Annotation Detail for NSD1
Basic Information
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| Gene Symbol: | NSD1 ( ARA267,DKFZp666C163,FLJ10684,FLJ22263,FLJ44628,KMT3B,SOTOS,STO ) |
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| Gene Full Name: | nuclear receptor binding SET domain protein 1 |
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| Band: | 5q35.3 |
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| Quick Links | Entrez ID:64324; OMIM: 606681; Uniprot ID:NSD1_HUMAN; ENSEMBL ID: ENSG00000165671; HGNC ID: 14234 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa00310 | Lysine degradation |
| Desease ID | Desease Name |
|---|
| 1812 | Beckwith-Wiedemann syndrome |
| 2001 | Mental retardation |
| 2051 | Leukemia |
| 2124 | Autistic disorder |
| 2190 | Attention deficit hyperactivity disorder |
| Desease Name |
|---|
| congenital anomalies |
| DEVELOPMENTAL |
| Desease Name |
|---|
| Weaver syndrome |
| Leukemia, acute myeloid |
| Sotos syndrome |
| Beckwith-Wiedemann syndrome |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of NSD1 mRNA | affects expression | 17562736
|
| D000450 |
Aldosterone |
[Aldosterone binds to NR3C2 protein] which binds to NSD1 protein | affects binding | 15761029
|
| D017638 |
Asbestos, Crocidolite |
Asbestos, Crocidolite affects the expression of NSD1 mRNA | affects expression | 17331233
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NSD1 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| C017947 |
sodium arsenite |
sodium arsenite results in increased expression of NSD1 mRNA | increases expression | 16014739
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.52 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.02 | 16434500 |
| MESH:D000310 |
Adrenal Gland Neoplasms |
|
sodium arsenite |
5.31 | 15276417 |
| MESH:D018246 |
Adrenocortical Adenoma |
|
sodium arsenite |
5.51 | 17306315 16712894 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.45 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
marker/mechanism |
|
| 18001468 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D001506 |
Beckwith-Wiedemann Syndrome |
marker/mechanism |
|
| |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.52 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
3.03 | 3084413 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
sodium arsenite |
3.03 | 16507464 17306315 15276417 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
sodium arsenite |
2.46 | 18572023 |
| MESH:D002318 |
Cardiovascular Diseases |
|
Aldosterone |
4.96 | 11230374 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.77 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
sodium arsenite |
3.22 | 20056578 19524636 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.08 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.56 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
1.66 | 19923254 19416960 17562736 16109766 14550746 14725611 2444490 10915739 10774834 11739529 16227642 16781746 14986274 11529661 11834606 12705907 12540782 17906064 19164858 11461765 12594235 16177239 12153990 16081117 18713872 15968718 16393943 12958197 12392966 11743745 15619225 18071297 10663392 19739265 16485898 17522070 19370779 19085960 19420014 11287661 11421492 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.71 | 19426721 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.85 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.14 | 19236843 20131406 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.29 | 16983495 |
| MESH:D005833 |
Genital Neoplasms, Female |
|
sodium arsenite |
5.22 | 16452187 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.73 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.48 | 19176532 16221962 18467677 19772884 |
| MESH:D006689 |
Hodgkin Disease |
|
sodium arsenite |
3.47 | 12676792 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.99 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.53 | 20558911 |
| MESH:D007248 |
Infertility, Male |
|
sodium arsenite |
3.21 | 15346721 12646999 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.85 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
6.58 | 15629191 12587719 |
| MESH:D007674 |
Kidney Diseases |
|
sodium arsenite |
6.58 | 20008137 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
marker/mechanism |
|
| |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.69 | 11587558 19784758 12587719 19460945 16610002 19014921 16611625 12969438 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.58 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.85 | 16377806 20007298 15890375 |
| MESH:D008113 |
Liver Neoplasms |
|
sodium arsenite |
4.85 | 16712894 15276417 |
| MESH:D008171 |
Lung Diseases |
|
sodium arsenite |
3.40 | 19095001 |
| MESH:D055370 |
Lung Injury |
|
Asbestos, Crocidolite |
4.50 | 17365036 |
| MESH:D008175 |
Lung Neoplasms |
|
sodium arsenite |
1.90 | 17306315 19931552 17077188 15276417 16712894 |
| MESH:D008545 |
Melanoma |
|
sodium arsenite |
2.07 | 19082730 16487513 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.05 | 19513568 |
| MESH:D008607 |
Mental Retardation |
marker/mechanism |
|
| 12807965 |
| MESH:D008654 |
Mesothelioma |
|
Asbestos, Crocidolite |
3.30 | 18303189 16166281 16966607 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.99 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.26 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.22 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.45 | 17405874 |
| MESH:D009369 |
Neoplasms |
|
sodium arsenite |
5.45 | 11559025 |
| MESH:D009374 |
Neoplasms, Experimental |
|
sodium arsenite |
4.15 | 20056578 |
| MESH:D009436 |
Neural Tube Defects |
|
sodium arsenite |
3.36 | 12854658 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.18 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D010051 |
Ovarian Neoplasms |
|
sodium arsenite |
2.52 | 15276417 17306315 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.69 | 16870215 |
| MESH:D010995 |
Pleural Diseases |
|
Asbestos, Crocidolite |
5.38 | 10923243 |
| MESH:D011471 |
Prostatic Neoplasms |
|
sodium arsenite |
3.24 | 16039940 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Asbestos, Crocidolite |
3.14 | 17365031 15814490 17975199 17322281 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.53 | 19058328 |
| MESH:D012878 |
Skin Neoplasms |
|
sodium arsenite |
2.84 | 19524636 18572023 |
| MESH:D058495 |
Sotos Syndrome |
marker/mechanism |
|
| 12807965 14517949 15452385 14571271 15580547 15640245 16188863 18505455 20101679 16232326 18001468 17561922 |
| MESH:D016135 |
Spinal Dysraphism |
|
sodium arsenite |
4.07 | 12854658 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
sodium arsenite |
2.62 | 11723127 16712894 16452187 17306315 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.38 | 10982225 |
| MESH:D002583 |
Uterine Cervical Neoplasms |
|
sodium arsenite |
4.11 | 11813266 |
| MESH:D014652 |
Vascular Diseases |
|
sodium arsenite |
4.96 | 17056641 |
| MESH:C536687 |
Weaver syndrome |
marker/mechanism |
|
| 12807965 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:00310 |
Lysine degradation |
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