AutismKB 2.0

Annotation Detail for TSPYL2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TSPYL2 ( CDA1,CINAP,CTCL,DENTT,HRIHFB2216,NP79,SE204,TSPX )
Gene Full Name: TSPY-like 2
Band: Xp11.22
Quick LinksEntrez ID:64061; OMIM: 300564; Uniprot ID:TSYL2_HUMAN; ENSEMBL ID: ENSG00000184205; HGNC ID: 24358
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of TSPYL2 mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TSPYL2 mRNAincreases expression 20382639
D016572 Cyclosporine Cyclosporine results in increased expression of TSPYL2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TSPYL2 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of TSPYL2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1518218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.1618651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.2719483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1717242785 15565566 19244106 17893378 18984771 15668708 19289846 17261762 18997820 18629630 18425577 20859285 19066611 18815881 20135344 17049068 19059307 19155303 16818667 21152245 19103187 18855134 18351453 19189212 20065188 19011961 18821012 19410462 20005174 19200415 11161223 20544844 16273361 19142967 16202921 19189210 17440819 20390343 19487384 21138602 16873071 19288272 19115204 19084267 19221464
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9919225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.6218974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3512371664
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6517333356 17681005 15861022 16919318 17110522 16105132 11677210
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4618218290 15265979
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2620544844 16202921 17893378 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver Amiodarone 22.0814986274
MESH:D005234 Fatty Liver Cyclosporine 22.0819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.0815345470
MESH:D005234 Fatty Liver Tamoxifen 22.0814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006529 Hepatomegaly Amiodarone 4.2315265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.259751232 8137927
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 5.0017991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3318625569
MESH:D008064 Lipidoses Amiodarone 8.7515342952 17567588
MESH:D008064 Lipidoses Tamoxifen 8.7515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008133 Long QT Syndrome Amiodarone 3.8517391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.6012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0918516814
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8314580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009181 Mycoses Amiodarone 5.5112754197 17974566
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9612490602 11597910 12832656
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.6218724381
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D013276 Stomach Ulcer Amiodarone 3.6818087811
MESH:D013610 Tachycardia Amiodarone 4.7311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.6319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013959 Thyroid Diseases Amiodarone 5.3719731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.3418020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.7317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4616712894 8653321 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved