AutismKB 2.0

Annotation Detail for ZMAT3


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Basic Information Top
Gene Symbol:ZMAT3 ( FLJ12296,FLJ31683,MGC10613,PAG608,WIG-1,WIG1 )
Gene Full Name: zinc finger, matrin-type 3
Band: 3q26.32
Quick LinksEntrez ID:64393; OMIM: 606452; Uniprot ID:ZMAT3_HUMAN; ENSEMBL ID: ENSG00000172667; HGNC ID: 29983
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
No data
Pathway IDPathway Name
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in increased expression of ZMAT3 mRNAincreases expression 17070881
C035314 1-nitropropane 1-nitropropane results in decreased expression of ZMAT3 mRNAdecreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of ZMAT3 mRNAincreases expression 17070881
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ZMAT3 mRNAaffects expression 21346803
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in increased expression of ZMAT3 mRNAincreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in decreased expression of ZMAT3 mRNAdecreases expression 17070881
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of ZMAT3 mRNAincreases expression 14600272
15890375
C016617 2-nitropropane 2-nitropropane results in increased expression of ZMAT3 mRNAincreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of ZMAT3 mRNAdecreases expression 17070881
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ZMAT3 mRNAincreases expression 15890375
14600272
D000082 Acetaminophen Acetaminophen affects the expression of ZMAT3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ZMAT3 proteinaffects expression 20106945
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of ZMAT3 mRNAincreases expression 15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ZMAT3 mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of ZMAT3 mRNAincreases expression 12928149
15122651
15120971
15935812
15342939
D001554 Benzene TRP53 protein affects the reaction [Benzene results in increased expression of ZMAT3 mRNA]affects reaction|increases expression 12928149
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZMAT3 mRNAdecreases expression 20018196
C053541 bicalutamide bicalutamide results in increased expression of ZMAT3 mRNAincreases expression 15638997
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ZMAT3 mRNAdecreases expression 16644059
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ZMAT3 mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of ZMAT3 mRNAincreases expression 14600272
15890375
D004317 Doxorubicin Doxorubicin results in increased expression of ZMAT3 mRNAincreases expression 16439685
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ZMAT3 mRNAincreases expression 15212814
D005419 Flavonoids Flavonoids results in increased expression of ZMAT3 mRNAincreases expression 18035473
C024352 fludarabine fludarabine results in increased expression of ZMAT3 mRNAincreases expression 16439685
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of ZMAT3 mRNAincreases expression 17317680
D015073 2-Acetylaminofluorene TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of ZMAT3 mRNA]affects expression|affects reaction 17317680
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of ZMAT3 mRNAincreases expression 17070881
D005472 Fluorouracil Fluorouracil results in increased expression of ZMAT3 mRNAincreases expression 17982676
D005472 Fluorouracil TP53 protein promotes the reaction [Fluorouracil results in increased expression of ZMAT3 mRNA]increases expression|increases reaction 17982676
D008701 Methapyrilene Methapyrilene results in increased expression of ZMAT3 mRNAincreases expression 15890375
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ZMAT3 mRNAincreases expression 17616710
C482205 nutlin 3 nutlin 3 results in increased expression of ZMAT3 mRNAincreases expression 16439685
C482205 nutlin 3 nutlin 3 results in increased expression of ZMAT3 proteinincreases expression 16439685
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of ZMAT3 mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in increased expression of ZMAT3 mRNAincreases expression 15890375
C010327 salinomycin salinomycin results in decreased expression of ZMAT3 mRNAdecreases expression 19682730
C402769 tipifarnib tipifarnib results in increased expression of ZMAT3 mRNAincreases expression 16403772
D014415 Tunicamycin Tunicamycin results in decreased expression of ZMAT3 mRNAdecreases expression 17127020
D014635 Valproic Acid Valproic Acid results in increased expression of ZMAT3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.158875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6219490988
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8118653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.4416033868
MESH:D000230 Adenocarcinoma Doxorubicin 9.4417418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.4414692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.4417638652
MESH:D000236 Adenoma 2-Acetylaminofluorene 10.3610737359
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.3616176798
MESH:D000236 Adenoma Dimethylnitrosamine 10.3619555203
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.666705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.1416434500
MESH:D000419 Albuminuria Doxorubicin 4.2221441931
MESH:D000550 Amblyopia Valproic Acid 4.8917688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1615469931
MESH:D000740 Anemia Fluorouracil 3.4216511603 15504547 17963324
MESH:D000741 Anemia, Aplastic Benzene 4.1114761424 17661222 11369114
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3117497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 15238991 17688650 18177632 18775368 18940202 17507914 19232924 17157402 16609825 18558336 20603192 18985861 19460635 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 2.9020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8519483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.188888407
MESH:D001855 Bone Marrow Diseases Benzene 4.8816183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3514601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.5217150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.5311921183
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 3.5320146248
MESH:D001943 Breast Neoplasms Benzene 3.5311921183 17162533
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.5317129689 15324884
MESH:D001943 Breast Neoplasms Doxorubicin 3.5317369602 18382427 16264153 15692762 17983394 16826403 18628466 15567936 16115903 15634643 18234424 16935488 15668708 17426702 19526202 15136595 15939500 15994142 16595493 16322301 18695136 15993339 16096432 11325840
MESH:D001943 Breast Neoplasms Fluorouracil 3.5316595493 16110121 15136595 18357371 16557594 19217205 18608205
MESH:D001943 Breast Neoplasms salinomycin 3.5319682730
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4516011737 10355542 16097048 15700767 16227642 16124888 16192424 3786805 16050911 15673190 15721981 18705752
MESH:D002276 Carcinoid Tumor Doxorubicin 11.2016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.2016051944
MESH:D002277 Carcinoma Dimethylnitrosamine 7.7519555203
MESH:D002277 Carcinoma Fluorouracil 7.7517121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 15.833084413 10737359 3581430 17761372 6705139
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.833084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 15.8321507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.8318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 15.8316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 15.8316234567 17876044 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.8317088986 16332177 17971768 16799960 18930000 17045692
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.1316201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.1318695887
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.0616033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.066189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.0618986760 16280240 16757204 17066447
MESH:D009202 Cardiomyopathies Doxorubicin 3.3117329180 17382496 16364871 16269455 17131338 17924179 17928571 16651473 17308081 16242529 16455267 15476868 17974986 16612575 15505089 15811867 17007740 16952015 16278810 16731534 17351982 16109756 17519947 15792986 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8317334414 16243910
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.5020889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9117110522 17333356 15861022 17681005 11677210 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 6.9119176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.1817725105 16510598 18772588 15001691 17172411 16340194 17018589 17169374 17016597 17287894
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.5618259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5618383874 16331619 17016601 16524972 15148649 16391804 17094418 16303861 17401013 18288408 17255274 20501625 15289873 18448328 17594712 17454858 14970324 18802399 18949393 18509181 16282729 17695437
MESH:D019465 Craniofacial Abnormalities Benzene 2.8015643154
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.808888407 16575769 17688650
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2316002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6818551238
MESH:D007644 Darier Disease Fluorouracil 4.4516733453
MESH:D003872 Dermatitis Benzene 4.4315902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 16.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 16.9915804453 20517888 16445897
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.9910774834 16393943 11834606 2444490 11421492 19164858 15968718 14725611 16227642 12392966 19420014 19923254 19085960 16081117 12958197 11529661 16177239 11461765 17522070 18713872 14986274 11743745 15619225 16109766 10663392 16485898 19739265 17562736 16781746 19370779 12705907 11739529 18071297 19416960 17906064 10915739 14550746 11287661 12594235 12540782 12153990
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 16.9910092053 7179309 10915739 9327722 21278145 6884620 15027814 3786805 2869522 17522070 4309450 11566570 15968718 3732212 7440962 16177239 19085960 6623471 19336974 7120509 16227642 15998439
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 16.998172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.9917416283
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 16.991733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Doxorubicin 3.4218602426
MESH:D004421 Dystonia Valproic Acid 3.741851702
MESH:D004487 Edema pirinixic acid 2.1912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.8712538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.9816804899 15700306
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.9817359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8118037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.823659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5716628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.7620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.316254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.967750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.723659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6620426865
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.6617016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.6616481741 15173087 16337965 16785472 17638652
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.6615623463 16805852 15547733 15878914 16510608 15264214 15150132 15547721 16704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.2712795759 16239168 61145 15959796 19224547 17595544 12631006 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.2715345470
MESH:D005234 Fatty Liver pirinixic acid 16.2719236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 16.2719224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4515751030 16513791 16002989 16534752 16611131
MESH:D005315 Fetal Diseases Valproic Acid 4.5416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.818888407 18558336
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.1318705752
MESH:D005756 Gastritis Acetaminophen 3.3316983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6116452187
MESH:D005909 Glioblastoma Doxorubicin 3.1317150277
MESH:D005910 Glioma Fluorouracil 2.7316145905
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.1615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1618337622 15102660 15162350
MESH:D006331 Heart Diseases Doxorubicin 3.2516879835 16707910 16144979 16244372 14766674 17875725 18674790 16330681 16495754 17888722 18006777 16244371 12587719
MESH:D006333 Heart Failure Doxorubicin 6.3517481944
MESH:D006333 Heart Failure pirinixic acid 6.3520558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.976705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 8.406705139
MESH:D006394 Hemangiosarcoma Doxorubicin 8.4015692506
MESH:D006402 Hematologic Diseases Benzene 4.3416183116
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 2.6718467677 19772884 16221962 19176532
MESH:D006689 Hodgkin Disease Doxorubicin 3.1317606976 18501091 15147373
MESH:D006849 Hydrocephalus Valproic Acid 4.5317688650
MESH:D006930 Hyperalgesia Acetaminophen 2.4416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1014722030 12960047
MESH:D006973 Hypertension Benzene 2.9617940673
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.1416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.1416945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.0315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2617937319
MESH:D007249 Inflammation Flavonoids 2.4817296493
MESH:D007333 Insulin Resistance pirinixic acid 2.4116306350
MESH:D007674 Kidney Diseases Acetaminophen 5.4015629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 5.4015699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8516707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.9216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.9216762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Fluorouracil 10.9216985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7317184923
MESH:D007938 Leukemia Benzene 3.2218335105 14694614 15935818 17119257
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8116085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell fludarabine 4.4217802794 17296974 18587576 17658394 18172266
MESH:D007951 Leukemia, Myeloid Benzene 4.0217506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.8819478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8816294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6216239168 16943688 11408273 17157831 17334410 16221502 21278145 11903743 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.6214716833 14716496 17922224 18339082 20821823 17714472 18263696 12632512 15931870 18187930 14724832 17698563 11481614 17631135 16638106 15730626 18166357 16027843 18472094 15370692 15893842 14512876 12649538 17823541 16097048 14748882 12445418 12666154 17976157 18210741 15052691 17525996 12609069 12445421 18481824 17708605 15650968 18317297 15959796 12958196 18420326 17805973 18395095 15123356 16136751 17565644 17869086 17761835 17481882 17944888 17900296 15996030 18054572 15818738 16011737 17640975 16033810 16192424 12546737 12667390 15338365 12389079 17721639 14620537 18279442 15925388 12586293 18277467 12741479 17766677 18412020 15362042 18472332 10355542 15876570 16116963 16015684 18156304 17557913 12898905 18395914 18205269 15057751 12632514 16248980 18705752 15673190 18376398 18418968 18006644 18429990 18251166 13678700
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.6216270385 14659978 16570917 16009107 15298665 18672772 12918455 12925901 15723089 15086199 15366600 17348192 15842777 15383259 18629640 14568256 15793283 18237412 15798949 18239293 15504291 14709902 18371158 15492853 15339415 17666798 15733078 17201889 17196135 17724770 15161499 15864749 16544323 15099470 18567088 15577212 17640959 18095165 17203207 17881167 15744066 15081153 18637143 17719030 17534399 18364076 14726149 15591649 15138612 16627068 17432682 15763062 15942678 16042886 15369754 16169303 18210741 17036385 15067225 16603200 17198567 15479170 15571005 17465448 14643895
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.6216595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6215474484
MESH:D008107 Liver Diseases Acetaminophen 3.5812587719 12969438 19460945 11587558 16610002 19784758 16611625 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.5816964402 16246199 15830285 17285989 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 14.5716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.5716899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.5717457977
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 35.6510737359 11376686 10672840 14678523 16273603 18001218
MESH:D008113 Liver Neoplasms 2-nitrofluorene 35.6515890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 35.6515890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 35.6515890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 35.6519294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 35.6516712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 35.653113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 35.6515113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms Methapyrilene 35.6515890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 35.6515890375 20101389 19690152 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 35.6516377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 20.621399818 534488 6150874
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 20.628603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 20.6212562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.6215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 20.626150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 20.6216842330 17085340
MESH:D017563 Lung Diseases, Interstitial Benzene 10.2314698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.2317228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 12.1511376686
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 12.1516061637 18508827 19931552 15893417 14755239 12438228 17139156 9255578 18813816 16401635 15172992
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.1514755239
MESH:D008175 Lung Neoplasms Benzene 12.1512562636
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 12.1519555203 16061637 11884234
MESH:D008175 Lung Neoplasms Doxorubicin 12.156189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 12.1515246190
MESH:D008175 Lung Neoplasms tipifarnib 12.1516885199
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4515086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8115166399
MESH:D008223 Lymphoma Benzene 11.2817584886 17119257
MESH:D008223 Lymphoma Diethylstilbestrol 11.2815700306
MESH:D008223 Lymphoma Doxorubicin 11.2816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2315621674
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1716002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.1012562636
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 16.5711921183
MESH:D008325 Mammary Neoplasms, Experimental Benzene 16.5711921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 16.5715458769
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 16.5719682730
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 16.5716648579
MESH:D008545 Melanoma Doxorubicin 2.2416827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008654 Mesothelioma Doxorubicin 2.9217638057
MESH:D008881 Migraine Disorders Valproic Acid 2.9518803445 18765137
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1915792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3716757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.4517415656
MESH:D009101 Multiple Myeloma Benzene 3.4317119195
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.728888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9617596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.2215857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.8418551238
MESH:D009336 Necrosis 2-nitropropane 9.8412195237
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8118259882
MESH:D009369 Neoplasms Diethylstilbestrol 7.3015313581
MESH:D009369 Neoplasms Fluorouracil 7.3016928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 7.3017405874
MESH:D009401 Nephrosis Doxorubicin 4.4416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7215640375 16889571
MESH:D009421 Nervous System Malformations Diethylstilbestrol 3.8111399458
MESH:D009436 Neural Tube Defects Benzene 6.8015643154
MESH:D009436 Neural Tube Defects Valproic Acid 6.808888407 16359493
MESH:D009447 Neuroblastoma Doxorubicin 3.0915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6018514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2116436463
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.1912819281 16049721
MESH:D009784 Occupational Diseases Benzene 8.1917178637 17119257 15935809 15576619 17479406 15612468 16737584 15913788 15727169
MESH:D012516 Osteosarcoma Doxorubicin 3.8515930896
MESH:D010051 Ovarian Neoplasms Benzene 2.8612562636
MESH:D010146 Pain Acetaminophen 2.1316870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.2712384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2716929163 15113037 19003803 16500647
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8117983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3416977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8117638057
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.6717184923
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.6720603192
MESH:D011471 Prostatic Neoplasms bicalutamide 2.2317914592 15638997 19240160 18487222 19011039
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.2317136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2316888761 16868541 16729912 18437689 15749863 15897917
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2319082440 18626508
MESH:D011537 Pruritus Ethinyl Estradiol 2.9815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.1911422049 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7316160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Doxorubicin 3.8917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8619155313
MESH:D012509 Sarcoma Doxorubicin 3.7017203757 15675481 18313854 16767912 17710206 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4517846226
MESH:D012559 Schizophrenia Valproic Acid 2.0215737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 5.1818551238
MESH:D012640 Seizures Valproic Acid 5.1816876388 17978042 11044598 11738929 3137016 14763951 1511512 15475178
MESH:D012878 Skin Neoplasms Doxorubicin 2.7915692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2317203757 15625365 16767912
MESH:D013088 Spermatocele Diethylstilbestrol 10.5616709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.5616709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5219490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9212587719
MESH:D013226 Status Epilepticus Valproic Acid 4.1912833885
MESH:D013274 Stomach Neoplasms Benzene 4.5012562636
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.5016033868
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5017172411 17522103 17498489 16951190 19084572 18396642 16424979 19015929 15786421 18567086
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.5017575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013953 Thymus Neoplasms Benzene 4.6210850423
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.1217909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7016280240
MESH:D014178 Translocation, Genetic Valproic Acid 4.8917262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.183119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 10.8516049721
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 10.8515867355 1399818 15289314
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.8517306315 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 10.8517653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.318888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9710091137
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.6116175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.6116803524
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8214652134
MESH:D014594 Uterine Neoplasms Benzene 14.2312562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.2315809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.2314692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1016513791 16002989
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8917678736 17638931 16364871 17334414
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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