AutismKB 2.0

Annotation Detail for CLSTN2


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Basic Information Top
Gene Symbol:CLSTN2 ( ALC-GAMMA,CDHR13,CS2,CSTN2,FLJ39113,FLJ39499,MGC119560,alcagamma )
Gene Full Name: calsyntenin 2
Band: 3q23
Quick LinksEntrez ID:64084; OMIM: 611323; Uniprot ID:CSTN2_HUMAN; ENSEMBL ID: ENSG00000158258; HGNC ID: 17448
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CLSTN2 mRNAdecreases expression 18648102
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CLSTN2 mRNAincreases expression 17010207
D004958 Estradiol Estradiol results in decreased expression of CLSTN2 mRNAdecreases expression 20068009
D004958 Estradiol Estradiol results in increased expression of CLSTN2 mRNAincreases expression 17010207
C002950 methylformamide methylformamide analog results in increased expression of CLSTN2 mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of CLSTN2 mRNAincreases expression 17040096
C474055 octylphenol octylphenol results in increased expression of CLSTN2 mRNAincreases expression 17010207
C025643 vinclozolin vinclozolin affects the expression of CLSTN2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8615469931
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.2517129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.2512948864 17261762 17018787 16675129 18497071 19861407 17289903 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.857296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8515948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8516924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.367505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3819486331 9022650
MESH:D003456 Cryptorchidism Diethylstilbestrol 12.6716002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 12.6714966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218156756 8970840 12868966 18759878 2524372 11298694 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318692083 11289319 9328219 18648102 6679447 9653073 8291058 6482804 18289764 16192314 7440962 9022650 1440618
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.1616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.1915700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 8.1919148513 11473722 18566989
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8316611131 15751030 16513791 16534752 16002989
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.4116452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 12.2715034207
MESH:D006965 Hyperplasia Diethylstilbestrol 12.2714722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 5.0016002989
MESH:D007246 Infertility Diethylstilbestrol 4.7415036965
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007333 Insulin Resistance Estradiol 3.1616627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases Estradiol 2.7415618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.076582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.0715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 14.0715610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4817184923
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.7316712894 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.71598648 1399818 6587162 3712494
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6115166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.0416002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7417203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.8915313581
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 11.1011399458
MESH:D009421 Nervous System Malformations Estradiol 11.1016427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0915687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 11.4217184923
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.4219015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2617136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 3.2616740699
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D013088 Spermatocele Diethylstilbestrol 5.2316002989 16709447
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126582329 3712494 7505956 1399818 6587162
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.538074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.5316452187 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.4515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.8516002989 16513791
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38239
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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