AutismKB 2.0

Annotation Detail for TRA2B


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Basic Information Top
Gene Symbol:TRA2B ( DKFZp686F18120,Htra2-beta,SFRS10,SRFS10,TRA2-BETA,TRAN2B )
Gene Full Name: transformer 2 beta homolog (Drosophila)
Band: 3q27.2
Quick LinksEntrez ID:6434; OMIM: 602719; Uniprot ID:TRA2B_HUMAN; ENSEMBL ID: ENSG00000136527; HGNC ID: 10781
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1821Spinal cord disease
Desease Name
Body mass index
weight
METABOLIC
Desease Name
Body mass index
Weight
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TRA2B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRA2B mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of TRA2B mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNAaffects expression|affects splicing 17673517
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRA2B proteinincreases expression 17673517
D004997 Ethinyl Estradiol [Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNAaffects expression|affects splicing 17673517
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TRA2B proteinincreases expression 17673517
D001556 Lindane Lindane affects the expression of TRA2B mRNAaffects expression 17785943
D009151 Mustard Gas Mustard Gas results in increased expression of TRA2B mRNAincreases expression 15674844
D018038 Sodium Selenite Sodium Selenite results in increased expression of TRA2B mRNAincreases expression 18175754
D014212 Tretinoin Tretinoin results in increased expression of TRA2B mRNAincreases expression 15563401
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000382 Agricultural Workers' Diseases Lindane 4.7012661182
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.6715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.6716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Mustard Gas 5.1910378619
MESH:D001249 Asthma Tretinoin 5.1916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516197459 16206674
MESH:D001943 Breast Neoplasms Lindane 2.5214688026
MESH:D001943 Breast Neoplasms Tretinoin 2.5216443354 16166294 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.961917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3717681005 17333356 16919318 15861022 16105132 17110522 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8314991402 16925845 9125849 10589399 9664655 9142499 8800419 9211117 9224671 17551590
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0318713872 19164858 10915739 11421492 16781746 15619225 11287661 16081117 18071297 16485898 17906064 16177239 14725611 11743745 12153990 19370779 19416960 10663392 11461765 17562736 19739265 11739529 12705907 16393943 11834606 16227642 12958197 19085960 19923254 11529661 17522070 16109766 12540782 19420014 15968718 14986274 14550746 12594235 10774834 12392966 2444490
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema Mustard Gas 3.559260866 11428631 11428647 11402378
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005124 Eye Abnormalities Tretinoin 3.7516938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 8.4019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4015345470
MESH:D005355 Fibrosis Cyclosporine 9.7312639820 12168785
MESH:D005355 Fibrosis Tretinoin 9.7317994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Mustard Gas 2.898975870 17524151 9260866 9357497 16001271 11428620 11428631 11428647 11402378
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1417551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3016823087 17368321 17294898 16331271 17649720 17217047 16891316 9834237 17301526 19642359 16935935 17712046 16788101 17339181 17361223 19029980 19075265 17506722 19225113 16766008 15748426 12679006 16140955 17107899 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.4419784758 16611625 12587719 12969438 11587558 19460945 16610002 19014921
MESH:D008107 Liver Diseases Lindane 4.441715830
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008171 Lung Diseases Mustard Gas 3.6018702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.173148597 8781369
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009369 Neoplasms Lindane 5.7812807735 16818664
MESH:D009369 Neoplasms Tretinoin 5.7816594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.209142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.2616870215
MESH:D010146 Pain Tretinoin 7.2616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Lindane 3.6114688026 12661182
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.6118760546
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011537 Pruritus Ethinyl Estradiol 10.6815861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.6818058305
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017894541 17620002 10334151 17266442 17720292
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616116481 16283617
MESH:D012640 Seizures Lindane 3.777539098 12842176 15475178
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:03040 Spliceosome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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