AutismKB 2.0

Annotation Detail for SFTPB


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Basic Information Top
Gene Symbol:SFTPB ( PSP-B,SFTB3,SFTP3,SMDP1,SP-B )
Gene Full Name: surfactant protein B
Band: 2p11.2
Quick LinksEntrez ID:6439; OMIM: 178640; Uniprot ID:PSPB_HUMAN; ENSEMBL ID: ENSG00000168878; HGNC ID: 10801
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00217Pulmonary surfactant metabolism dysfunction
Inherited disorders of ion transport and metabolism
Genetic disorders
Desease IDDesease Name
1761Respiratory tract disease
1804Chronic obstructive airway disease
1818Systemic scleroderma
1826Cystic fibrosis
1832Congenital abnormality
1962Respiratory distress syndrome
2077Sinusitis
2120Rabies
2168Cutaneous fibrous histiocytoma
2192Lung disease
Desease Name
Pulmonary Disease, Chronic Obstructive
pneumonia
CARDIOVASCULAR
CANCER
IMMUNE
sepsis
chronic obstructive pulmonary disease/COPD
lung cancer
INFECTION
acute respiratory distress syndrome
No data
Desease Name
Surfactant metabolism dysfunction, pulmonary, 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000255 Adenosine Triphosphate Adenosine Triphosphate results in increased secretion of SFTPB proteinincreases secretion 14565945
D000255 Adenosine Triphosphate Adenosine Triphosphate results in increased secretion of SFTPB proteinincreases secretion 11704537
D000255 Adenosine Triphosphate Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]decreases reaction|increases secretion 11704537
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SFTPB mRNAaffects expression 16483693
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 16490937
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 15083329
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 16863852
D001761 Bleomycin Bleomycin results in decreased expression of SFTPB mRNAdecreases expression 15782499
C086232 bosentan bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
C086232 bosentan bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
C086232 bosentan bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
D002857 Chromium SFTPB intron polymorphism affects the susceptibility to Chromiumaffects response to substance 16570259
D003907 Dexamethasone Dexamethasone results in increased expression of SFTPB mRNAincreases expression 2539393
16857225
D003907 Dexamethasone Thiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA]decreases reaction|increases expression 16857225
D003907 Dexamethasone Dexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]affects binding|decreases reaction 10830305
D003907 Dexamethasone Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 11051153
10830305
D003907 Dexamethasone Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 11051153
D003907 Dexamethasone Dexamethasone results in increased expression of SFTPB mRNAincreases expression 11792629
D002117 Calcitriol Calcitriol results in increased expression of SFTPB mRNAincreases expression 15951333
D002117 Calcitriol Calcitriol results in increased expression of SFTPB proteinincreases expression 15951333
D019830 Adenosine-5'-(N-ethylcarboxamide) Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB proteinincreases secretion 14565945
D019830 Adenosine-5'-(N-ethylcarboxamide) Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB proteinincreases secretion 11704537
D019830 Adenosine-5'-(N-ethylcarboxamide) Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]decreases reaction|increases secretion 11704537
D005419 Flavonoids Flavonoids results in increased expression of SFTPB mRNAincreases expression 18035473
D006854 Hydrocortisone Hydrocortisone results in increased expression of SFTPB mRNAincreases expression 2539393
D015759 Ionomycin Ionomycin results in increased secretion of SFTPB proteinincreases secretion 14565945
D015759 Ionomycin Ionomycin results in increased secretion of SFTPB proteinincreases secretion 11704537
D008345 Manganese Manganese results in increased expression of SFTPB mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of SFTPB mRNAincreases expression 17175027
D009532 Nickel Nickel results in decreased expression of SFTPB mRNAdecreases expression 16166738
D009532 Nickel SFTPB protein affects the reaction [Nickel results in decreased expression of MT1 mRNA]affects reaction|decreases expression 16166738
D009532 Nickel SFTPB protein affects the reaction [Nickel results in decreased expression of MT2 mRNA]affects reaction|decreases expression 16166738
C029938 nickel sulfate nickel sulfate affects the expression of SFTPB mRNAaffects expression 12718980
C029938 nickel sulfate nickel sulfate results in decreased expression of SFTPB mRNAdecreases expression 19131640
11893692
C029938 nickel sulfate nickel sulfate results in decreased expression of SFTPB proteindecreases expression 11954676
C029938 nickel sulfate SFTPB protein affects the susceptibility to nickel sulfateaffects response to substance 19131640
C029938 nickel sulfate TGFA protein inhibits the reaction [nickel sulfate results in decreased expression of SFTPB protein]decreases expression|decreases reaction 11954676
D009569 Nitric Oxide bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
D009569 Nitric Oxide Nitric Oxide results in decreased expression of SFTPB mRNAdecreases expression 15640287
D009569 Nitric Oxide PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
D020030 Nitric Oxide Donors bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
D020030 Nitric Oxide Donors Nitric Oxide Donors results in decreased expression of SFTPB mRNAdecreases expression 15640287
D020030 Nitric Oxide Donors PD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
C007350 nitrofen Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 16490937
C007350 nitrofen Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 15083329
C007350 nitrofen nitrofen results in decreased expression of SFTPB mRNAdecreases expression 16490937
C007350 nitrofen nitrofen results in decreased expression of SFTPB proteindecreases expression 16490937
15083329
C007350 nitrofen Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 16490937
C007350 nitrofen Vitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 16490937
C007350 nitrofen nitrofen results in decreased expression of SFTPB mRNAdecreases expression 12194114
C007350 nitrofen Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 16863852
C007350 nitrofen Dexamethasone inhibits the reaction [nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]]affects binding|decreases reaction 10830305
C007350 nitrofen Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 11051153
10830305
C007350 nitrofen Dexamethasone inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 11051153
C007350 nitrofen nitrofen inhibits the reaction [NKX2-1 protein binds to SFTPB promoter]affects binding|decreases reaction 10830305
C007350 nitrofen nitrofen results in decreased expression of SFTPB mRNAdecreases expression 11588001
10830305
11076806
11057544
11051153
C007350 nitrofen nitrofen results in decreased expression of SFTPB proteindecreases expression 11051153
16863852
C007350 nitrofen nitrofen results in increased expression of SFTPB proteinincreases expression 17245593
C007350 nitrofen NKX2-1 protein affects the reaction [nitrofen results in decreased expression of SFTPB protein]affects reaction|decreases expression 10830305
C007350 nitrofen Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 11588001
C007350 nitrofen Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 16863852
C007350 nitrofen Vitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 16863852
D026423 S-Nitroso-N-Acetylpenicillamine bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
D026423 S-Nitroso-N-Acetylpenicillamine PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNAdecreases expression 15640287
D010100 Oxygen Oxygen affects the expression of SFTPB mRNAaffects expression 9555576
D010269 Paraquat Paraquat results in increased expression of SFTPB proteinincreases expression 17174135
D010269 Paraquat Paraquat results in decreased expression of SFTPB mRNAdecreases expression 17215068
C093321 PD 156707 PD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
C093321 PD 156707 PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
C093321 PD 156707 PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 15640287
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPB protein]decreases reaction|increases secretion 11704537
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPB protein]decreases reaction|increases secretion 11704537
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein]decreases reaction|increases secretion 11704537
D013726 Terbutaline Terbutaline results in increased expression of SFTPB mRNAincreases expression 2539393
D013726 Terbutaline ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPB protein]increases reaction|increases secretion 14565945
D013726 Terbutaline Terbutaline results in increased secretion of SFTPB proteinincreases secretion 14565945
D013726 Terbutaline Terbutaline results in increased secretion of SFTPB proteinincreases secretion 11704537
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SFTPB mRNAincreases expression 18990726
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased secretion of SFTPB proteinincreases secretion 14565945
D013755 Tetradecanoylphorbol Acetate Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPB protein]decreases reaction|increases secretion 11704537
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased secretion of SFTPB proteinincreases secretion 11704537
D013893 Thiram Thiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA]decreases reaction|increases expression 16857225
D014212 Tretinoin Tretinoin results in increased expression of SFTPB mRNAincreases expression 18435480
D014544 Uridine Triphosphate Uridine Triphosphate results in increased secretion of SFTPB proteinincreases secretion 14565945
C025643 vinclozolin vinclozolin affects the expression of SFTPB mRNAaffects expression 19015723
D014801 Vitamin A Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 16490937
D014801 Vitamin A Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 11588001
D014801 Vitamin A Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 16863852
D014810 Vitamin E Vitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB mRNA]decreases expression|decreases reaction 16490937
D014810 Vitamin E Vitamin E inhibits the reaction [nitrofen results in decreased expression of SFTPB protein]decreases expression|decreases reaction 16863852
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 7.7614610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7615322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.5710992263
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D055371 Acute Lung Injury Bleomycin 19.4717118201
MESH:D055371 Acute Lung Injury Nickel 19.4716166738
MESH:D055371 Acute Lung Injury nickel sulfate 19.4711954676 16100012 19131640 12718980
MESH:D055371 Acute Lung Injury Oxygen 19.4716759491
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0516835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4411874814
MESH:D000505 Alopecia Tretinoin 3.3615955085
MESH:D000544 Alzheimer Disease Nitric Oxide 3.2417556102
MESH:D000686 Amyloidosis Terbutaline 5.327986221
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.0511748828
MESH:D000740 Anemia Vitamin A 8.0516960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5216960172
MESH:D000756 Anemia, Sideroblastic Manganese 10.0616910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.0616910769
MESH:D000860 Anoxia Bleomycin 10.5715782499
MESH:D000860 Anoxia Oxygen 10.5720872349
MESH:D001008 Anxiety Disorders vinclozolin 3.3919015723
MESH:D001169 Arthritis, Experimental Dexamethasone 6.8617659584
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 4.8616456186
MESH:D001249 Asthma Vitamin A 4.8616732791
MESH:D050197 Atherosclerosis Oxygen 3.6116391483
MESH:D001321 Autistic Disorder Terbutaline 3.4717400887 16417856
MESH:D001471 Barrett Esophagus Tretinoin 4.0916935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.9716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 4.4516443354
MESH:D001943 Breast Neoplasms Calcitriol 4.4511237771
MESH:D001943 Breast Neoplasms Chromium 4.4515986119
MESH:D001943 Breast Neoplasms Nickel 4.4515986119
MESH:D001943 Breast Neoplasms Nitric Oxide 4.4515631943
MESH:D001943 Breast Neoplasms Oxygen 4.4517263869
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4520435547
MESH:D001943 Breast Neoplasms Tretinoin 4.4516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 11.9316813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 11.9317377406 17426644
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.5311713377 9428835
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8316168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.861917145
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 10.066189445
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.0611237771
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 10.0618922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.0616096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1916120746 18670907 18850075
MESH:D002386 Cataract Adenosine Triphosphate 7.3315003327
MESH:D002386 Cataract Tretinoin 7.3317460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2616129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1416153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Nitric Oxide 8.0716919318
MESH:D002779 Cholestasis Vitamin A 8.0716175620
MESH:D002822 Choriocarcinoma Tretinoin 4.8316461808
MESH:D002972 Cleft Palate Hydrocortisone 13.0215826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 13.0212621046 16354765 15340226 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 13.029407595
MESH:D002972 Cleft Palate Vitamin A 13.0216054864
MESH:D003092 Colitis Tretinoin 3.3917035595
MESH:D003110 Colonic Neoplasms Dexamethasone 4.0015824018
MESH:D003110 Colonic Neoplasms Vitamin A 4.0016267017 17219422
MESH:D003139 Common Cold Ascorbic Acid 5.1417323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D003371 Cough Terbutaline 5.2319679606
MESH:D003384 Coxsackievirus Infections bosentan 6.2720392896
MESH:D019465 Craniofacial Abnormalities Dexamethasone 11.1817728286
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 11.1817728286
MESH:D019465 Craniofacial Abnormalities nitrofen 11.1811405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 11.1810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 11.189211117 16925845 9664655 17551590 8800419 10589399 9125849 14991402 9142499 9224671
MESH:D019465 Craniofacial Abnormalities Vitamin A 11.1810992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 11.1819769572
MESH:D003456 Cryptorchidism vinclozolin 4.0314966744
MESH:D015140 Dementia, Vascular Nitric Oxide 5.6317556102
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 10.0112438553
MESH:D017449 Dermatitis, Allergic Contact Nickel 10.0119470301 17100760 17244072
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 10.0111298694 16823706 16780908
MESH:D003877 Dermatitis, Contact Nickel 4.342952479
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4116506275
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.2616506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003967 Diarrhea Dexamethasone 7.597237001
MESH:D003967 Diarrhea Hydrocortisone 7.597237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.4816146918
MESH:D004417 Dyspnea Oxygen 4.5020016425
MESH:C538011 Eales disease Ascorbic Acid 20.649068938
MESH:C538011 Eales disease Vitamin A 20.649068938
MESH:C538011 Eales disease Vitamin E 20.649068938
MESH:D004480 Ectromelia Vitamin A 5.4916054864
MESH:D004485 Eczema Dexamethasone 4.1512438553
MESH:D004487 Edema Bleomycin 14.1817118201
MESH:D004487 Edema Dexamethasone 14.1819703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.1812711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 14.1815177302 7812673 16716910 9599246 8273558 8113982 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8418230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.6315138306
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7410568697 9294722
MESH:D004892 Erythema Multiforme Thiram 6.3216750123
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0416938888 9664655
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005327 Fetal Resorption Vitamin A 5.0316054864
MESH:D005355 Fibrosis Terbutaline 13.1315467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.1320067830
MESH:D005355 Fibrosis Tretinoin 13.1317994277
MESH:D005739 Gas Poisoning Oxygen 4.8920016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6116973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9716417039
MESH:D005909 Glioblastoma Manganese 6.7517043766
MESH:D005909 Glioblastoma Tretinoin 6.7517312396
MESH:D005911 Gliosis Paraquat 4.8311124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006261 Headache Nitric Oxide 4.8511554966 11284996
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8316084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 24.0516080930
MESH:D006330 Heart Defects, Congenital nitrofen 24.0516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 24.0511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 24.0514991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 24.0510992263 16080930
MESH:D006330 Heart Defects, Congenital Vitamin E 24.0516080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5815340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 16863852 10830305
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 16.7316863852 16490937
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 16.737520565
MESH:D006548 Hernia, Diaphragmatic nitrofen 16.7312407540 17245593 18958481 10370017 10646786 9476886 11329586 18280291 12021965 11076806 15185205 10359170 16490937 16473863 12759764 12746050 10898224 9575882 8863223 15756563 9859898 17618886 12505043 17270546 12194112 16720372 7760232 11051153 7576705 15764645 10693666 10541330 11057544 15793718 9698600 12547725 10370016 11588001 16292651 15088113 12904592 11685700 15136996 15707848 11409163 18280292 16863852 9473106 15578192 10898222 11584395 16080930 7520565
MESH:D006548 Hernia, Diaphragmatic Vitamin A 16.7316877224 15707848 17436238 16490937 16292552 16863852
MESH:D006548 Hernia, Diaphragmatic Vitamin E 16.7316490937 16863852
MESH:D015658 HIV Infections Nickel 6.6317263646
MESH:D015658 HIV Infections Vitamin A 6.6316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.2717209195
MESH:D006689 Hodgkin Disease Bleomycin 4.1118501091 17606976 15147373
MESH:D019584 Hot Flashes Vitamin E 3.6414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Tretinoin 2.9616870215
MESH:D006940 Hyperemia Nitric Oxide 5.2911156591
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2516778211
MESH:D006973 Hypertension Dexamethasone 4.8217042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8218850075 18670907
MESH:D006976 Hypertension, Pulmonary bosentan 8.3416219361
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 8.3415838368
MESH:D006985 Hyperventilation Terbutaline 5.7510895896
MESH:D006986 Hypervitaminosis A Vitamin A 5.8416054864
MESH:D007008 Hypokalemia Terbutaline 5.7717292646
MESH:D007246 Infertility Thiram 5.536420938
MESH:D007248 Infertility, Male Paraquat 6.224850670
MESH:D007248 Infertility, Male vinclozolin 6.2216467254
MESH:D007249 Inflammation Bleomycin 17.7417118201
MESH:D007249 Inflammation Dexamethasone 17.7411099482 8960868
MESH:D007249 Inflammation Flavonoids 17.7417296493
MESH:D007249 Inflammation Nickel 17.7416166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.7412878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 17.7411698051 15177302 7562506 8273558 7812673
MESH:D007251 Influenza, Human Vitamin E 3.8816624496
MESH:D007410 Intestinal Diseases Nitric Oxide 9.0511574821 10210152 11713966
MESH:D007410 Intestinal Diseases Tretinoin 9.0517994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.4915955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.9717551590 15992940
MESH:D007674 Kidney Diseases Chromium 5.9717934191
MESH:D007674 Kidney Diseases Vitamin E 5.9712488133
MESH:D007896 Leishmaniasis Nitric Oxide 4.3817218153
MESH:D053609 Lethargy Terbutaline 5.9810895896
MESH:D007938 Leukemia Tretinoin 2.6117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0219850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9419642359 16331271 17294898 17339181 17649720 15748426 19035177 17217047 12679006 16766008 16891316 17107899 16935935 17712046 16823087 17368321 9834237 16140955 17361223 17506722 19075265 19225113 17301526 19029980 16788101
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4116417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.739224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.7316054864
MESH:D008103 Liver Cirrhosis Vitamin A 3.7016256175
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.2816718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.2818397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.2816248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.2816169303
MESH:D008107 Liver Diseases Vitamin A 3.0716175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.8416762690
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.6016984957
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 8.8818544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.8812151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 8.8817113696
MESH:D008171 Lung Diseases marker/mechanism 16863852
MESH:D008171 Lung Diseases Ascorbic Acid 15.9416863852
MESH:D008171 Lung Diseases nitrofen 15.9417245593 16863852 9614859 9859898
MESH:D008171 Lung Diseases Vitamin A 15.9416863852
MESH:D008171 Lung Diseases Vitamin E 15.9416863852
MESH:D055370 Lung Injury Nitric Oxide 8.6911395602
MESH:D055370 Lung Injury Oxygen 8.6918339021
MESH:D008175 Lung Neoplasms marker/mechanism 16570259
MESH:D008175 Lung Neoplasms Ascorbic Acid 7.9916401635
MESH:D008175 Lung Neoplasms Bleomycin 7.996189445
MESH:D008175 Lung Neoplasms Dexamethasone 7.9911195469 15824018
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9911884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.9911807781
MESH:D008175 Lung Neoplasms Vitamin E 7.9911062179
MESH:D008223 Lymphoma Nitric Oxide 4.0516166326
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.168985016
MESH:D020149 Manganese Poisoning Manganese 5.1916551646 16568477 19453300
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma Bleomycin 3.5915577320
MESH:D008545 Melanoma Tretinoin 3.5916752155
MESH:D008591 Meningomyelocele Tretinoin 4.1116940565
MESH:D008881 Migraine Disorders Nitric Oxide 4.0511701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.8011304026 14659530
MESH:D009069 Movement Disorders Manganese 4.7116551646
MESH:D009101 Multiple Myeloma Dexamethasone 7.0215867202 15744524 16118317
MESH:D009101 Multiple Myeloma Vitamin A 7.0216374440
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.919809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D009369 Neoplasms Tretinoin 2.2616594593 16946489
MESH:D009410 Nerve Degeneration Manganese 7.9716551646
MESH:D009410 Nerve Degeneration Paraquat 7.9716893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.489125849
MESH:D009436 Neural Tube Defects Tretinoin 6.949142499
MESH:D009436 Neural Tube Defects Vitamin A 6.9417400914
MESH:D009765 Obesity Ascorbic Acid 3.0617217161
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.7814998686
MESH:D010009 Osteochondrodysplasias Thiram 5.2815899490 15518828 17954590
MESH:D010051 Ovarian Neoplasms Tretinoin 2.2416936753
MESH:D010146 Pain Tretinoin 2.6516870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.1015976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1015976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9818404319 8330346 18922899 12065085
MESH:D010300 Parkinson Disease Manganese 5.3011181820
MESH:D010300 Parkinson Disease Paraquat 5.3011445065 11124998 12911755 16140633 11181820 16510128 15451049 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1116190885
MESH:D020734 Parkinsonian Disorders Manganese 4.1916140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D011014 Pneumonia Bleomycin 10.3517071938 16317386 18024389
MESH:D011014 Pneumonia Paraquat 10.3512504350
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.0118573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4011399792 11222880 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.4018042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.6118220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4515572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.9712479363 18247401 15754350 16289102 16644109
MESH:D011471 Prostatic Neoplasms Thiram 2.9719789329
MESH:D011471 Prostatic Neoplasms Vitamin E 2.9715084515
MESH:D011472 Prostatitis vinclozolin 4.6118629315
MESH:D011507 Proteinuria Tretinoin 3.3116636307
MESH:D011625 Pterygium Tretinoin 4.4716723453
MESH:D011654 Pulmonary Edema Bleomycin 10.4415808516
MESH:D011654 Pulmonary Edema Terbutaline 10.4410903255
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0014606601
MESH:D011658 Pulmonary Fibrosis Bleomycin 5.7811554783 18162602 16314464 21435439 17177178 17434272 17241526 12624602 15322207 12574379 16115399 18008008 14609568 15541506
MESH:D011658 Pulmonary Fibrosis Paraquat 5.7817997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 19.2211700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 19.2217627322 18339021
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 19.2211700416
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 19.222878809
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.4816877224
MESH:D012135 Respiratory Sounds Paraquat 3.7411874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration Paraquat 3.6316458197
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8016116481 16283617
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.139673227
MESH:D012772 Shock, Septic Terbutaline 5.173431524
MESH:D012871 Skin Diseases Ascorbic Acid 7.6218709164
MESH:D012871 Skin Diseases Vitamin A 7.6218709164
MESH:D012871 Skin Diseases Vitamin E 7.6218709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5916192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.598330346 12065085 18404319 11807781 8985016
MESH:D012878 Skin Neoplasms Tretinoin 8.5916467112
MESH:D013272 Stomach Diseases Dexamethasone 4.0015472012
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 10.6618726076
MESH:D013276 Stomach Ulcer Dexamethasone 10.6615138204
MESH:D013276 Stomach Ulcer Nitric Oxide 10.6615138204
MESH:D020521 Stroke Ascorbic Acid 8.0416517955 16403987
MESH:D020521 Stroke Vitamin E 8.0416517955
MESH:D013398 Sudden Infant Death Oxygen 5.2212563064
OMIM:265120 SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 1 marker/mechanism
MESH:D013610 Tachycardia Terbutaline 5.1910895896
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5116051514
MESH:D014376 Tuberculosis Tretinoin 3.0316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2816752155
MESH:D014605 Uveitis Dexamethasone 4.491336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020301 Vasospasm, Intracranial Nitric Oxide Donors 5.8219057314
MESH:D014802 Vitamin A Deficiency Vitamin A 4.9816175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.7516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015431 Weight Loss Bleomycin 5.3212624602
MESH:D009396 Wilms Tumor Tretinoin 3.6916287080
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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