AutismKB 2.0

Annotation Detail for MS4A6A


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Basic Information Top
Gene Symbol:MS4A6A ( 4SPAN3,4SPAN3.2,CD20L3,MGC131944,MGC22650,MS4A6,MST090,MSTP090 )
Gene Full Name: membrane-spanning 4-domains, subfamily A, member 6A
Band: 11q12.2
Quick LinksEntrez ID:64231; OMIM: 606548; Uniprot ID:M4A6A_HUMAN; ENSEMBL ID: ENSG00000110077; HGNC ID: 13375
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MS4A6A mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of MS4A6A mRNAincreases expression 20458559
D001194 Asbestos Asbestos affects the expression of MS4A6A mRNAaffects expression 17297452
D007501 Iron Iron deficiency results in decreased expression of MS4A6A mRNAdecreases expression 20368581
C029938 nickel sulfate nickel sulfate results in decreased expression of MS4A6A mRNAdecreases expression 16780908
D013654 Taurine Taurine results in decreased expression of MS4A6A mRNAdecreases expression 16579726
D014807 Vitamin D Vitamin D affects the expression of MS4A6A mRNAaffects expression 20368581
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 4.6111954676 12718980 19131640 16100012
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 6.0516640825
MESH:D000544 Alzheimer Disease Iron 3.0516640825 16563566
MESH:D000740 Anemia Iron 4.6316434484 16566752
MESH:D018798 Anemia, Iron-Deficiency Iron 4.9117375513 16569441 17163184 17162259 17147795
MESH:D000756 Anemia, Sideroblastic Iron 5.0916910769
MESH:D001145 Arrhythmias, Cardiac Iron 4.6316604332
MESH:D001260 Ataxia Telangiectasia Iron 5.8515336622
MESH:D050197 Atherosclerosis Asbestos 7.9118795166
MESH:D050197 Atherosclerosis Iron 7.9116640825 16632123
MESH:D001321 Autistic Disorder Iron 2.7717352947
MESH:D001424 Bacterial Infections Iron 5.5916640825
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.9516206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1316705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1316217749 14691202 15073043 15553829 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D009202 Cardiomyopathies Iron 4.2116640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5416604332
MESH:D003110 Colonic Neoplasms Iron 2.9316640825
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 4.0211298694 16823706 16780908
MESH:D003920 Diabetes Mellitus Iron 4.7016604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.1416506275
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.4516025228
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.6618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Taurine 4.669328219
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005234 Fatty Liver arsenic trioxide 9.1615073043
MESH:D005234 Fatty Liver Iron 9.1616640825
MESH:D005621 Friedreich Ataxia Iron 5.7916604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D006432 Hemochromatosis Iron 4.6816640825 17053826 16604332 17236123 17255318 16574947
MESH:D006486 Hemosiderosis Iron 5.6616604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.9116640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.3017182432
MESH:D006529 Hepatomegaly Iron 4.6716890145
MESH:D015658 HIV Infections Iron 3.8016597321
MESH:D007006 Hypogonadism Iron 4.5916640825
MESH:D007037 Hypothyroidism Iron 5.4416640825
MESH:D019189 Iron Metabolism Disorders Iron 5.3417163184
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.6520471514 17050201 16467208 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 4.6520368581
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3815336539 17712046 16112521 9834237 17107899 16891316 16330433 19035177 15622746 12679006 17217047 19642359 11468182 12712474 11161223 19075265 16331271 15213294 15748426 16823087 12018890 17649720 19225113 17869043 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D020961 Lewy Body Disease Iron 5.7916563566
MESH:D008103 Liver Cirrhosis Iron 3.8616640825
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.2715931870 15893842
MESH:D008108 Liver Diseases, Alcoholic Iron 5.3617207112 16737972
MESH:D008113 Liver Neoplasms arsenic trioxide 5.2614682389
MESH:D008113 Liver Neoplasms Iron 5.2616640825 20302851
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8920377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.9111798837 19825857
MESH:D008175 Lung Neoplasms Asbestos 3.9112111688
MESH:D008175 Lung Neoplasms Iron 3.9116640825
MESH:D008268 Macular Degeneration Iron 4.1116640825
MESH:D008654 Mesothelioma Asbestos 4.1716319530 18709470 16564556 18310086 16919927
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2911468182 19417148 19549372 15949261 14977855
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 6.1217086897
MESH:D009181 Mycoses Iron 5.9116640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D017202 Myocardial Ischemia Iron 4.6616604332
MESH:D015428 Myocardial Reperfusion Injury Iron 4.4816604332
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009404 Nephrotic Syndrome Iron 4.7617178036
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D019636 Neurodegenerative Diseases Iron 4.4817296847 16604332
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D010003 Osteoarthritis Iron 4.1216640825
MESH:D010024 Osteoporosis Iron 8.5716640825 16648989
MESH:D010024 Osteoporosis Vitamin D 8.5717882678
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4712452020 16624393 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010212 Papilloma Iron 4.8412065085
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D020447 Parasomnias Iron 6.4617352947
MESH:D010300 Parkinson Disease Iron 3.4016640825 16563566
MESH:D010900 Pituitary Diseases Iron 6.1216604332
MESH:D011041 Poisoning Iron 4.5916604332
MESH:D017119 Porphyria Cutanea Tarda Iron 5.3116640825
MESH:D011225 Pre-Eclampsia Iron 4.6316640825
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D011528 Protozoan Infections Iron 6.4616640825
MESH:D012148 Restless Legs Syndrome Iron 4.7516930377
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Iron 3.5812065085
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013398 Sudden Infant Death Iron 5.8516640825
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D014376 Tuberculosis Iron 4.2416597321
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3912845720 20435036 12973940 11780464
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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