AutismKB 2.0

Annotation Detail for NECAB1


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Basic Information Top
Gene Symbol:NECAB1 ( EFCBP1,STIP-1 )
Gene Full Name: N-terminal EF-hand calcium binding protein 1
Band: 8q21.3
Quick LinksEntrez ID:64168; OMIM: NA; Uniprot ID:NECA1_HUMAN; ENSEMBL ID: ENSG00000123119; HGNC ID: 20983
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NECAB1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NECAB1 mRNAdecreases expression 20382639
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NECAB1 mRNAaffects cotreatment|decreases expression 18606552
D005419 Flavonoids Flavonoids results in decreased expression of NECAB1 mRNAdecreases expression 18035473
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NECAB1 mRNAaffects cotreatment|decreases expression 18606552
D010634 Phenobarbital Phenobarbital results in increased expression of NECAB1 mRNAincreases expression 19270015
D014635 Valproic Acid Valproic Acid results in increased expression of NECAB1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 18558336 17688650 18396377 19460635 18316065 18177632 18985861 17157402 17507914 16609825 18940202 19232924 20603192 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9420007298 6705139 17173139 20935162 1701930
MESH:D009202 Cardiomyopathies Zalcitabine 4.8810591146
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2319641884 1733752
MESH:D004362 Drug Toxicity Zalcitabine 5.057515130
MESH:D004421 Dystonia Phenobarbital 11.471851702
MESH:D004421 Dystonia Valproic Acid 11.471851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 12.023659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 12.0217275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 11.5011558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 11.503922381 16628512
MESH:D004827 Epilepsy Phenobarbital 7.0820417680
MESH:D004827 Epilepsy Valproic Acid 7.0820417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 9.706401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.707562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.537750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.537750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.843659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.843659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Valproic Acid 9.4114986274 19224547
MESH:D005234 Fatty Liver Zalcitabine 9.4118299183
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D015658 HIV Infections Zalcitabine 4.4617457083
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D007249 Inflammation Flavonoids 2.7717296493
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 2.3919812893 15975961 19073162 19482888 21047994 8742319
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.8618308698 17172636 2563599 1399818 6150874
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008223 Lymphoma Zalcitabine 4.839488045 11980663 18798262 17941976 8764131 8840982 9205081
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.469205081 8764131 9488045
MESH:D009437 Neuralgia Zalcitabine 6.7117292584
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 12.0518606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 12.0518606552
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D019310 Pseudolymphoma Phenobarbital 13.7112752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.7111422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Phenobarbital 6.6111442880 4039156 3137016 16876388
MESH:D012640 Seizures Valproic Acid 6.611511512 15475178 16876388 11738929 11044598 17978042 3137016 14763951
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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