55 | 18724381 |
| MESH:D013274 |
Stomach Neoplasms |
|
decitabine |
2.10 | 19037991 |
| MESH:D013276 |
Stomach Ulcer |
|
Amiodarone |
3.64 | 18087811 |
| MESH:D013576 |
Syndactyly |
|
Methotrexate |
5.42 | 9562676 |
| MESH:D013610 |
Tachycardia |
|
Amiodarone |
4.67 | 11238279 |
| MESH:D017180 |
Tachycardia, Ventricular |
|
Amiodarone |
4.57 | 19225199 |
| MESH:D013959 |
Thyroid Diseases |
|
Amiodarone |
5.28 | 19731979 |
| MESH:D013964 |
Thyroid Neoplasms |
|
decitabine |
3.57 | 17967635 |
| MESH:D013971 |
Thyrotoxicosis |
|
Amiodarone |
5.28 | 19584973 18020914 |
| MESH:D014062 |
Tongue Neoplasms |
|
Zinc |
4.70 | 16543248 |
| MESH:D016171 |
Torsades de Pointes |
|
Amiodarone |
4.65 | 11989578 17467628 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
decitabine |
2.82 | 17616700 19087683 |
| MESH:D014604 |
Uveal Neoplasms |
|
decitabine |
5.43 | 17785578 |
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