AutismKB 2.0

Annotation Detail for SMOC2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SMOC2 ( MST117,MSTP117,MSTP140,SMAP2,bA270C4A.1,bA37D8.1,dJ421D16.1 )
Gene Full Name: SPARC related modular calcium binding 2
Band: 6q27
Quick LinksEntrez ID:64094; OMIM: 607223; Uniprot ID:SMOC2_HUMAN; ENSEMBL ID: ENSG00000112562; HGNC ID: 20323
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
vitiligo
IMMUNE
Desease Name
Vitiligo
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of SMOC2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of SMOC2 mRNA]affects expression|affects reaction 19414516
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of SMOC2 mRNA]affects expression|affects reaction 19414516
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SMOC2 mRNAdecreases expression 19146932
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SMOC2 mRNAaffects expression 17484886
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of SMOC2 mRNAincreases expression 17654400
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of SMOC2 mRNAincreases expression 17490981
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SMOC2 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMOC2 mRNA]decreases reaction|increases expression 17854601
D005480 Flurbiprofen Flurbiprofen results in decreased expression of SMOC2 mRNAdecreases expression 16949054
D010656 Phenylephrine Phenylephrine results in decreased expression of SMOC2 mRNAdecreases expression 18158353
D011374 Progesterone Progesterone affects the expression of SMOC2 mRNAaffects expression 17251523
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SMOC2 mRNAdecreases expression 19146932
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.896695378
MESH:D000236 Adenoma Diethylnitrosamine 6.8910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7116434500 19052882 19061943 18056438 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 5.2010680582
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2417460149
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001919 Bradycardia Phenylephrine 4.7415306635
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9517474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Progesterone 1.9515562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516050911 15673190 16097048 15700767 16192424 3786805 18705752 16227642 16124888 15721981 10355542 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0720512989 18393292 16569478 19394651 19107877 19919837 16540662 3581430 10672840 18785209 16935385 19701751 18056438 16878318 19383236 20007298 18494052 18506893 17055752 19052882 20101231 20524982 16681979 16807293 10737359 20727157 20432363 18210153 17162532 19519916 18691550 17428255 20214788 17761372 21159647 17138121 19208518 19171122 11831363 16328049 19822196 17978847 18978308 3084413 19418558 19539802 16779866 20084675 18971187 19335982 16698587 20514400 16830150 16502159 18665156 20935162 17173139 18788625 16288022
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Phenylephrine 7.1217124262 15728586 11754973 11179087 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1218850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.957505956 21159647 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 16354765 12621046 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.3421278145 6884620 7440962 10092053 10915739 3786805 16177239 7120509 9327722 3732212 6623471 19336974 19085960 7179309 16227642 2869522 4309450 15027814 11566570 17522070 15968718 15998439
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 9.3417654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.3419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D004715 Endometriosis Progesterone 9.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.3710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.3015959796 19224547 12795759 61145 12631006 17595544 16045604 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3021071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0712621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Phenylephrine 5.4612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D006984 Hypertrophy Phenylephrine 4.6918502941 12791704
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation Diethylnitrosamine 12.6018785209
MESH:D007249 Inflammation Flurbiprofen 12.6011099482
MESH:D007249 Inflammation Progesterone 12.6015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.6012200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8511408273 16943688 16239168 11903743 21278145 17174718 17157831 17334410 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8520032147 18407596 19638242 18522880 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3212667390 16097048 18187930 17922224 17631135 18006644 14716833 17557913 12445421 17823541 12609069 17805973 17525996 14724832 16192424 16638106 17766677 15893842 13678700 17698563 10355542 17565644 18263696 18317297 18429990 18395914 17708605 15925388 12586293 15931870 18156304 14716496 15673190 16011737 15362042 18054572 16027843 12389079 17761835 16015684 18420326 18705752 12632512 15818738 12741479 15057751 12632514 15052691 18205269 20821823 17721639 12898905 18339082 16033810 15876570 17869086 15996030 18472332 15730626 12445418 12958196 18412020 17640975 12546737 17976157 17900296 15123356 17481882 18279442 18166357 18418968 14748882 18395095 16136751 15959796 15650968 11481614 17714472 14512876 18481824 18251166 18277467 17944888 16248980 15338365 18472094 16116963 14620537 18376398 18210741 12649538 12666154 15370692
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1816246199 15830285 17285989 15720792 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1817034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0819642983 16942905 2862719 19499222 19551842 20405173 19255062 9163691 19254457 19638242 20118626 19256749 20583210 19426721 20101389 20492335 19850985 20452335 21167192 19812893 19996281 21278145 19090486 18754104 18648771 19690152 18978307 12112319 18977376 10737359 15885732 18644402 21071580 19833225 15175105 19427195 20434301 20137499 20501860 12771043 19073162 19294768 2422723 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.2915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.2918282651 18164116 2563599 18544905 19004024 18093689 16842330 19539802 21159647 17942915 17174075 19126423 19519916 18775883 9362446 19009564 18308698 18253720 17854601 16267830 18079962 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2912151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4217053015 20064080 20464547 18816296 18520028 20135361 20869020 6695378 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4220970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4211884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9517203775 11408345
MESH:D020326 Migraine without Aura Cyclic AMP 5.3211304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D010051 Ovarian Neoplasms Progesterone 2.5617393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.6217292933
MESH:D011471 Prostatic Neoplasms Flurbiprofen 3.6217409433
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012852 Sinusitis Phenylephrine 4.907327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.362093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved