AutismKB 2.0

Annotation Detail for SFPQ


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Basic Information Top
Gene Symbol:SFPQ ( POMP100,PSF )
Gene Full Name: splicing factor proline/glutamine-rich
Band: 1p34.3
Quick LinksEntrez ID:6421; OMIM: 605199; Uniprot ID:SFPQ_HUMAN; ENSEMBL ID: ENSG00000116560; HGNC ID: 10774
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1980Kidney cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SFPQ mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SFPQ mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SFPQ mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of SFPQ mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of SFPQ mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SFPQ mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of SFPQ mRNAdecreases expression 16835338
C006632 arsenic trioxide arsenic trioxide results in increased expression of SFPQ mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SFPQ mRNAincreases expression 19150397
C095105 bexarotene bexarotene results in decreased expression of SFPQ mRNAdecreases expression 16648578
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SFPQ mRNAaffects expression 17484886
D002330 Carmustine Carmustine results in decreased expression of SFPQ mRNAdecreases expression 15980968
D003474 Curcumin Curcumin results in increased expression of SFPQ mRNAincreases expression 17198877
D004958 Estradiol Estradiol results in increased expression of SFPQ mRNAincreases expression 16514628
D004958 Estradiol Estradiol affects the expression of SFPQ mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SFPQ mRNAincreases expression 17475347
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SFPQ mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFPQ mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant results in decreased expression of SFPQ mRNAdecreases expression 16514628
C006253 pirinixic acid pirinixic acid results in increased expression of SFPQ mRNAincreases expression 18445702
D011374 Progesterone Progesterone results in decreased expression of SFPQ mRNAdecreases expression 18037150
C045950 propiconazole propiconazole results in increased expression of SFPQ mRNAincreases expression 19363144
D020849 Raloxifene Raloxifene results in decreased expression of SFPQ mRNAdecreases expression 16514628
D013629 Tamoxifen Tamoxifen results in increased expression of SFPQ proteinincreases expression 17098229
D013629 Tamoxifen [Tretinoin co-treated with Tamoxifen] results in increased expression of SFPQ proteinaffects cotreatment|increases expression 17098229
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFPQ mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SFPQ mRNAdecreases expression 16922920
D014212 Tretinoin [Tretinoin co-treated with Tamoxifen] results in increased expression of SFPQ proteinaffects cotreatment|increases expression 17098229
D014212 Tretinoin Tretinoin results in increased expression of SFPQ proteinincreases expression 17098229
C032910 triadimefon triadimefon results in increased expression of SFPQ mRNAincreases expression 19363144
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.917525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7811798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.7811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D000419 Albuminuria Raloxifene 4.4317451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9117887948
MESH:D000505 Alopecia Tretinoin 3.4815955085
MESH:D000544 Alzheimer Disease Curcumin 4.3015590663
MESH:D000544 Alzheimer Disease Raloxifene 4.3015800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.8212569548 18414634 16835338 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.5916807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5916292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D050197 Atherosclerosis Arsenic 6.5712928151 19371607
MESH:D050197 Atherosclerosis Curcumin 6.5718704882
MESH:D001284 Atrophy fulvestrant 4.6811514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Curcumin 4.3219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.6616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.6619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 10.4015845082 15665606 15380490
MESH:D001930 Brain Injuries Raloxifene 10.4016580743
MESH:D002545 Brain Ischemia Curcumin 4.1616770732
MESH:D001932 Brain Neoplasms Carmustine 8.6816187019
MESH:D001932 Brain Neoplasms Curcumin 8.6817596214
MESH:D001943 Breast Neoplasms bexarotene 5.6716818667 16344269
MESH:D001943 Breast Neoplasms Curcumin 5.6716243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Estradiol 5.6719861407 12948864 17289903 16675129 17018787 18497071 14630087 17261762
MESH:D001943 Breast Neoplasms fulvestrant 5.6718984771
MESH:D001943 Breast Neoplasms Progesterone 5.6715562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 5.6717440819 16912660 17049068 15758505 17952589 17595753 17242785 16837676 17261762 17893378 15775269 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 5.6718629630 19410462 19487384 19084267 19142967 20390343 18351453 17261762 19066611 19115204 18855134 19288272 17440819 19011961 21152245 15565566 16818667 17893378 20065188 11161223 19244106 19189210 18984771 18815881 20859285 19221464 18821012 20544844 18997820 19189212 16202921 20135344 20005174 15668708 19103187 21138602 19155303 16273361 19200415 19289846 16873071 19059307 17242785 17049068 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 5.6716873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6115673190 16124888 16227642 16192424 15721981 18705752 10355542 16011737 15700767 16050911 16097048 3786805
MESH:D002277 Carcinoma Curcumin 7.8318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5015504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 19.3716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 19.3716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 19.373084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 19.3716507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 19.3715073043 16217749 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 19.3718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 19.3716924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 19.371917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.6516247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.6518414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.3515504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.3518462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 15.0518640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 15.0517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 15.0517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 7.1617938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 7.1615775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.1616973168 18022660
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 11.8014694615
MESH:D002386 Cataract Acetaminophen 11.8010977129
MESH:D002386 Cataract Tretinoin 11.8017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.496135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.4920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4216129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3216919318 17333356 16105132 15861022 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 7.3219176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.5015668235 8697196 15340226 12621046 16354765
MESH:D002972 Cleft Palate Tretinoin 9.509407595
MESH:D002972 Cleft Palate triadimefon 9.5016781842
MESH:D003072 Cognition Disorders Raloxifene 4.4515800139
MESH:D003092 Colitis Curcumin 9.0816782535 18200517 16804969
MESH:D003092 Colitis Tretinoin 9.0817035595
MESH:D003103 Coloboma Curcumin 4.3918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4819359593 16340194
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.7015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7014669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.7318497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.2910525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.2916925845 9125849 9142499 9664655 17551590 8800419 9224671 14991402 10589399 9211117
MESH:D019465 Craniofacial Abnormalities triadimefon 5.2916875885 15834900
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0217474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.2718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2717107852
MESH:D003928 Diabetic Nephropathies Curcumin 20.2418204486
MESH:D003928 Diabetic Nephropathies Estradiol 20.2419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 20.2415920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 20.2419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.5921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.5918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 14.5921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.5916081117 19739265 16393943 16781746 19420014 11421492 11743745 12958197 14986274 16227642 10663392 18071297 15968718 19416960 12153990 11461765 11739529 12705907 12594235 14725611 19085960 17522070 16177239 14550746 19164858 17906064 15619225 10915739 16109766 11834606 12392966 12540782 2444490 11287661 19923254 11529661 16485898 19370779 10774834 17562736 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.597120509 2869522 16227642 7179309 16177239 15027814 7440962 15998439 19085960 11566570 10915739 19336974 9327722 6623471 4309450 21278145 3786805 6884620 3732212 10092053 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.5920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8817351913
MESH:D004487 Edema pirinixic acid 10.5312083418
MESH:D004487 Edema Raloxifene 10.5315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.3718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.5612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.5617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 20.5615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.5619031437
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 16.9019148513
MESH:D016889 Endometrial Neoplasms Estradiol 16.9011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.9019155303 16202921 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 16.9016569247
MESH:D004715 Endometriosis Progesterone 8.4316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.439294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3112903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.4111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.419664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 34.5915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.5916239168 16045604 17595544 19224547 12795759 12631006 15959796 61145
MESH:D005234 Fatty Liver Curcumin 34.5919297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.5915345470
MESH:D005234 Fatty Liver pirinixic acid 34.5920131406 19236843
MESH:D005234 Fatty Liver Raloxifene 34.5917473493
MESH:D005234 Fatty Liver Tamoxifen 34.5919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.7718705752
MESH:D005355 Fibrosis Curcumin 19.7718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.7720067830
MESH:D005355 Fibrosis Tretinoin 19.7717994277
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5218462866
MESH:D005909 Glioblastoma Carmustine 11.4016187019
MESH:D005909 Glioblastoma Curcumin 11.4017596214
MESH:D005909 Glioblastoma Tretinoin 11.4017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.5118462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.249664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.4211110106
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 19.3719772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly propiconazole 19.3717178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.3715340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 19.3717178689 17178688
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8717701891
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8715340226 16959395 18606429 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.1716870215
MESH:D006930 Hyperalgesia Tretinoin 7.1716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Curcumin 3.9018704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006973 Hypertension Arsenic 8.3016076760 9931084 11953799
MESH:D006973 Hypertension Raloxifene 8.3017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2315869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5417937319
MESH:D007248 Infertility, Male fulvestrant 6.5411514358
MESH:D007249 Inflammation Curcumin 11.2518403477 16956363 17151092
MESH:D007249 Inflammation Progesterone 11.2515869954
MESH:D007249 Inflammation Tamoxifen 11.2519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2512200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1418200517 18596194
MESH:D007333 Insulin Resistance Estradiol 6.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6017994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0710783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 16.3516580747
MESH:D007569 Jaw Abnormalities Tretinoin 16.3517551590 15992940
MESH:D007569 Jaw Abnormalities triadimefon 16.3515834900 15992940
MESH:D007642 Keratosis Arsenic 4.8212749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 5.5615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.5615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.6016705839
MESH:D007680 Kidney Neoplasms Estradiol 16.6015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.6018625569
MESH:D007889 Leiomyoma Curcumin 10.6218555241
MESH:D007889 Leiomyoma Raloxifene 10.6216973256
MESH:D007938 Leukemia arsenic trioxide 10.0415070760
MESH:D007938 Leukemia Curcumin 10.0418462866
MESH:D007938 Leukemia Tretinoin 10.0417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.2412560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.2416106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7720471514 16968895 16467208 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7719850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 12.1417339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.1417869043 9834237 16966277 17217047 16112521 15748426 11468182 15336539 11161223 16331271 19225113 12679006 17649720 15622746 19075265 17712046 15213294 12018890 19035177 16330433 19642359 12712474 17107899 16891316 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.1417107899 16823087 16140955 16891316 16331271 16788101 17301526 17361223 19029980 12679006 17217047 17712046 15748426 17506722 16766008 9834237 19035177 17649720 19225113 17294898 19642359 19075265 17339181 17368321 16935935
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.1616882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.1616106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.199224671
MESH:D008064 Lipidoses Tamoxifen 3.0317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7116221502 17157831 17174718 21278145 11408273 17334410 16943688 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5918376398 15730626 13678700 16015684 12958196 20821823 16192424 12389079 17525996 18481824 18418968 18472094 12445421 18277467 18187930 11481614 16033810 18472332 18429990 14724832 12667390 15925388 18251166 12445418 12546737 14620537 17766677 18166357 18420326 12649538 15876570 15673190 18279442 17481882 18339082 15370692 12632512 16011737 16027843 15338365 12609069 14716833 17900296 16116963 18395914 17708605 15362042 15057751 15052691 15959796 18205269 14512876 18156304 15650968 17714472 17805973 17640975 12632514 15818738 12898905 15123356 12666154 16097048 14748882 17721639 18263696 12741479 18210741 18395095 15893842 12586293 17976157 17631135 17823541 10355542 17944888 18412020 16638106 15996030 16248980 17761835 17869086 16136751 17557913 17922224 18006644 17565644 18705752 18317297 14716496 18054572 17698563 15931870
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.5917355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 15.3119014921 12969438 19784758 11587558 19460945 16611625 12587719 16610002
MESH:D008107 Liver Diseases Arsenic 15.3111134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 15.3116246199 17285989 15830285 16964402 15720792
MESH:D008107 Liver Diseases Curcumin 15.3116956363
MESH:D008107 Liver Diseases propiconazole 15.3119363144
MESH:D008107 Liver Diseases triadimefon 15.3119363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 28.927678174
MESH:D008113 Liver Neoplasms Arsenic 28.9216368122
MESH:D008113 Liver Neoplasms arsenic trioxide 28.9214682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 28.9219294768
MESH:D008113 Liver Neoplasms pirinixic acid 28.9220007298 15890375 16377806
MESH:D008113 Liver Neoplasms propiconazole 28.9219028983
MESH:D008113 Liver Neoplasms Tamoxifen 28.9216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 28.9216984957
MESH:D008113 Liver Neoplasms triadimefon 28.9219028983
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.002876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.0020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.0015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental propiconazole 22.0017178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.0012151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 22.0017178689
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2215213294
MESH:D008175 Lung Neoplasms Arsenic 8.2817306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2819825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 8.2817849452
MESH:D008175 Lung Neoplasms Curcumin 8.2819359593 16243823 18462866
MESH:D008175 Lung Neoplasms Tamoxifen 8.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2811884234 19555203
MESH:D008223 Lymphoma Curcumin 3.4718462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5216173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9811161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.4019196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.4016891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.4011408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.4019196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7217453147
MESH:D008545 Melanoma Carmustine 7.0912393984
MESH:D008545 Melanoma Curcumin 7.0918462866 17885582
MESH:D008545 Melanoma Tamoxifen 7.0912393984 19393235
MESH:D008545 Melanoma Tretinoin 7.0916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008569 Memory Disorders Curcumin 3.9917263510
MESH:D008591 Meningomyelocele Tretinoin 4.2516940565
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3815863610
MESH:D009101 Multiple Myeloma arsenic trioxide 11.4919417148 14977855 11468182 15949261 19549372
MESH:D009101 Multiple Myeloma Curcumin 11.4919372569
MESH:D009101 Multiple Myeloma Raloxifene 11.4916497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Arsenic 8.5515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009232 Myxoma Raloxifene 5.3816343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.7718551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.7716624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.7718495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms pirinixic acid 4.6317405874
MESH:D009369 Neoplasms Tretinoin 4.6316946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 17.3219196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 17.3212497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 17.3219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009421 Nervous System Malformations Estradiol 15.3716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3714600291
MESH:D009421 Nervous System Malformations Tretinoin 15.379125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.4618462866
MESH:D009436 Neural Tube Defects Arsenic 11.5516620997
MESH:D009436 Neural Tube Defects arsenic trioxide 11.5510525206
MESH:D009436 Neural Tube Defects Tretinoin 11.559142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009765 Obesity Curcumin 4.4619297423
MESH:D009765 Obesity pirinixic acid 4.4620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.2812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.2816049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.2814694615
MESH:D010024 Osteoporosis Curcumin 7.0618719352
MESH:D010024 Osteoporosis Raloxifene 7.0617882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0715758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 18.1717306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 18.1712452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 18.1718462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 18.1719401270
MESH:D010051 Ovarian Neoplasms Progesterone 18.1717393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 18.1716936753
MESH:D010146 Pain Acetaminophen 6.1316870215
MESH:D010146 Pain Tretinoin 6.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.3215580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.3219401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.3215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8215371236 16905509 6392382
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8816140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Curcumin 1.8818226269 10851300 18769126 18156803 11398177 12497104 15129424
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8815731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011507 Proteinuria Arsenic 8.7421343184
MESH:D011507 Proteinuria Tretinoin 8.7416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011625 Pterygium Tretinoin 4.6216723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.3819168576
MESH:D011693 Purpura Raloxifene 5.3815770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8718379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9416283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012509 Sarcoma Curcumin 3.9718462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4818551238
MESH:D018805 Sepsis Curcumin 3.9318389075
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 2.7015952646 17453740 16702368 17938729 17050553 19834688 16353154 17548696 16759981 6392382 18709164
MESH:D012878 Skin Neoplasms Arsenic 9.0119538983 16251483 15504454 17029826 17976673 17050553
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.0116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.3016503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.3019457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4117261132
MESH:D013276 Stomach Ulcer Curcumin 3.3519188055 16631530
MESH:D020521 Stroke Raloxifene 3.6916837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.3719014326
MESH:D013964 Thyroid Neoplasms Tretinoin 11.3716026305 17045167
MESH:D013964 Thyroid Neoplasms triadimefon 11.3717178689
MESH:D013978 Tibial Fractures Estradiol 13.1419048282
MESH:D013978 Tibial Fractures Raloxifene 13.1419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7915213294
MESH:D014376 Tuberculosis Tretinoin 3.1216040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 23.1216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 23.1216049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 23.1219322015 19429237 17306315 18640142 15987713 11144890 17976673
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 23.1212973940 11780464 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms Curcumin 23.1218593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 23.1217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 23.1217572228 16712894 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 5.0918462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4110091137
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4416752155
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8916761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D009396 Wilms Tumor Tretinoin 3.8216287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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