AutismKB 2.0

Annotation Detail for MCCC2


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Basic Information Top
Gene Symbol:MCCC2 ( MCCB )
Gene Full Name: methylcrotonoyl-CoA carboxylase 2 (beta)
Band: 5q13.2
Quick LinksEntrez ID:64087; OMIM: 609014; Uniprot ID:MCCB_HUMAN; ENSEMBL ID: ENSG00000131844; HGNC ID: 6937
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LEU-DEG2-PWYleucine degradation I
Pathway IDPathway Name
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
Genetic disorders
H001813-methylcrotonylglycinuria
No data
No data
No data
Desease Name
3-Methylcrotonyl-CoA carboxylase 2 deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MCCC2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MCCC2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MCCC2 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in increased expression of MCCC2 mRNAincreases expression 20678512
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MCCC2 mRNA]decreases reaction|increases expression 19172522
D016572 Cyclosporine Cyclosporine results in decreased expression of MCCC2 mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MCCC2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of MCCC2 mRNAdecreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MCCC2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCCC2 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil MCCC2 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D019833 Genistein Genistein results in increased expression of MCCC2 mRNAincreases expression 17341692
C051890 irinotecan irinotecan analog results in decreased expression of MCCC2 mRNAdecreases expression 18927307
C051890 irinotecan MCCC2 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of MCCC2 mRNA]decreases reaction|increases expression 19172522
C008493 methylselenic acid methylselenic acid results in decreased expression of MCCC2 mRNAdecreases expression 18548127
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MCCC2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MCCC2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of MCCC2 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MCCC2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MCCC2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MCCC2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:C535309 3-methylcrotonyl CoA carboxylase 2 deficiency marker/mechanism
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D054058 Acute Coronary Syndrome clopidogrel 6.0519106084
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.1511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 9.1518653653
MESH:D000230 Adenocarcinoma Estradiol 10.2511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.2514692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.2517638652
MESH:D000230 Adenocarcinoma Genistein 10.2511473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000740 Anemia Fluorouracil 8.7717963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.7711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D001943 Breast Neoplasms bisphenol A 2.3417123778
MESH:D001943 Breast Neoplasms Estradiol 2.3414630087 17289903 18497071 17261762 12948864 17018787 19861407 16675129
MESH:D001943 Breast Neoplasms Fluorouracil 2.3419217205 16595493 15136595 18608205 18357371 16557594 16110121
MESH:D001943 Breast Neoplasms Genistein 2.3416873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 8.2617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.4616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.4616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.463084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.4616924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.4618930000 17045692 17088986 16332177 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.4616924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5017066447 16757204 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases clopidogrel 7.9920180610
MESH:D002318 Cardiovascular Diseases Genistein 7.9916332659
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.266135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.2618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 13.4719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.4717681005 11677210 16919318 15861022 16105132 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 13.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9515001691 17016597 17725105 17287894 16510598 17172411 17018589 16340194 18772588 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.9517182828
MESH:D003110 Colonic Neoplasms irinotecan 5.9517287894 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7416303861 17255274 18802399 17016601 15148649 17094418 17454858 18288408 16524972 16331619 17401013 17594712 20501625 18949393 16282729 18448328 17695437 14970324 18383874 16391804 18509181 15289873
MESH:D015179 Colorectal Neoplasms irinotecan 2.7416391804 15273666 18259882 16303861 17159606 18509181 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0116485898 16781746 15619225 12958197 19370779 10915739 12705907 16227642 11739529 18071297 17562736 11834606 10663392 19164858 19420014 17906064 18713872 11421492 12392966 2444490 12540782 19739265 11529661 16177239 10774834 11287661 12153990 16109766 16393943 17522070 11743745 19416960 14550746 19085960 14725611 19923254 15968718 14986274 12594235 11461765 16081117
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2212538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.5719148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 7.5711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4515821434 17637181 15328337
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4516785472 15173087 16481741 16337965 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 13.1719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.1715345470
MESH:D005234 Fatty Liver pirinixic acid 13.1720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005334 Fever Lipopolysaccharides 4.0411852909 9205823
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D005910 Glioma Fluorouracil 2.8816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4018337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4116366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 8.4016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5017937319
MESH:D007249 Inflammation Lipopolysaccharides 5.1217237260 12878042 17963957 9205823 17255318
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1212878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 12.4216393666
MESH:D007333 Insulin Resistance Estradiol 12.4216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.4216306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6617255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0715629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.0718776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.0715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.6016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.6012371664
MESH:D007680 Kidney Neoplasms Estradiol 23.6015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.6016985049
MESH:D007938 Leukemia Genistein 3.0418980019 17468513
MESH:D007970 Leukopenia Lipopolysaccharides 4.7515821434
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.7717823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 6.7712878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6312969438 12587719 19014921 11587558 19784758 16610002 16611625 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.767678174
MESH:D008113 Liver Neoplasms Fluorouracil 10.7617045692 18383874 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 10.7620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.792876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7912151625
MESH:D055370 Lung Injury Lipopolysaccharides 4.0521114838
MESH:D008175 Lung Neoplasms Fluorouracil 2.3515246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1416891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1412929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6516757204 18986760
MESH:D052016 Mucositis irinotecan 5.0617159606
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction Genistein 5.7117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.7119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.3016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.3017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.3016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.5218551238 7678174
MESH:D009362 Neoplasm Metastasis clopidogrel 6.5811875746
MESH:D009362 Neoplasm Metastasis irinotecan 6.5818259882
MESH:D009369 Neoplasms Fluorouracil 5.0318600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 23.7816427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 23.7816427766 11399458
MESH:D009421 Nervous System Malformations Genistein 23.7816427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.7814600291
MESH:D009447 Neuroblastoma irinotecan 3.498761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.788761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6719003803 16929163 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.6011605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.6810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6811118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.6520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.6520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8816205645
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0416160472 18722050 18286688 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7510835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012170 Retinal Vein Occlusion clopidogrel 6.1619371211
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0016709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7218567086 19084572 18396642 19015929 16424979 16951190 17522103 17498489 15786421 17172411
MESH:D013274 Stomach Neoplasms irinotecan 2.7215723263
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316684133 16045194
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0516049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9016803524
MESH:D014591 Uterine Diseases bisphenol A 5.0714652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30681
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448625biotin
    PA450197l-leucine
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00121 - Biotin Dietary supplement;Micronutrient;Vitamins (Vitamin B Complex);Vitamin B Complex
    No data
    No data
    No data

    Simple Query:


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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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