AutismKB 2.0

Annotation Detail for SLC39A8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC39A8 ( BIGM103,LZT-Hs6,ZIP8 )
Gene Full Name: solute carrier family 39 (zinc transporter), member 8
Band: 4q24
Quick LinksEntrez ID:64116; OMIM: 608732; Uniprot ID:S39A8_HUMAN; ENSEMBL ID: ENSG00000138821; HGNC ID: 20862
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500356Zinc influx into cells by the SLC39 gene family
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SLC39A8 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC39A8 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC39A8 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone affects the expression of SLC39A8 mRNAaffects expression 19483382
D001151 Arsenic Arsenic results in decreased expression of SLC39A8 mRNAdecreases expression 19654921
D001553 Benzbromarone Benzbromarone affects the expression of SLC39A8 mRNAaffects expression 19483382
D001639 Bicarbonates Bicarbonates promotes the reaction [SLC39A8 protein results in increased uptake of Cadmium]increases reaction|increases uptake 16638970
D001639 Bicarbonates SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]affects cotreatment|increases uptake 16638970
C006780 bisphenol A bisphenol A results in increased expression of SLC39A8 mRNAincreases expression 16474171
D002104 Cadmium Bicarbonates promotes the reaction [SLC39A8 protein results in increased uptake of Cadmium]increases reaction|increases uptake 16638970
D002104 Cadmium Manganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]decreases reaction|increases uptake 16638970
D002104 Cadmium Mercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]decreases reaction|increases uptake 16638970
D002104 Cadmium Potassium Cyanide inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]decreases reaction|increases uptake 16638970
D002104 Cadmium SLC39A8 protein affects the susceptibility to Cadmiumaffects response to substance 16638970
D002104 Cadmium SLC39A8 protein results in increased uptake of Cadmiumincreases uptake 16638970
D002994 Clofibrate Clofibrate affects the expression of SLC39A8 mRNAaffects expression 19483382
C017180 decamethrin decamethrin results in decreased expression of SLC39A8 mRNAdecreases expression 19017407
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SLC39A8 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of SLC39A8 mRNAincreases expression 16474171
D004958 Estradiol Estradiol results in increased expression of SLC39A8 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC39A8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC39A8 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of SLC39A8 mRNAaffects expression 19483382
D019833 Genistein Genistein results in increased expression of SLC39A8 mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of SLC39A8 mRNAincreases expression 15289156
D008345 Manganese Manganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]decreases reaction|increases uptake 16638970
D008345 Manganese SLC39A8 protein results in increased uptake of Manganeseincreases uptake 16638970
D008345 Manganese SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]affects cotreatment|increases uptake 16638970
D008628 Mercury Mercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]decreases reaction|increases uptake 16638970
C002950 methylformamide methylformamide analog results in increased expression of SLC39A8 mRNAincreases expression 17040096
C002950 methylformamide methylformamide results in increased expression of SLC39A8 mRNAincreases expression 17040096
D009853 Omeprazole Omeprazole affects the expression of SLC39A8 mRNAaffects expression 19483382
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC39A8 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid affects the expression of SLC39A8 mRNAaffects expression 19483382
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of SLC39A8 mRNAincreases expression 16474171
D011190 Potassium Cyanide Potassium Cyanide inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]decreases reaction|increases uptake 16638970
D011441 Propylthiouracil Propylthiouracil affects the expression of SLC39A8 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC39A8 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC39A8 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC39A8 mRNAdecreases expression 18796159
D013853 Thioacetamide Thioacetamide affects the expression of SLC39A8 mRNAaffects expression 19483382
D019772 Topotecan SLC39A8 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D015032 Zinc SLC39A8 protein results in increased transport of Zincincreases transport 18326752
D015032 Zinc Zinc results in decreased expression of SLC39A8 mRNAdecreases expression 17085522
D015032 Zinc SLC39A8 protein results in increased uptake of Zincincreases uptake 17126599
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6111752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000169 Acrodermatitis Zinc 5.1617190629 17202136 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8918653653
MESH:D000230 Adenocarcinoma Estradiol 6.6911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6914692618
MESH:D000230 Adenocarcinoma Genistein 6.6911473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0816835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9617306315
MESH:D000544 Alzheimer Disease Zinc 2.7016580781 16325427 16410023 17119284
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.6716916123
MESH:D000756 Anemia, Sideroblastic Manganese 4.6416910769
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5918057881 18218290 20041841
MESH:D020261 Arsenic Poisoning Arsenic 2.8012569548 16835338 16251483 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5115885639
MESH:D001249 Asthma Zinc 2.8817085522
MESH:D050197 Atherosclerosis Arsenic 6.5519371607 12928151
MESH:D050197 Atherosclerosis Cadmium 6.5515687053
MESH:D001281 Atrial Fibrillation Amiodarone 3.7219698954 18651412
MESH:D001321 Autistic Disorder Mercury 2.8017497416
MESH:D001327 Autoimmune Diseases Mercury 4.6316634805
MESH:D001778 Blood Coagulation Disorders Amiodarone 53.9819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 53.9819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 53.9819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 53.9819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 53.9819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 53.9819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 53.9819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 53.9812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 53.9819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001862 Bone Resorption bisphenol A 3.6411985600
MESH:D001930 Brain Injuries Zinc 4.4517109824
MESH:D001943 Breast Neoplasms bisphenol A 2.2617123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.2615324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.2617018787 16675129 19861407 12948864 17261762 14630087 17289903 18497071
MESH:D001943 Breast Neoplasms Genistein 2.2617200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.2016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.2016705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 16.2016507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 16.201701930
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.2015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.2016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.2016924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 16.2017997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.7417123778
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7815504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.7816543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8618640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2318670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.8815710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.8810334427
MESH:D002318 Cardiovascular Diseases Arsenic 11.3115738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases Genistein 11.3116332659
MESH:D002318 Cardiovascular Diseases Zinc 11.3116936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.1018022660 16973168
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8418974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.726135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.7217332340
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.721399818
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.7218566989
MESH:D002637 Chest Pain Omeprazole 4.8615447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.8618291259
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1516919318 17333356 16105132 15861022 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 7.1519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0015340226 15668235 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.2517182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7215531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8514669216 17141729
MESH:D019465 Craniofacial Abnormalities decamethrin 3.8519861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 3.8519302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3212952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0918551238
MESH:D003704 Dementia Polychlorinated Biphenyls 4.4816140633
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.5616823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3118249437
MESH:D003920 Diabetes Mellitus Zinc 4.0016479319
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.2121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.2115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 11.2112963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1015991576 16613094 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.8916707586
MESH:D004487 Edema pirinixic acid 5.8212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.0716402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.0716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.6016804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 11.6019148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 11.6011473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D004938 Esophageal Neoplasms Zinc 2.8016543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8311564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4716456712
MESH:D005234 Fatty Liver Amiodarone 16.9914986274
MESH:D005234 Fatty Liver Clofibrate 16.9919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.9915345470
MESH:D005234 Fatty Liver pirinixic acid 16.9920131406 19236843
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5116534752 16611131 16002989 15751030 16513791
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7120067830
MESH:D005534 Foot Diseases Arsenic 5.316392382
MESH:D005756 Gastritis Zinc 4.5517241300
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7016452187
MESH:D005909 Glioblastoma Genistein 7.0216598420
MESH:D005909 Glioblastoma Manganese 7.0217043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006130 Growth Disorders Zinc 3.8117217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.6520558911
MESH:D006333 Heart Failure Zinc 6.6517162251
MESH:D006335 Heart Injuries Zinc 5.5217074742
MESH:D016481 Helicobacter Infections Zinc 4.3117241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3518665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 3.9816456712
MESH:D006527 Hepatolenticular Degeneration Zinc 4.4517276780
MESH:D006529 Hepatomegaly Amiodarone 13.0215265979
MESH:D006529 Hepatomegaly pirinixic acid 13.0218467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0216120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D019584 Hot Flashes Estradiol 3.5017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8018606429 16354765 15340226 16959395 8697196
MESH:D006937 Hypercholesterolemia Amiodarone 3.658137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.9720558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2417050553
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1912960047 14722030
MESH:D006973 Hypertension Arsenic 4.9116076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9118850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.3116093927
MESH:D007021 Hypospadias Diethylstilbestrol 10.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4416569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.8117991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.8118031379 8137927
MESH:D007246 Infertility Diethylstilbestrol 4.1215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.7412878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 5.5515189238
MESH:D007333 Insulin Resistance bisphenol A 11.4016393666
MESH:D007333 Insulin Resistance Estradiol 11.4016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4016306350
MESH:D007511 Ischemia Zinc 4.3916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1216580747
MESH:D007642 Keratosis Arsenic 4.7412749816 16930632
MESH:D007674 Kidney Diseases Cadmium 13.4116226777 16322080 16962696
MESH:D007674 Kidney Diseases Estradiol 13.4115618244
MESH:D007674 Kidney Diseases Mercury 13.4117934191
MESH:D007674 Kidney Diseases Zinc 13.4116960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.1516705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.1516762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 16.1515610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8217184923
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9019248655
MESH:D007938 Leukemia Genistein 2.9017468513 18980019
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.3917339181
MESH:D008064 Lipidoses Amiodarone 3.3415342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.3918606216 15288473 18615449 15716488 15158331 18458672 10677585 15316131 16489207 15075984 16343077 18295389 15465738 18032466 12175628 16126171 14739098 18395095 16097051 15095483 15362042 17355460 12085344 17050028 12557150 18263696 15288472 11481614 18416461 16098781 12891558 15474484 16511523 18380797 12679928 17127702 17292413 16248980 11682029 15334695 17629604 18031379 12531686 15078482 11172339
MESH:D008107 Liver Diseases Arsenic 4.2411134558
MESH:D008107 Liver Diseases Thioacetamide 4.2418374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Thioacetamide 4.1012479984 15633222 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.237678174
MESH:D008113 Liver Neoplasms Arsenic 13.2316368122
MESH:D008113 Liver Neoplasms Diethylstilbestrol 13.2316712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 13.2316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.036135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 9.031423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.0312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2318516814
MESH:D008175 Lung Neoplasms Arsenic 2.3419168569 17306315 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3015700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2716002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.1712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Zinc 9.1712773700
MESH:D020149 Manganese Poisoning Estradiol 12.1719453300
MESH:D020149 Manganese Poisoning Manganese 12.1719453300 16568477 16551646
MESH:D009069 Movement Disorders Manganese 4.7816551646
MESH:D009135 Muscular Diseases pirinixic acid 3.2716239165
MESH:D009181 Mycoses Amiodarone 4.6517974566 12754197
MESH:D009203 Myocardial Infarction Genistein 5.3317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3319151258
MESH:D017202 Myocardial Ischemia Arsenic 8.3615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.3612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.0916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.0917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.0916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.527678174 18551238
MESH:D009369 Neoplasms Diethylstilbestrol 4.6415313581
MESH:D009369 Neoplasms pirinixic acid 4.6417405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009410 Nerve Degeneration Manganese 4.0916551646
MESH:D009421 Nervous System Malformations bisphenol A 28.2411399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.2411399458
MESH:D009421 Nervous System Malformations Estradiol 28.2411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 28.2416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.2414600291
MESH:D009436 Neural Tube Defects Arsenic 3.3016620997
MESH:D009447 Neuroblastoma Topotecan 3.7215176712
MESH:D020078 Neurogenic Inflammation Arsenic 4.1517056641
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.709802331
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.1816049721
MESH:D010024 Osteoporosis Genistein 3.1019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8616169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7411985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.4917306315
MESH:D010051 Ovarian Neoplasms Estradiol 7.4919401270
MESH:D010051 Ovarian Neoplasms Genistein 7.4919005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010300 Parkinson Disease Manganese 5.6311181820
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.6316702228
MESH:D020734 Parkinsonian Disorders Manganese 4.2616140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 12.2615371236 16905509 6392382
MESH:D016491 Peripheral Vascular Diseases Cadmium 12.2615687053
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4316977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011225 Pre-Eclampsia Zinc 3.9917114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.8510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.8517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.8511222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8220887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.4016140617
MESH:D011471 Prostatic Neoplasms bisphenol A 2.4016740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.4017075824
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.4017136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.4016740699
MESH:D011471 Prostatic Neoplasms Genistein 2.4015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.4015721890
MESH:D011471 Prostatic Neoplasms Zinc 2.4012429649 16606632 16517595 16700911
MESH:D011507 Proteinuria Arsenic 3.7821343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 4.5410548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7612832656 11597910 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.2719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012162 Retinal Degeneration Zinc 3.9516584753
MESH:D012640 Seizures 2,4-dinitrotoluene 5.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.3218551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8418724381
MESH:D012871 Skin Diseases Arsenic 2.6817453740 17938729 15952646 18709164 17050553 16353154 17548696 16759981 19834688 16702368 6392382
MESH:D012878 Skin Neoplasms Arsenic 5.3217976673 17029826 15504454 16251483 19538983 17050553
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3216192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.8816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8816709447
MESH:D013272 Stomach Diseases Omeprazole 4.3718545984
MESH:D013276 Stomach Ulcer Amiodarone 6.8518087811
MESH:D013276 Stomach Ulcer Omeprazole 6.8511906479 18237397 10750652 16755016 15991576 17977527
MESH:D019966 Substance-Related Disorders bisphenol A 3.7416684133 16045194
MESH:D013610 Tachycardia Amiodarone 4.0511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9519225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Amiodarone 11.2219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2212697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.5015710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6218020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Zinc 4.1816543248
MESH:D016171 Torsades de Pointes Amiodarone 3.9417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.1516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.1516049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.1517306315 17976673 19322015 11144890 19429237 15987713 18640142
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.1516712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1710091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8216175088
MESH:D014591 Uterine Diseases bisphenol A 12.9814652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6916690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1916002989 16513791
MESH:D014652 Vascular Diseases Arsenic 4.4917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved