AutismKB 2.0

Annotation Detail for ZFYVE20


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Basic Information Top
Gene Symbol:ZFYVE20 ( FLJ34993,MGC126210,Rabenosyn-5 )
Gene Full Name: zinc finger, FYVE domain containing 20
Band: 3p25.1
Quick LinksEntrez ID:64145; OMIM: 609511; Uniprot ID:RBNS5_HUMAN; ENSEMBL ID: ENSG00000131381; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
No data
No data
No data
Pathway IDPathway Name
500461Toll Like Receptor 9 (TLR9) Cascade
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ZFYVE20 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in increased expression of ZFYVE20 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.676135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.6712371664
MESH:D002779 Cholestasis Cyclosporine 3.2819486331
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.7818551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0721346803 18551238
MESH:D005234 Fatty Liver Cyclosporine 3.4019224547
MESH:D005355 Fibrosis Cyclosporine 3.9012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 5.118708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.3115720958
MESH:D006973 Hypertension Cyclosporine 2.2410903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.5115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5810903974 18776723 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.7516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.7512371664
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.297678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.822876784 2876786 6135515
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.8616801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.757678174 18551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.5117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7519348381 18481113
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.9416049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.6912371664
MESH:D011565 Psoriasis Cyclosporine 2.3516882103
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8518551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.2010091137
MESH:D014605 Uveitis Cyclosporine 5.051336536
MESH:D014985 Xerophthalmia Cyclosporine 5.5117120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134959491
    • No data
    Releated disease ID Related disease Name
    PA446847Arrhythmogenic Right Ventricular Dysplasia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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