AutismKB 2.0

Annotation Detail for XYLT1


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Basic Information Top
Gene Symbol:XYLT1 ( PXYLT1,XT-I,XT1,XTI,XYLTI )
Gene Full Name: xylosyltransferase I
Band: 16p12.3
Quick LinksEntrez ID:64131; OMIM: 608124; Uniprot ID:XYLT1_HUMAN; ENSEMBL ID: ENSG00000103489; HGNC ID: 15516
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6564heparan sulfate biosynthesis
PWY-6569chondroitin sulfate biosynthesis
PWY-6571dermatan sulfate biosynthesis
PWY-6557glycoaminoglycan-protein linkage region biosynthesis
Pathway IDPathway Name
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
2156Pseudoxanthoma elasticum
2256Aortic aneurysm
Desease Name
diabetic nephropathy
RENAL
No data
Desease Name
Pseudoxanthoma elasticum, modifier of severity of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of XYLT1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of XYLT1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of XYLT1 mRNAaffects expression 20382639
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6816485898 12540782 16109766 11743745 14986274 19416960 19164858 18713872 17562736 14550746 16227642 16781746 12594235 11461765 19739265 14725611 16081117 12153990 10915739 11529661 10774834 11739529 11287661 12705907 16393943 16177239 12392966 17522070 15968718 19085960 15619225 12958197 17906064 19420014 11834606 10663392 11421492 2444490 19923254 19370779 18071297
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D008107 Liver Diseases Acetaminophen 1.7119014921 16611625 19460945 12969438 11587558 19784758 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D011561 Pseudoxanthoma Elasticum marker/mechanism
MESH:D014581 Urticaria Acetaminophen 3.5010982225
Pathway ID Pathway Name
KEGG:00532 Glycosaminoglycan biosynthesis - chondroitin sulfate
KEGG:00534 Glycosaminoglycan biosynthesis - heparan sulfate
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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