AutismKB 2.0

Annotation Detail for DPEP2


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Basic Information Top
Gene Symbol:DPEP2 ( MBD2 )
Gene Full Name: dipeptidase 2
Band: 16q22.1
Quick LinksEntrez ID:64174; OMIM: 609925; Uniprot ID:DPEP2_HUMAN; ENSEMBL ID: ENSG00000167261; HGNC ID: 23028
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-375leukotriene biosynthesis
No data
Pathway IDPathway Name
Hormone biosynthesis
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DPEP2 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DPEP2 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DPEP2 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DPEP2 mRNAincreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7315322242 14514962 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.4511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001943 Breast Neoplasms Estradiol 1.9012948864 17289903 17018787 18497071 14630087 16675129 19861407 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.3516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.8016924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6016120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.6316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2616354765 15668235 8697196 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.8819279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9718230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.2811473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.5310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.7120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5510048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6515340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 6.1015709030
MESH:D019584 Hot Flashes Estradiol 4.8217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.128697196 15340226 16959395 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0612200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.2616627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D007674 Kidney Diseases Estradiol 2.8315618244
MESH:D007680 Kidney Neoplasms Estradiol 3.4115610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.8511807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.5519453300
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.6217289903
MESH:D009421 Nervous System Malformations Estradiol 11.8116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.8114600291
MESH:D010051 Ovarian Neoplasms Estradiol 2.3319401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 4.0811896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.4420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0116740699
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2316192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D013978 Tibial Fractures Estradiol 5.7619048282
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
Pathway ID Pathway Name
REACT:15314 Hormone biosynthesis
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134985997
    • No data
    No data
    Releated drug ID Related drug Name
    PA449780glutathione
    PA449789glycine
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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