AutismKB 2.0

Annotation Detail for POPDC3


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Basic Information Top
Gene Symbol:POPDC3 ( MGC22671,POP3,RP11-99L11.2,bA355M14.1 )
Gene Full Name: popeye domain containing 3
Band: 6q21
Quick LinksEntrez ID:64208; OMIM: 605824; Uniprot ID:POPD3_HUMAN; ENSEMBL ID: ENSG00000132429; HGNC ID: 17649
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
height
menarche (age at onset)
DEVELOPMENTAL
REPRODUCTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of POPDC3 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of POPDC3 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of POPDC3 mRNAincreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of POPDC3 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Estradiol 2.1017289903 19861407 12948864 17261762 16675129 17018787 18497071 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4618566989
MESH:D002779 Cholestasis Cyclosporine 8.7419486331
MESH:D002779 Cholestasis pirinixic acid 8.7419176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.2211473722 19148513 18566989
MESH:D005234 Fatty Liver Cyclosporine 9.0119224547
MESH:D005234 Fatty Liver pirinixic acid 9.0120131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.7012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006529 Hepatomegaly pirinixic acid 3.5518467677 16221962 19772884 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007333 Insulin Resistance Estradiol 8.0116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 8.0116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.6218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.6215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 8.4415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9315890375 20007298 16377806
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7917203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.3617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 4.1616427766 11399458
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.3119401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.848532709
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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