AutismKB 2.0

Annotation Detail for TMBIM1


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Basic Information Top
Gene Symbol:TMBIM1 ( LFG3,MST100,MSTP100,RECS1 )
Gene Full Name: transmembrane BAX inhibitor motif containing 1
Band: 2q35
Quick LinksEntrez ID:64114; OMIM: 610364; Uniprot ID:TMBI1_HUMAN; ENSEMBL ID: ENSG00000135926; HGNC ID: 23410
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMBIM1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of TMBIM1 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of TMBIM1 mRNAaffects expression 19483382
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMBIM1 mRNAaffects expression 17484886
D002994 Clofibrate Clofibrate affects the expression of TMBIM1 mRNAaffects expression 19483382
D002995 Clofibric Acid Clofibric Acid affects the expression of TMBIM1 mRNAaffects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TMBIM1 mRNAincreases expression 19638242
D005001 Ethionine Ethionine affects the expression of TMBIM1 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of TMBIM1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid results in decreased expression of TMBIM1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid affects the expression of TMBIM1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of TMBIM1 mRNAaffects expression 19483382
C004648 testosterone enanthate testosterone enanthate affects the expression of TMBIM1 mRNAaffects expression 17440010
D013853 Thioacetamide Thioacetamide affects the expression of TMBIM1 mRNAaffects expression 19483382
D014810 Vitamin E Vitamin E results in increased expression of TMBIM1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000236 Adenoma Diethylnitrosamine 2.886695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3719052882 19061943 16434500 17162532 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3716434500
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8520041841 18057881 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 3.9418651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 51.9519483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 51.9519483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 51.9519483382
MESH:D001778 Blood Coagulation Disorders Ethionine 51.9519483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 51.9519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 51.9519483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 51.9519483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 51.9519483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.1815721981 16050911 16227642 16011737 15673190 18705752 15700767 16124888 10355542 3786805 16192424 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.1816050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.983084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 8.981701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.9818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.9819107877 19822196 17162532 19919837 19418558 19208518 20727157 19701751 20101231 16569478 18665156 17055752 16502159 16878318 18691550 17428255 18971187 3581430 18978308 21159647 16681979 18210153 16779866 3084413 16698587 18506893 16830150 16807293 11831363 20524982 19383236 18785209 20432363 19519916 18056438 19394651 20512989 20935162 16328049 19335982 20514400 10672840 16540662 17138121 10737359 19171122 18494052 19052882 18393292 17978847 20214788 19539802 20084675 18788625 17761372 20007298 17173139 16288022 16935385
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.9817997003
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9115710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 7.091399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0917174075 2727394 21159647 7505956
MESH:D002637 Chest Pain Omeprazole 5.2015447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9019052882
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.9018291259
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2015619225 14725611 10774834 17906064 17522070 12705907 11421492 14550746 11834606 11529661 15968718 14986274 16393943 11739529 2444490 18071297 19923254 12540782 16485898 19416960 16081117 11287661 16227642 19739265 19370779 11743745 19085960 16781746 16177239 10915739 12958197 11461765 12392966 18713872 12594235 10663392 12153990 17562736 19164858 19420014 16109766
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.2018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.203786805 10915739 9327722 6884620 17522070 10092053 19085960 21278145 3732212 6623471 15968718 15998439 4309450 7179309 16227642 15027814 19336974 2869522 7440962 11566570 7120509 16177239
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2019107877
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 12.2012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.3916613094 15991576 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 4.1016707586
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005218 Fat Necrosis Thioacetamide 5.8216456712
MESH:D005234 Fatty Liver Amiodarone 25.3014986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 25.3019224547 15959796 12631006 17595544 61145 16045604 12795759 16239168
MESH:D005234 Fatty Liver Clofibrate 25.3019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 25.3021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 25.3019236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5318705752
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0116080930
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6315929193 17276928 18665440
MESH:D006505 Hepatitis Carbon Tetrachloride 9.7019900420 19110552
MESH:D006505 Hepatitis Thioacetamide 9.7016456712
MESH:D006529 Hepatomegaly Amiodarone 8.8215265979
MESH:D006529 Hepatomegaly pirinixic acid 8.8218467677 16221962 19176532 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8417440010
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.939751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007037 Hypothyroidism Amiodarone 11.8618020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.8618031379 8137927
MESH:D007249 Inflammation Diethylnitrosamine 2.4018785209
MESH:D007251 Influenza, Human Vitamin E 4.3116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007674 Kidney Diseases Acetaminophen 6.0615629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.0612488133
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1419248655
MESH:D008064 Lipidoses Amiodarone 3.5515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7016221502 16239168 17174718 21278145 11408273 17157831 16943688 11903743 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7020032147 18407596 18665156 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0310355542 12649538 18205269 18210741 12667390 17565644 18156304 18395095 15996030 11481614 14716833 20821823 12741479 16097048 12958196 18166357 18339082 15650968 12898905 18412020 17721639 18317297 12546737 16015684 18251166 18054572 12586293 14512876 18418968 17708605 13678700 18395914 16192424 15931870 17631135 14620537 15123356 15370692 18376398 12666154 17640975 18006644 18429990 17805973 18187930 16033810 17714472 17698563 15362042 17922224 18263696 15338365 16027843 12389079 12632512 15893842 17557913 12632514 17525996 16011737 15818738 17869086 18279442 15925388 15959796 18472332 17766677 12445418 15876570 18705752 12445421 18481824 15730626 14716496 17481882 16638106 17900296 14748882 18420326 12609069 15673190 16136751 15052691 17823541 17976157 14724832 17944888 18277467 16116963 16248980 18472094 17761835 15057751
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 5.0316511523 18263696 12891558 18395095 16097051 16248980 16343077 15075984 17355460 17629604 12557150 17292413 10677585 12531686 12085344 18032466 15362042 18295389 15465738 16126171 16489207 15316131 12175628 18031379 15288472 11481614 18615449 14739098 18606216 15334695 15158331 18380797 17127702 16098781 17050028 15078482 15474484 11682029 15288473 15716488 12679928 18458672 11172339 18416461 15095483
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0316169303
MESH:D008107 Liver Diseases Acetaminophen 9.5119014921 11587558 19460945 12587719 19784758 16611625 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.5116246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 9.5117034775
MESH:D008107 Liver Diseases Thioacetamide 9.5118374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 16.5617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 16.5614706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 16.5615633222 12479984 17276928 15313186
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.8819294768
MESH:D008113 Liver Neoplasms Clofibric Acid 10.8817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.8821071580 21047994 2422723 10737359 20583210 19499222 21167192 19427195 19850985 19638242 19551842 16942905 19996281 21278145 19642983 20405173 20501860 20492335 19073162 18754104 19090486 18648771 19255062 18644402 18978307 9163691 19294768 19690152 20118626 20101389 2862719 18977376 15885732 12112319 20434301 20452335 12771043 20137499 19256749 15175105 19426721 19833225 19254457 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 10.8815890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.0612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.069362446 19126423 19004024 18164116 18308698 19539802 17854601 18253720 16842330 17942915 2563599 3124819 18282651 18093689 19519916 19009564 21159647 18775883 16267830 18544905 17174075 18079962
MESH:D008133 Long QT Syndrome Amiodarone 3.6215350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 7.6412587719
MESH:D008171 Lung Diseases Vitamin E 7.6416863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5120512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Vitamin E 2.5111062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009181 Mycoses Amiodarone 5.0017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.019802331
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8711597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D013272 Stomach Diseases Omeprazole 4.6918545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 7.7618087811
MESH:D013276 Stomach Ulcer Omeprazole 7.7611906479 18237397 17977527 16755016 15991576 10750652
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2519225199
MESH:D013959 Thyroid Diseases Amiodarone 4.8519731979
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.557505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.5515710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9318020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.2711989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.0310982225
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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