AutismKB 2.0

Annotation Detail for NFKBIZ


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Basic Information Top
Gene Symbol:NFKBIZ ( FLJ30225,FLJ34463,IKBZ,INAP,MAIL )
Gene Full Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Band: 3q12.3
Quick LinksEntrez ID:64332; OMIM: 608004; Uniprot ID:IKBZ_HUMAN; ENSEMBL ID: ENSG00000144802; HGNC ID: 29805
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NFKBIZ mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of NFKBIZ mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of NFKBIZ mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NFKBIZ mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NFKBIZ mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NFKBIZ mRNAincreases expression 20382639
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NFKBIZ mRNAaffects expression 17484886
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of NFKBIZ mRNA]affects reaction|decreases expression 17585979
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of NFKBIZ mRNAincreases expression 15331540
D016572 Cyclosporine Cyclosporine results in decreased expression of NFKBIZ mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of NFKBIZ mRNAdecreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of NFKBIZ mRNAincreases expression 15289156
D002117 Calcitriol Calcitriol results in decreased expression of NFKBIZ mRNAdecreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of NFKBIZ mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NFKBIZ mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NFKBIZ mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFKBIZ mRNAaffects cotreatment|increases expression 17942748
D005480 Flurbiprofen Flurbiprofen results in increased expression of NFKBIZ mRNAincreases expression 16949054
D019833 Genistein Genistein results in increased expression of NFKBIZ mRNAincreases expression 15289156
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of NFKBIZ mRNAincreases expression 20713471
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of NFKBIZ mRNAincreases expression 16809437
C041786 palm oil palm oil results in decreased expression of NFKBIZ mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NFKBIZ mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of NFKBIZ mRNAdecreases expression 17426115
D013629 Tamoxifen Tamoxifen affects the expression of NFKBIZ mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFKBIZ mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NFKBIZ mRNAincreases expression 17942748
19933214
18691609
D014415 Tunicamycin Tunicamycin results in increased expression of NFKBIZ mRNAincreases expression 17127020
D002762 Cholecalciferol Cholecalciferol results in increased expression of NFKBIZ mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6815322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.7911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7914692618
MESH:D000230 Adenocarcinoma Genistein 9.7911473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.546695378
MESH:D000236 Adenoma Methylcholanthrene 6.546695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.9110680582
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6520041841 18218290 18057881
MESH:D001161 Arteriosclerosis Cyclophosphamide 16.0815014928
MESH:D001161 Arteriosclerosis Dietary Fats 16.0815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 16.0811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3511922910
MESH:D001281 Atrial Fibrillation Amiodarone 3.7818651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.8616142846
MESH:D001778 Blood Coagulation Disorders Amiodarone 20.7019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 20.7019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.7019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.7012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8520146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 6.8511237771
MESH:D001943 Breast Neoplasms Cyclophosphamide 6.8517020986 11325840 15136595 18323546 12006526 17388661 16978400 18234424 15093573
MESH:D001943 Breast Neoplasms Dietary Fats 6.8520435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.8515324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 6.8517261762 14630087 17289903 19861407 17018787 12948864 18497071 16675129
MESH:D001943 Breast Neoplasms Genistein 6.8516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 6.8517474063
MESH:D001943 Breast Neoplasms Tamoxifen 6.8519189212 16202921 19103187 19011961 19189210 19244106 17261762 18855134 21152245 19221464 17440819 18997820 19200415 20135344 17049068 18821012 20859285 18351453 19288272 19066611 16873071 17893378 19487384 18815881 19410462 11161223 20390343 16818667 15565566 15668708 20005174 19084267 16273361 19142967 19059307 20065188 18984771 19155303 21138602 18629630 17242785 18425577 19115204 20544844 19289846
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6110355542 15700767 16097048 15673190 16192424 15721981 16124888 16227642 3786805 18705752 16011737 16050911
MESH:D002277 Carcinoma Methylcholanthrene 7.8810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.6618788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 13.6619701751
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.6616924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.6616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.6616924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6616924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7216152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.4616201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.5211237771
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8315710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 3.1916332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9118974383
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.8620889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 19.861399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.8612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.8618566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 19.8616192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 12.6119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6116105132 17110522 17681005 15861022 16919318 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 12.6119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 15668235 16354765 8697196 15340226
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3916002989 12952375
MESH:D003556 Cystitis Cyclophosphamide 4.8118710439 16413132 18093676 17979934 17010015 11948286 18433785 18483878 12913760 10700343 15643279 16989017 16651033 12161096 10498854 18295254 15276878 18372110 12388444 16614059
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9310990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1718772604
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1917107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.532444490 16227642 19370779 16177239 14550746 11421492 11743745 19164858 11739529 19085960 12153990 15968718 10774834 12594235 17562736 12958197 15619225 14986274 12392966 17906064 10663392 11834606 12540782 16109766 11529661 19420014 10915739 19739265 19923254 17522070 12705907 11461765 16485898 14725611 11287661 19416960 16393943 16081117 18071297 16781746 18713872
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.5315265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.5315027814 15998439 17522070 7440962 10915739 3786805 4309450 3732212 9327722 7120509 2869522 6884620 21278145 19336974 15968718 10092053 7179309 16177239 16227642 6623471 11566570 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D050171 Dyslipidemias Clofibrate 8.4116707586
MESH:D050171 Dyslipidemias Dietary Fats 8.4118367378
MESH:D004487 Edema pirinixic acid 6.0312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.3815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.3812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.3216402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.3216402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.8816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 16.8811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 16.8811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.8817893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.879294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 4.0511006010
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Amiodarone 40.6814986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 40.6817595544 12631006 16045604 15959796 19224547 12795759 61145 16239168
MESH:D005234 Fatty Liver Clofibrate 40.6819224547
MESH:D005234 Fatty Liver Cyclosporine 40.6819224547
MESH:D005234 Fatty Liver Dietary Fats 40.6817967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.6815345470
MESH:D005234 Fatty Liver pirinixic acid 40.6820131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 40.6814986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.8716002989 16611131 15751030 16534752 16513791
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.8716709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7710962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 19.7318705752
MESH:D005355 Fibrosis Cyclosporine 19.7312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.7318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.7320067830
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7716452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Genistein 3.1516598420
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3411389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8616376943 11014644 15172196
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1511294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.1211918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3614986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319110552 19900420
MESH:D006529 Hepatomegaly Amiodarone 13.4315265979
MESH:D006529 Hepatomegaly pirinixic acid 13.4316221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.4315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.6417606976 16135485
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.659751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.6521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2712960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.7310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.6716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6716569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.3418020914 17991464
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1616076520
MESH:D007246 Infertility Diethylstilbestrol 4.1915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Cyclophosphamide 6.507193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5017937319
MESH:D007249 Inflammation Dietary Fats 11.2820412841
MESH:D007249 Inflammation Flurbiprofen 11.2811099482
MESH:D007249 Inflammation Tamoxifen 11.2819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2812200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.6511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.6516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.6516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.4118776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.4115618244
MESH:D007680 Kidney Neoplasms Cyclosporine 16.6112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.6115003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 16.6115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 16.6118625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8917184923
MESH:D007938 Leukemia Cyclophosphamide 6.4010602166
MESH:D007938 Leukemia Genistein 6.4018980019 17468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4318587576 17658394 17008537 17802794 17296974 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9610373061
MESH:D007970 Leukopenia Cyclophosphamide 4.7911830472 10052129
MESH:D008064 Lipidoses Amiodarone 7.5117567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.5115342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3217174718 11903743 17157831 16943688 16239168 17334410 11408273 21278145 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4517565644 14716496 16097048 17761835 16011737 12632514 18472094 12666154 15650968 17721639 17481882 18279442 18263696 16248980 15893842 18205269 14748882 18210741 14724832 15370692 18420326 18054572 18156304 18251166 12609069 18339082 17976157 14512876 15052691 17708605 12649538 15730626 18472332 12389079 17869086 15338365 11481614 15362042 20821823 10355542 16136751 18412020 17525996 12546737 18395095 18376398 17766677 18429990 12667390 12445418 12741479 15818738 18418968 14620537 16033810 15123356 18481824 18006644 18187930 17823541 18166357 15673190 17900296 18395914 15876570 17922224 17631135 15931870 12586293 15925388 16192424 17557913 12632512 16015684 13678700 17805973 18317297 16638106 15959796 16027843 17944888 17714472 12445421 17698563 12958196 12898905 17640975 15996030 18705752 15057751 16116963 18277467 14716833
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.4518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4512878042
MESH:D008107 Liver Diseases Acetaminophen 3.7512969438 12587719 19014921 16610002 19784758 16611625 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7517285989 15830285 16964402 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.1320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.1319294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 17.1316712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 17.1315890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 17.1316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.1316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.2612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.26598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2612151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4511989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 3.2612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3118516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.6818520028 17053015 18816296 20135361 20464547 20064080 18569708 20869020 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.6816271038 11893704 20970405 21163286 16337739 9230183 1399818 17909032 15390079 6695378 20512841 7750092 10545420
MESH:D008175 Lung Neoplasms Tamoxifen 4.6818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6819555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9815166399
MESH:D008223 Lymphoma Cyclophosphamide 7.4812854902
MESH:D008223 Lymphoma Diethylstilbestrol 7.4815700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4416675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0311911406
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3416002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.3516891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.3514578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.3514580682 11731420 19196723 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0719453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.2619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.2616388313
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009181 Mycoses Amiodarone 4.7317974566 12754197
MESH:D009203 Myocardial Infarction Genistein 5.4417141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.4116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.4117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.4116411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.1911141357
MESH:D009369 Neoplasms Cyclophosphamide 11.1918854779
MESH:D009369 Neoplasms Diethylstilbestrol 11.1915313581
MESH:D009369 Neoplasms pirinixic acid 11.1917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8319189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 22.0911399458
MESH:D009421 Nervous System Malformations Estradiol 22.0916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 22.0916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 22.0914600291
MESH:D009447 Neuroblastoma Cyclophosphamide 3.558761367 16115947 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.7212837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.168291058
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.779802331
MESH:D009765 Obesity Dietary Fats 4.2916723640 20132043 18457598 21332399 19632207 17217161 18674790 20518802 11836018
MESH:D009765 Obesity pirinixic acid 4.2920558911
MESH:D009845 Oligospermia Cyclophosphamide 4.5416517039
MESH:D010024 Osteoporosis Genistein 3.1519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9216169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.7219401270
MESH:D010051 Ovarian Neoplasms Genistein 4.7219005980
MESH:D010146 Pain Acetaminophen 6.3916870215
MESH:D010146 Pain Cyclophosphamide 6.3912161096 18093676
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.1211332152
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5015687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7121297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.9917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9911399792 11222880 11896295 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6115572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.9016289102 15754350 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.9017024972
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.9017136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.9015046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.9016740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.9017409433
MESH:D011471 Prostatic Neoplasms Genistein 2.9015256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.9015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.7611597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.7616636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6616636934
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9118724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.2110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2116192470
MESH:D013088 Spermatocele Diethylstilbestrol 19.1316002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 19.1316709447
MESH:D013088 Spermatocele Tamoxifen 19.1316709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3416517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.1718087811
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.8812837982
MESH:D013610 Tachycardia Amiodarone 4.1211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Amiodarone 11.4819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.4812697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.6918020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D016171 Torsades de Pointes Amiodarone 4.0211989578 17467628
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.4217053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.4214692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.4217306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.4217572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8816175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.9215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9214692618
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2716513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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