AutismKB 2.0

Annotation Detail for CARD9


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Basic Information Top
Gene Symbol:CARD9 ( CANDF2,hCARD9 )
Gene Full Name: caspase recruitment domain family, member 9
Band: 9q34.3
Quick LinksEntrez ID:64170; OMIM: 607212; Uniprot ID:CARD9_HUMAN; ENSEMBL ID: ENSG00000187796; HGNC ID: 16391
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04621NOD-like receptor signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2094Ulcerative colitis
Desease Name
ulcerative colitis
IMMUNE
Desease Name
Ulcerative colitis
Desease Name
Candidiasis, familial chronic mucocutaneous, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of CARD9 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CARD9 mRNAaffects expression 16483693
C006632 arsenic trioxide [arsenic trioxide co-treated with bortezomib] results in increased expression of CARD9affects cotreatment|increases expression 20471514
C400082 bortezomib [arsenic trioxide co-treated with bortezomib] results in increased expression of CARD9affects cotreatment|increases expression 20471514
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2018218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.2019698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.7319483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.7316206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:C537979 Candidiasis familial chronic mucocutaneous, autosomal recessive marker/mechanism
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9816217749 15553829 14691202 15073043 11135700
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 4.0516052434
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.7218974383
MESH:D003093 Colitis, Ulcerative marker/mechanism 20228799
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4715265979 18218290
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver Amiodarone 9.4414986274
MESH:D005234 Fatty Liver arsenic trioxide 9.4415073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D006529 Hepatomegaly Amiodarone 4.3115265979
MESH:D006934 Hypercalcemia bortezomib 5.8818089816
MESH:D006937 Hypercholesterolemia Amiodarone 4.309751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 5.0817991464 18020914
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 11.5712560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 11.5718089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.6020471514 16467208 16968895 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 4.6020471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4617107899 15622746 15748426 17649720 16331271 12679006 15336539 16823087 12712474 17869043 16330433 11161223 12018890 17217047 17712046 19225113 19035177 16966277 15213294 19642359 16891316 11468182 16112521 19075265 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008064 Lipidoses Amiodarone 3.7917567588 15342952
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome Amiodarone 9.2415350150 17391786 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 9.2415213294
MESH:D008171 Lung Diseases Amiodarone 3.6212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.2018516814
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008223 Lymphoma bortezomib 4.8316098063
MESH:D016393 Lymphoma, B-Cell bortezomib 5.7816675587
MESH:D008527 Medulloblastoma bortezomib 4.3519213072
MESH:D009101 Multiple Myeloma arsenic trioxide 8.7315949261 19549372 14977855 19417148 11468182
MESH:D009101 Multiple Myeloma bortezomib 8.7319112201 19112817 19372569
MESH:D009181 Mycoses Amiodarone 5.6212754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9712490602 11597910 12832656
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.7218724381
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Amiodarone 3.7418087811
MESH:D013610 Tachycardia Amiodarone 4.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7019225199
MESH:D013959 Thyroid Diseases Amiodarone 5.4819731979
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D013971 Thyrotoxicosis Amiodarone 5.4219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 12.4611989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 12.4615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6011780464 20435036 12973940 12845720
Pathway ID Pathway Name
KEGG:04621 NOD-like receptor signaling pathway
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26077
    • No data
    Releated disease ID Related disease Name
    PA443598Candidiasis, Chronic Mucocutaneous
    PA443750Colitis, Ulcerative
    PA443815Crohn Disease
    PA446116Inflammatory Bowel Diseases
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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