AutismKB 2.0

Annotation Detail for PDLIM2


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Basic Information Top
Gene Symbol:PDLIM2 ( FLJ34715,MYSTIQUE,SLIM )
Gene Full Name: PDZ and LIM domain 2 (mystique)
Band: 8p21.3
Quick LinksEntrez ID:64236; OMIM: 609722; Uniprot ID:PDLI2_HUMAN; ENSEMBL ID: ENSG00000120913; HGNC ID: 13992
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDLIM2 mRNAaffects expression 21346803
C068073 Am 580 Am 580 results in decreased expression of PDLIM2 mRNAdecreases expression 16982809
D000638 Amiodarone Amiodarone results in increased expression of PDLIM2 mRNAincreases expression 19774075
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDLIM2 mRNAaffects expression 17484886
D003314 Corn Oil Corn Oil affects the expression of PDLIM2 mRNAaffects expression 16360708
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNAaffects cotreatment|increases expression 16963248
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PDLIM2 mRNAaffects expression 17555576
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNAaffects cotreatment|increases expression 16963248
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of PDLIM2 mRNAaffects cotreatment|increases expression 16963248
C011890 kojic acid kojic acid results in increased expression of PDLIM2 mRNAincreases expression 16595896
C533894 LG 100815 LG 100815 results in decreased expression of PDLIM2 mRNAdecreases expression 16951191
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of PDLIM2 mRNAdecreases expression 16951191
C089730 rosiglitazone rosiglitazone results in decreased expression of PDLIM2 mRNAdecreases expression 16982809
D013629 Tamoxifen Tamoxifen affects the expression of PDLIM2 mRNAaffects expression 17555576
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PDLIM2 mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in increased expression of PDLIM2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.217525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma daidzein 7.2511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2514692618
MESH:D000230 Adenocarcinoma Genistein 7.2511473722
MESH:D000544 Alzheimer Disease rosiglitazone 2.8519621015
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8018218290 20041841 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.9018651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.9019483382
MESH:D001943 Breast Neoplasms Genistein 2.2616873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tamoxifen 2.2617261762 19189210 16873071 18351453 19288272 15668708 19289846 19059307 20005174 18997820 19244106 20065188 15565566 19011961 20390343 16273361 19410462 19142967 20544844 19189212 16818667 16202921 20859285 19155303 17049068 20135344 19115204 18629630 19103187 19084267 19487384 17242785 18425577 18855134 19200415 11161223 19066611 18821012 21138602 17893378 18815881 19221464 18984771 17440819 21152245
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.9815700767 3786805 15721981 16050911 16227642 16124888 15673190 16011737 18705752 10355542 16192424 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.9816050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5916705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.5918788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.5916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5916924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6217572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8915710769 19225199
MESH:D002318 Cardiovascular Diseases daidzein 7.8016332659
MESH:D002318 Cardiovascular Diseases Genistein 7.8016332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1018974383
MESH:D002386 Cataract Am 580 8.1717460283
MESH:D002386 Cataract Trinitrotoluene 8.1715817613 14694615
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8816919318 17110522 15861022 17333356 16105132 11677210 17681005
MESH:D003092 Colitis Am 580 4.9717035595
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.4015095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2718551238
MESH:D003490 Cyanosis Trinitrotoluene 11.2718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.3017446233
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 7.4516647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.4516647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.4512642470
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.0615265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.062869522 3786805 9327722 3732212 15968718 19085960 17522070 16177239 16227642 7179309 4309450 6623471 10092053 7120509 21278145 7440962 6884620 19336974 10915739 15998439 15027814 11566570
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.0621346803 18551238
MESH:C538011 Eales disease Vitamin E 4.739068938
MESH:D004487 Edema rosiglitazone 3.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.9819031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.6116402032
MESH:D016889 Endometrial Neoplasms daidzein 12.6511473722
MESH:D016889 Endometrial Neoplasms Genistein 12.6511473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.6519155303 20544844 17893378 16202921
MESH:D007172 Erectile Dysfunction daidzein 5.0214972507
MESH:D005234 Fatty Liver Amiodarone 24.7414986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.7416239168 12631006 17595544 61145 16045604 19224547 12795759 15959796
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.7415345470
MESH:D005234 Fatty Liver rosiglitazone 24.7419196556
MESH:D005234 Fatty Liver Tamoxifen 24.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.4718705752
MESH:D005909 Glioblastoma Genistein 3.2616598420
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9916080930
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019110552 19900420
MESH:D006529 Hepatomegaly Amiodarone 9.0815265979
MESH:D006529 Hepatomegaly Trinitrotoluene 9.0815817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0014716179
MESH:D006930 Hyperalgesia rosiglitazone 3.9212083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.888137927 9751232
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.8411484837
MESH:D006973 Hypertension daidzein 3.6717169123
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.5318020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9017937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.9012150543
MESH:D007249 Inflammation rosiglitazone 5.3612083418
MESH:D007249 Inflammation Tamoxifen 5.3619457130
MESH:D007251 Influenza, Human Vitamin E 4.2416624496
MESH:D007333 Insulin Resistance rosiglitazone 3.8016306350
MESH:D007674 Kidney Diseases Vitamin E 2.8012488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.3916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3918625569
MESH:D007938 Leukemia Genistein 3.0217468513 18980019
MESH:D008064 Lipidoses Amiodarone 7.9217567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.9215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8121278145 11903743 17174718 16943688 16221502 11408273 17157831 17334410 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.7717766677 17823541 20821823 12546737 18166357 17805973 15931870 10355542 12609069 18205269 18481824 18054572 13678700 12632514 16116963 18251166 17631135 14716496 17869086 18429990 12958196 18376398 12445421 15338365 15959796 16248980 16192424 14512876 18187930 17721639 18339082 15818738 17640975 18210741 18156304 15925388 15362042 17714472 17976157 15673190 17481882 12741479 17944888 12586293 14748882 17761835 18395095 17698563 18317297 15996030 17900296 18006644 15052691 16027843 15057751 17708605 18705752 12898905 16136751 16015684 18263696 14620537 16011737 18279442 18420326 15730626 17922224 18472094 18418968 18277467 17565644 18395914 15893842 12666154 16033810 18412020 18472332 12389079 15650968 12445418 17525996 15370692 14724832 12649538 14716833 17557913 12667390 16097048 15123356 15876570 11481614 16638106 12632512
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.7717823541
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.7717347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.7718564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.7716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0817285989 15830285 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6916899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5819294768
MESH:D008113 Liver Neoplasms Tamoxifen 4.5816684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.2118544905
MESH:D008133 Long QT Syndrome Amiodarone 3.5815350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 7.5212587719
MESH:D008171 Lung Diseases Vitamin E 7.5216863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5118516814
MESH:D008175 Lung Neoplasms Tamoxifen 2.4918625569
MESH:D008175 Lung Neoplasms Vitamin E 2.4911062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.1114578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 10.1116827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.1114580682 11731420 19196722 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3817261469
MESH:D009181 Mycoses Amiodarone 4.9317974566 12754197
MESH:D009203 Myocardial Infarction Genistein 2.8617141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6617141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7518551238
MESH:D009336 Necrosis Trinitrotoluene 10.7518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319189210 19196722 19200415
MESH:D009421 Nervous System Malformations Genistein 4.0416427766
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2312819281 16049721
MESH:D009784 Occupational Diseases Trinitrotoluene 9.2312819281 14694615 17852074
MESH:D010024 Osteoporosis Genistein 3.2519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0916169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6019005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D011230 Precancerous Conditions Corn Oil 5.0514668109
MESH:D011471 Prostatic Neoplasms Genistein 2.6015378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6015067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8512832656 12490602 11597910
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2018551238
MESH:D012640 Seizures Trinitrotoluene 6.2018551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1018724381
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.2115817613
MESH:D013276 Stomach Ulcer Amiodarone 3.3218087811
MESH:D020521 Stroke Vitamin E 3.5216517955
MESH:D013610 Tachycardia Amiodarone 4.3011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2019225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Amiodarone 4.7919731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.8719584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.2117467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0416049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.048653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3310091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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