AutismKB 2.0

Annotation Detail for BLMH


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Basic Information Top
Gene Symbol:BLMH ( BH,BMH )
Gene Full Name: bleomycin hydrolase
Band: 17q11.2
Quick LinksEntrez ID:642; OMIM: 602403; Uniprot ID:BLMH_HUMAN; ENSEMBL ID: ENSG00000108578; HGNC ID: 1059
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
2062Neurodegenerative disorder
Desease Name
CANCER
Neoplasms, Germ Cell and Embryonal
pulmonary fibrosis
Testicular Neoplasms
No data
Desease Name
Alzheimer disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BLMH mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BLMH mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BLMH mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BLMH mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BLMH mRNAdecreases expression 20382639
D001761 Bleomycin BLMH gene polymorphism affects the susceptibility to Bleomycinaffects response to substance 12082022
D016190 Carboplatin Carboplatin results in decreased expression of BLMH mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin results in decreased expression of BLMH mRNAdecreases expression 18172885
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BLMH mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of BLMH mRNAincreases expression 18301758
D014212 Tretinoin Tretinoin results in increased expression of BLMH mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D058186 Acute Kidney Injury Cisplatin 4.1317670903 15814532 12690470
MESH:D055371 Acute Lung Injury Bleomycin 9.9817118201
MESH:D055371 Acute Lung Injury pirinixic acid 9.9818653653
MESH:D000230 Adenocarcinoma Cisplatin 2.7917638652 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease marker/mechanism
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D000860 Anoxia Bleomycin 5.6415782499
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5516206674 16197459
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.1514601052
MESH:D001943 Breast Neoplasms Cisplatin 2.3718382427 19526202
MESH:D001943 Breast Neoplasms Tretinoin 2.3716443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.133084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 9.1317982673
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.131917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 6.3316685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 6.3316685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 8.046189445
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 8.0417066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.0416096774 16051514
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829142499 9224671 14991402 9211117 9664655 16925845 9125849 8800419 10589399 17551590
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4411421492 12540782 16177239 15619225 14725611 19739265 16781746 11743745 16109766 17906064 12705907 19923254 12958197 14550746 14986274 10663392 19085960 2444490 11834606 11529661 16227642 18713872 16081117 12153990 19416960 11739529 11461765 10915739 18071297 11287661 17522070 16393943 12392966 16485898 15968718 19164858 19420014 12594235 19370779 10774834 17562736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Cisplatin 3.9812649298 12231392 15033597 19839026
MESH:D004487 Edema Bleomycin 7.8017118201
MESH:D004487 Edema pirinixic acid 7.8012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7620426865
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7615464296 16785472 15173087 17638652 16481741
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 2.9319236843 20131406
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Cisplatin 8.2915102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2916096774
MESH:D034381 Hearing Loss Cisplatin 4.4519898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5615464296
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19772884 19176532
MESH:D006689 Hodgkin Disease Bleomycin 8.5018501091 17606976 15147373
MESH:D006689 Hodgkin Disease Cisplatin 8.5016170182 16200630
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D007249 Inflammation Bleomycin 3.8017118201
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4115464296
MESH:D007674 Kidney Diseases Acetaminophen 6.4312587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 6.4312649298 12231392 15190930 18289764 19839026
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8516705839
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0611231351
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8719285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2619035177 17301526 16891316 17368321 9834237 12679006 17649720 15748426 17294898 19225113 16823087 16766008 17361223 17506722 17712046 16935935 16140955 16788101 19642359 19075265 17339181 19029980 17217047 16331271 17107899
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 19460945 11587558 12969438 12587719 19014921 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.607678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.642876784 6135515 2876786
MESH:D008175 Lung Neoplasms Bleomycin 3.206189445
MESH:D008175 Lung Neoplasms Cisplatin 3.2011798837 17225452 6189445
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Bleomycin 7.6815577320
MESH:D008545 Melanoma Carboplatin 7.6812040289 11712820 16342250 16225601
MESH:D008545 Melanoma Cisplatin 7.6812883367 12393984 11135225 18505091 17023156 18176117 18332650 16809738 15577323 16432458 17761969 12374674 16248763
MESH:D008545 Melanoma Tretinoin 7.6816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008654 Mesothelioma Cisplatin 3.3017638057
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009369 Neoplasms Carboplatin 12.6118854779 17925555
MESH:D009369 Neoplasms Cisplatin 12.6116773208
MESH:D009369 Neoplasms pirinixic acid 12.6117405874
MESH:D009369 Neoplasms Tretinoin 12.6116594593 16946489
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7615464296
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009447 Neuroblastoma Cisplatin 3.538761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D017599 Neuroectodermal Tumors Carboplatin 12.6112837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 12.618761367
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010051 Ovarian Neoplasms Cisplatin 5.2019769630 17225452 6897625 15464296
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2016936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.6419003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6415976015
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.6117638057
MESH:D011014 Pneumonia Bleomycin 5.6416317386 17071938 18024389
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011654 Pulmonary Edema Bleomycin 5.5815808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.9217241526 16115399 18008008 16314464 11554783 12624602 17177178 15541506 17434272 18162602 12574379 21435439 15322207 14609568
MESH:D051437 Renal Insufficiency Cisplatin 4.6215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.6314601052
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6115464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.6618396642 17522103 15958060
MESH:D013274 Stomach Neoplasms Tretinoin 2.6617261132
MESH:D015173 Supratentorial Neoplasms Carboplatin 6.0512837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.8117225452 15464296
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7216049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.7215464296 17225452 12973940
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.1216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.1216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8215577323
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D014839 Vomiting Cisplatin 4.9811897121
MESH:D015431 Weight Loss Bleomycin 5.8812624602
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25370
    • No data
    Releated disease ID Related disease Name
    PA445828Testicular Neoplasms
    PA445355Pneumonia
    Releated drug ID Related drug Name
    PA448645bleomycin
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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