AutismKB 2.0

Annotation Detail for PERP


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Basic Information Top
Gene Symbol:PERP ( KCP1,KRTCAP1,PIGPC1,RP3-496H19.1,THW,dJ496H19.1 )
Gene Full Name: PERP, TP53 apoptosis effector
Band: 6q23.3
Quick LinksEntrez ID:64065; OMIM: 609301; Uniprot ID:PERP_HUMAN; ENSEMBL ID: ENSG00000112378; HGNC ID: 17637
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
Pathway IDPathway Name
200101Direct p53 effectors
Pathway IDPathway Name
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PERP mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of PERP mRNAaffects expression 18648102
C015001 arsenite arsenite results in decreased expression of PERP mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of PERP mRNA]affects reaction|decreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PERP mRNAincreases expression 20064835
D004041 Dietary Fats Dietary Fats results in increased expression of PERP mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PERP mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PERP mRNA]decreases reaction|increases expression 17854601
D004317 Doxorubicin Doxorubicin results in increased expression of PERP mRNAincreases expression 16243910
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PERP mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PERP mRNAincreases expression 17557909
D015073 2-Acetylaminofluorene TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]affects expression|affects reaction 17317680
C482205 nutlin 3 nutlin 3 results in increased expression of PERP mRNAincreases expression 16949053
C041786 palm oil palm oil results in increased expression of PERP mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of PERP mRNAincreases expression 18301758
C059514 resveratrol resveratrol results in increased expression of PERP mRNAincreases expression 15767336
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PERP mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PERP mRNAincreases expression 17035482
18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PERP mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D058186 Acute Kidney Injury resveratrol 3.9016538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1420127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 7.1417418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1414692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 21.3610737359
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 21.363712494
MESH:D000236 Adenoma Benzo(a)pyrene 21.366695378
MESH:D000236 Adenoma Diethylnitrosamine 21.366695378 10737359
MESH:D000236 Adenoma resveratrol 21.3615688382
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.116705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.7817620307 19052882 19061943 18056438 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7816835633
MESH:D000419 Albuminuria Doxorubicin 4.6121441931
MESH:D000544 Alzheimer Disease resveratrol 2.5816162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4715885639
MESH:D001169 Arthritis, Experimental resveratrol 7.4717115116
MESH:D050197 Atherosclerosis resveratrol 3.3017967414 16873680
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8014601052
MESH:D002545 Brain Ischemia resveratrol 4.3717600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.8617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9820146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.9820435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9817474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.9811325840 18628466 18382427 16096432 15634643 16264153 16935488 15994142 17983394 15692762 17426702 15993339 16595493 18695136 18234424 16826403 16115903 15136595 17369602 16322301 15668708 15939500 15567936 19526202
MESH:D001943 Breast Neoplasms resveratrol 2.9817651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9820435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 8.993084413 10737359 3581430 6705139 17761372
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.997296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9920101231 18393292 19383236 16935385 16830150 18210153 20007298 19539802 20432363 17761372 18056438 17978847 18665156 18506893 18788625 16328049 16681979 16288022 19822196 3084413 16807293 19208518 16779866 10672840 17055752 19052882 19919837 20524982 18978308 11831363 10737359 19171122 19418558 17428255 20512989 20727157 18494052 19701751 18971187 20214788 19519916 20935162 3581430 16569478 19335982 17138121 19394651 20514400 20084675 16502159 16878318 17173139 16698587 18691550 16540662 17162532 21159647 18785209 19107877
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.9918059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.9919321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6716675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.637296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.631485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.6920419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.696189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.6916227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5617924179 16731534 17928571 18627295 17329180 17519947 16455267 16651473 16242529 17131338 15792986 17382496 16612575 17974986 15811867 16364871 16952015 16269455 16278810 16109756 17007740 15505089 17351982 15476868 17308081
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9617334414 16243910
MESH:D002318 Cardiovascular Diseases resveratrol 3.5115458977
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.817505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.8117174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.6119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 13.6116919318 17110522 17681005 17333356 16105132 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 13.6119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 12621046 15340226 15668235 8697196
MESH:D003092 Colitis resveratrol 4.2016474422
MESH:D003110 Colonic Neoplasms arsenite 4.0715037631
MESH:D003110 Colonic Neoplasms resveratrol 4.0716338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7418259882 18802399
MESH:D015179 Colorectal Neoplasms resveratrol 2.7416550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.7816507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8712868966 11906362 11298694 2524372 8970840 8156756 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8116873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.0116286809
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.118291058 6482804 18289764 9022650 18692083 9328219 9653073 1440618 16192314 6679447 18648102 11289319 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 9.1117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1120420201
MESH:D004362 Drug Toxicity Doxorubicin 8.2418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004487 Edema pirinixic acid 11.7512083418
MESH:D004487 Edema resveratrol 11.758985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.7512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.3417872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4817359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2518037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9217923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.403581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver arsenite 25.2818296743
MESH:D005234 Fatty Liver Dietary Fats 25.2818296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 25.2820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.2815345470
MESH:D005234 Fatty Liver pirinixic acid 25.2819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6719069698
MESH:D005355 Fibrosis arsenite 15.2818296743
MESH:D005355 Fibrosis Dietary Fats 15.2818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.2820067830
MESH:D005909 Glioblastoma Doxorubicin 3.3817150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5615692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.5218674790 17875725 12587719 18006777 16330681 16244372 16144979 16495754 16879835 14766674 16707910 16244371 17888722
MESH:D006333 Heart Failure Doxorubicin 7.1617481944
MESH:D006333 Heart Failure pirinixic acid 7.1620558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.416705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 9.596705139
MESH:D006394 Hemangiosarcoma Doxorubicin 9.5915692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly pirinixic acid 8.5016221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5015340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.2616876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.4515147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1418606429 8697196 16959395 15340226 16354765
MESH:D006937 Hypercholesterolemia Dietary Fats 9.4021332399
MESH:D006937 Hypercholesterolemia resveratrol 9.4017188708
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 9.4921332399
MESH:D006949 Hyperlipidemias resveratrol 9.4916873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3517488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Dietary Fats 12.2020412841
MESH:D007249 Inflammation Diethylnitrosamine 12.2018785209
MESH:D007249 Inflammation resveratrol 12.2016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.2012200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.6416624496
MESH:D007333 Insulin Resistance Dietary Fats 7.3618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.3616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.129022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Doxorubicin 3.0815369732 15699352 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2116707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.016582329
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2516085563
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6116087638
MESH:D008103 Liver Cirrhosis arsenite 11.2718296743
MESH:D008103 Liver Cirrhosis Dietary Fats 11.2718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.2720032147 18407596 18522880 18665156 19638242
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4716595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 18.2618001218 10737359 16273603 11376686 14678523 10672840
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.2621137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.2621278145 19255062 19294768 19996281 19638242 21047994 12112319 16942905 9163691 21167192 20137499 21071580 19690152 19642983 19254457 20405173 12771043 19073162 19426721 18978307 19499222 10737359 20452335 19551842 15175105 20118626 18644402 19850985 19256749 2422723 20101389 19427195 19812893 15885732 18648771 19833225 18754104 20583210 18977376 20501860 19090486 20434301 2862719 20492335
MESH:D008113 Liver Neoplasms pirinixic acid 18.2620007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 18.2619812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.2616984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 19.036150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 19.03598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.0319009564 18079962 16267830 18164116 18308698 18544905 19126423 18253720 17174075 18775883 2563599 16842330 18093689 18282651 17854601 19539802 19004024 21159647 9362446 19519916 17942915 3124819
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.0317085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.0312151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 8.6511376686
MESH:D008175 Lung Neoplasms arsenite 8.6516809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.6518569708 20869020 18816296 20064080 6695378 18520028 20135361 17053015 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.6520970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 8.656189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.6519555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.5016098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.3617088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.0317654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 9.0314749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6415621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.3315688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4315458769
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.4311606380 8985016
MESH:D008545 Melanoma Doxorubicin 3.6216827129
MESH:D008545 Melanoma resveratrol 3.6217992120
MESH:D008654 Mesothelioma Doxorubicin 3.0817638057
MESH:D008659 Metabolic Diseases resveratrol 4.4317112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5515792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D052016 Mucositis Doxorubicin 4.8717415656
MESH:D009101 Multiple Myeloma resveratrol 3.5016267019 16490592 17935668 17049120 17164350 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.9517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.6319429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 9.6319151258
MESH:D009203 Myocardial Infarction resveratrol 9.6317188708 17125593 16456233 16317513 17015251 16525036
MESH:D017202 Myocardial Ischemia resveratrol 9.1617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009205 Myocarditis resveratrol 4.8417322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.633581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.633581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.6318259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.078985016
MESH:D009389 Neovascularization, Pathologic arsenite 4.4915738583
MESH:D009401 Nephrosis Doxorubicin 4.8416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.0515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D009447 Neuroblastoma Doxorubicin 3.2915555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.6820387270
MESH:D019636 Neurodegenerative Diseases resveratrol 8.6817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.4617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009765 Obesity Dietary Fats 4.4716723640 19632207 17217161 21332399 18457598 20518802 11836018 18674790 20132043
MESH:D009765 Obesity pirinixic acid 4.4720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3117513867
MESH:D012516 Osteosarcoma Doxorubicin 4.1615930896
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2517983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.8716679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8711222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6217292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6215749863 16729912 16888761 15897917 18437689 16868541
MESH:D011471 Prostatic Neoplasms resveratrol 2.6217636462 16731767 17675339 15767336 17804756 17718901
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D051437 Renal Insufficiency Doxorubicin 4.2917922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6816325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.6519058328
MESH:D015427 Reperfusion Injury resveratrol 6.6517520802 17058453 15827377 16317513 16314181
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012509 Sarcoma Doxorubicin 4.0415675481 17203757 17710206 15625365 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3116326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8717846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.7819755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.7815692506
MESH:D012878 Skin Neoplasms resveratrol 13.788985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.7816192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6416767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.342093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3418456281
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5316321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.241399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.247505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 12.2416010429 17909728
MESH:D014062 Tongue Neoplasms resveratrol 4.2616227395
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 12.1415289314 15867355 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.148074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.1417053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 12.1417653716
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.1517473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.7214692618
MESH:D014594 Uterine Neoplasms resveratrol 9.7217044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.5817638931 17334414 17678736 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.5817488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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