AutismKB 2.0

Annotation Detail for SRSF3


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Basic Information Top
Gene Symbol:SRSF3 ( SFRS3,SRp20 )
Gene Full Name: serine/arginine-rich splicing factor 3
Band: 6p21.31-p21.2
Quick LinksEntrez ID:6428; OMIM: 603364; Uniprot ID:SRSF3_HUMAN; ENSEMBL ID: ENSG00000112081; HGNC ID: 10785
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
No data
No data
Pathway IDPathway Name
500866mRNA Splicing - Major Pathway
500570Cleavage of Growing Transcript in the Termination Region
500928Transport of Mature mRNA derived from an Intron-Containing Transcript
500105mRNA 3'-end processing
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SRSF3 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of SRSF3 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SRSF3 mRNAdecreases expression 15336504
C099555 CD 437 CD 437 results in decreased expression of SRSF3 mRNAdecreases expression 12958071
D003474 Curcumin Curcumin results in increased expression of SRSF3 mRNAincreases expression 17198877
D004958 Estradiol Estradiol affects the expression of SRSF3 mRNAaffects expression 15598610
C039614 ethylisopropylamiloride ethylisopropylamiloride results in increased expression of SRSF3 proteinincreases expression 17924536
C006253 pirinixic acid pirinixic acid results in increased expression of SRSF3 mRNAincreases expression 18301758
D018038 Sodium Selenite Sodium Selenite results in increased expression of SRSF3 mRNAincreases expression 18175754
D014212 Tretinoin Tretinoin results in decreased expression of SRSF3 mRNAdecreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3517887948
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease Curcumin 2.6515590663
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.8516807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.8516292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D050197 Atherosclerosis Curcumin 3.4118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.7119761891
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5516197459 16206674
MESH:D002545 Brain Ischemia Curcumin 4.5716770732
MESH:D001932 Brain Neoplasms Curcumin 4.1017596214
MESH:D001943 Breast Neoplasms Curcumin 1.9616243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Estradiol 1.9618497071 12948864 19861407 17018787 17261762 17289903 16675129 14630087
MESH:D001943 Breast Neoplasms Tretinoin 1.9616443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Curcumin 3.9718593918
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.661917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0318414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.9718462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9716096774 16051514
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Curcumin 10.3716804969 16782535 18200517
MESH:D003092 Colitis Tretinoin 10.3717035595
MESH:D003103 Coloboma Curcumin 4.7218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5319359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.1118497527
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.829142499 16925845 14991402 17551590 9125849 10589399 8800419 9224671 9664655 9211117
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7418403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.5518204486
MESH:D003928 Diabetic Nephropathies Estradiol 9.5519279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9816081117 11461765 19370779 11529661 12594235 16781746 12958197 19085960 16227642 17522070 17562736 17906064 19420014 16177239 11834606 12153990 12392966 12705907 16393943 19739265 10774834 11287661 16485898 18713872 19923254 14550746 10663392 18071297 15619225 11421492 16109766 19416960 2444490 11739529 19164858 10915739 14986274 15968718 11743745 12540782 14725611
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.9815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004381 Duodenal Ulcer Curcumin 4.2517351913
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.7711473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7716569247
MESH:D005124 Eye Abnormalities Tretinoin 3.7016938888 9664655
MESH:D005234 Fatty Liver Curcumin 8.4519297423
MESH:D005234 Fatty Liver pirinixic acid 8.4520131406 19236843
MESH:D005355 Fibrosis Curcumin 9.7318705752
MESH:D005355 Fibrosis Tretinoin 9.7317994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.9118462866
MESH:D005909 Glioblastoma Curcumin 7.6517596214
MESH:D005909 Glioblastoma Tretinoin 7.6517312396
MESH:D006258 Head and Neck Neoplasms Curcumin 8.2718829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2119772884 16221962 18467677 19176532
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2617701891
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.2218704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D007249 Inflammation Curcumin 6.3116956363 17151092 18403477
MESH:D007249 Inflammation ethylisopropylamiloride 6.3117237260
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2718200517 18596194
MESH:D007333 Insulin Resistance Estradiol 12.9516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.9516306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.9514714311
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.3810783313
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 6.1915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1215610895
MESH:D007889 Leiomyoma Curcumin 4.7618555241
MESH:D007938 Leukemia Curcumin 6.7518462866
MESH:D007938 Leukemia Tretinoin 6.7517143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3816106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8719285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617368321 17506722 17217047 19029980 16331271 17294898 16140955 19035177 9834237 17712046 15748426 17301526 16766008 17361223 17339181 16823087 16891316 19642359 17649720 19075265 17107899 19225113 16788101 12679006 16935935
MESH:D015458 Leukemia, T-Cell Curcumin 4.9616106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 5.1118705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1116248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.2211587558 16611625 19784758 12969438 19014921 12587719 19460945 16610002
MESH:D008107 Liver Diseases Curcumin 4.2216956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8716377806 15890375 20007298
MESH:D008175 Lung Neoplasms Curcumin 2.2716243823 19359593 18462866
MESH:D008223 Lymphoma Curcumin 3.7118462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2414737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.9116173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6617203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Curcumin 3.5618462866 17885582
MESH:D008545 Melanoma Tretinoin 3.5616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008569 Memory Disorders Curcumin 4.3517263510
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009101 Multiple Myeloma Curcumin 3.6319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1617962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5718495463
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009369 Neoplasms Tretinoin 5.1716946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.8012497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 10.3411399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.349125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.9018462866
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Curcumin 4.7319297423
MESH:D009765 Obesity pirinixic acid 4.7320558911
MESH:D010024 Osteoporosis Curcumin 3.5718719352
MESH:D010051 Ovarian Neoplasms CD 437 11.7517474084
MESH:D010051 Ovarian Neoplasms Curcumin 11.7518462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 11.7519401270
MESH:D010051 Ovarian Neoplasms Tretinoin 11.7516936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.6219401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6215976015
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Curcumin 2.6011398177 18226269 10851300 15129424 18769126 18156803 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6018760546
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.6919168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.2118379247 10666014
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012509 Sarcoma Curcumin 4.2818462866
MESH:D018805 Sepsis Curcumin 4.2218389075
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.048532709
MESH:D012878 Skin Neoplasms Tretinoin 6.0416467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013276 Stomach Ulcer Curcumin 3.6619188055 16631530
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.8416720286
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.8418593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.5018462866
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
REACT:78 Post-Elongation Processing of the Transcript
KEGG:03040 Spliceosome
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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