AutismKB 2.0

Annotation Detail for PRSS22


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Basic Information Top
Gene Symbol:PRSS22 ( BSSP-4,MGC9599,hBSSP-4 )
Gene Full Name: protease, serine, 22
Band: 16p13.3
Quick LinksEntrez ID:64063; OMIM: 609343; Uniprot ID:BSSP4_HUMAN; ENSEMBL ID: ENSG00000005001; HGNC ID: 14368
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PRSS22 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PRSS22 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRSS22 mRNAincreases expression 17351261
D010126 Ozone Ozone results in increased expression of PRSS22 mRNAincreases expression 17460151
C004648 testosterone enanthate testosterone enanthate affects the expression of PRSS22 mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000544 Alzheimer Disease Ozone 2.5015513908
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6215570426
MESH:D001249 Asthma Ozone 2.7216373670 17854713
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9619059883 18315731 17626835 15516495 14754758 16777450 18417511
MESH:D002100 Cachexia Ozone 5.2816183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.749022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7411677210 16105132 17333356 16919318 15861022 17681005 17110522
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2818759878 11906362 8970840 2524372 8156756 11298694 12868966 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9918289764 8291058 18692083 9328219 11289319 6679447 18648102 9022650 9653073 16192314 6482804 1440618 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9919164858 10663392 15619225 17522070 16109766 12958197 2444490 18713872 19923254 14986274 12392966 19739265 10774834 19085960 11743745 19416960 17562736 18071297 11739529 11461765 19420014 14725611 16393943 16781746 12540782 11421492 16081117 10915739 14550746 15968718 11529661 12153990 12594235 11287661 19370779 12705907 16485898 17906064 16177239 16227642 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6312538720
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1815345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.3617440010
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.638074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 16611625 19460945 12587719 19784758 12969438 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.731399818 3712494 598648 6587162
MESH:D008171 Lung Diseases Ozone 3.6019066396 8266340
MESH:D055370 Lung Injury Ozone 4.3320417186
MESH:D008175 Lung Neoplasms Ozone 2.107614698 8597069
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008679 Metaplasia Ozone 5.7210496685
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010538 Peritonitis Ozone 4.6116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011014 Pneumonia Ozone 4.9318929643 18381685 18007984
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D013088 Spermatocele Ethinyl Estradiol 4.5516709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.157505956 3712494 6587162 6582329 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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