AutismKB 2.0

Annotation Detail for MLST8


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Basic Information Top
Gene Symbol:MLST8 ( GBL,GbetaL,LST8,MGC111011,POP3,WAT1 )
Gene Full Name: MTOR associated protein, LST8 homolog (S. cerevisiae)
Band: 16p13.3
Quick LinksEntrez ID:64223; OMIM: 612190; Uniprot ID:LST8_HUMAN; ENSEMBL ID: ENSG00000167965; HGNC ID: 24825
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04150mTOR signaling pathway
Pathway IDPathway Name
Signalling by NGF
Signaling by Insulin receptor
Signaling in Immune system
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200080mTOR signaling pathway
200083CXCR4-mediated signaling events
200061LKB1 signaling events
200150CXCR3-mediated signaling events
200169Class I PI3K signaling events mediated by Akt
200113ErbB1 downstream signaling
No data
Pathway IDPathway Name
500865mTOR signalling
500921S6K1-mediated signalling
500965Release of eIF4E
500980mTORC1-mediated signalling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MLST8 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MLST8 mRNAaffects expression 16483693
D005419 Flavonoids Flavonoids results in increased expression of MLST8 mRNAincreases expression 18035473
D012643 Selenium Selenium results in increased expression of MLST8 mRNAincreases expression 19244175
D014635 Valproic Acid Valproic Acid results in decreased expression of MLST8 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.028875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3019490988
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000550 Amblyopia Valproic Acid 5.8517688650
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.8617497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8615238991 19232924 20603192 18177632 18316065 18985861 17507914 17688650 19460635 17157402 16609825 18558336 18396377 18940202 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.2320046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.618888407
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8120734317
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.7319739265 18713872 16109766 16485898 11421492 11461765 11834606 2444490 14986274 16781746 12705907 12540782 19420014 16393943 15968718 10663392 12958197 15619225 16177239 19416960 10915739 10774834 19085960 12392966 11287661 14550746 19164858 14725611 16081117 17562736 16227642 12594235 17906064 19370779 18071297 11739529 17522070 19923254 12153990 11743745 11529661
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7315131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.7319641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Valproic Acid 4.451851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.6417275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.533922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.916426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.787750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.603659116
MESH:D005234 Fatty Liver Valproic Acid 3.6719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.5016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.578888407 18558336
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006849 Hydrocephalus Valproic Acid 5.4117688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D007249 Inflammation Flavonoids 2.8017296493
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 12969438 19460945 19784758 11587558 12587719 16611625 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.8717228818
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D008881 Migraine Disorders Valproic Acid 3.4418765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.408888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3317596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.3416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.3720603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.1512752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9614763951 16876388 15475178 11738929 1511512 11044598 17978042 3137016
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0619490988
MESH:D013226 Status Epilepticus Valproic Acid 5.1512833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.8517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.063119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.138888407
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:04150 mTOR signaling pathway
REACT:498 Signaling by Insulin receptor
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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