AutismKB 2.0

Annotation Detail for POPDC2


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Basic Information Top
Gene Symbol:POPDC2 ( POP2 )
Gene Full Name: popeye domain containing 2
Band: 3q13.33
Quick LinksEntrez ID:64091; OMIM: 605823; Uniprot ID:POPD2_HUMAN; ENSEMBL ID: ENSG00000121577; HGNC ID: 17648
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of POPDC2 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of POPDC2 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of POPDC2 mRNAincreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of POPDC2 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of POPDC2 mRNAaffects expression 17555576
D007657 Ketone Bodies Ketone Bodies results in decreased expression of POPDC2 mRNAdecreases expression 16807920
D013629 Tamoxifen Tamoxifen affects the expression of POPDC2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 7.3719825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0520146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.0519289846 19011961 19288272 17440819 18855134 15668708 19244106 19142967 21152245 21138602 20005174 17049068 19103187 15565566 19200415 19084267 17242785 11161223 20390343 19155303 19059307 18351453 19066611 19189212 16273361 19410462 18997820 16873071 18984771 17893378 20859285 18815881 16202921 20544844 17261762 19221464 16818667 19189210 18821012 20135344 18629630 19487384 20065188 19115204 18425577
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416124888 16192424 3786805 15700767 16097048 15721981 10355542 16050911 18705752 15673190 16011737 16227642
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8816705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8814691202 15073043 16217749 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8818788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8816924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0711677210 16919318 17333356 17681005 17110522 16105132 15861022
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.117179309 19085960 6623471 16177239 3786805 16227642 11566570 7440962 10092053 19336974 3732212 2869522 21278145 9327722 15998439 15968718 6884620 4309450 7120509 17522070 15027814 10915739
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2116202921 19155303 17893378 20544844
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6316530937
MESH:D005234 Fatty Liver arsenic trioxide 21.2515073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.2516045604 16239168 61145 15959796 12631006 19224547 17595544 12795759
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.2515345470
MESH:D005234 Fatty Liver Tamoxifen 21.2519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1718625569
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 20471514 16968895 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3816891316 12018890 15213294 17217047 17712046 15748426 17649720 16330433 12712474 17107899 19075265 19225113 17869043 15336539 19035177 16331271 11468182 11161223 12679006 19642359 16112521 16966277 16823087 9834237 15622746
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9416239168 11408273 11903743 17334410 17157831 21278145 16221502 17174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5417922224 15338365 15650968 15876570 16015684 10355542 14512876 15996030 17714472 12958196 17481882 16116963 12666154 18705752 17557913 15057751 15370692 18418968 17565644 18317297 12649538 18412020 18251166 16192424 18472332 12632512 18263696 17944888 17761835 17631135 18376398 18210741 17823541 18395914 12389079 17766677 18054572 15362042 12445418 18339082 14748882 18187930 17698563 12445421 18006644 18279442 15931870 17640975 15959796 12667390 17708605 20821823 15893842 12632514 15052691 11481614 17869086 15123356 14620537 12546737 15925388 16248980 16638106 16033810 18472094 18481824 18277467 15673190 15818738 14716833 14716496 15730626 16011737 18166357 16136751 12741479 17976157 16027843 12609069 18395095 14724832 17900296 17721639 18205269 18429990 17805973 13678700 12586293 18156304 17525996 16097048 18420326 12898905
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5418564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 16964402 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.227678174
MESH:D008113 Liver Neoplasms arsenic trioxide 15.2214682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.2220195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.2219294768
MESH:D008113 Liver Neoplasms Tamoxifen 15.2216684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.822876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.8220377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.8215583823 12014681
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5711798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.576695378 20135361 18520028 18816296 17053015 18569708 20064080 20464547 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 3.5718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919417148 11468182 15949261 14977855 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.267678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 16624393 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4220155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.6916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.6912845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.6917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.6916712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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