AutismKB 2.0

Annotation Detail for HHIP


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Basic Information Top
Gene Symbol:HHIP ( FLJ20992,FLJ90230,HIP )
Gene Full Name: hedgehog interacting protein
Band: 4q31.21
Quick LinksEntrez ID:64399; OMIM: 606178; Uniprot ID:HHIP_HUMAN; ENSEMBL ID: ENSG00000164161; HGNC ID: 14866
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1727Pancreas disease
1934Cancer
Desease Name
CARDIOVASCULAR
height
pulmonary function measures
pulmonary function
chronic obstructive pulmonary disease
DEVELOPMENTAL
Desease Name
Height
Pulmonary function
Chronic obstructive pulmonary disease
Pulmonary function measures
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of HHIP mRNAdecreases expression 16788091
C006780 bisphenol A bisphenol A affects the expression of HHIP mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HHIP mRNAaffects expression 17484886
C017180 decamethrin decamethrin results in decreased expression of HHIP mRNAdecreases expression 19017407
C014347 decitabine [decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP mRNAaffects expression|affects methylation 18559595
C014347 decitabine [[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of GLI1 mRNAaffects expression|affects methylation 18559595
C014347 decitabine [[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of PTCH1 mRNAaffects expression|affects methylation 18559595
D002117 Calcitriol Calcitriol results in decreased expression of HHIP mRNAdecreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HHIP mRNAaffects expression 20170705
C019003 methaneselenol methaneselenol results in decreased expression of HHIP mRNAdecreases expression 19625696
D012643 Selenium Selenium results in increased expression of HHIP mRNAincreases expression 18997278
D014212 Tretinoin Tretinoin results in increased expression of HHIP mRNAincreases expression 18230668
D002762 Cholecalciferol Cholecalciferol results in increased expression of HHIP mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.2016142846
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7516197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0217123778
MESH:D001943 Breast Neoplasms Calcitriol 2.0211237771
MESH:D001943 Breast Neoplasms decitabine 2.0219208741 18320071
MESH:D001943 Breast Neoplasms Tretinoin 2.0216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9515721981 16192424 15673190 16124888 16227642 3786805 15700767 10355542 18705752 16097048 16011737 16050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 18559595
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0918788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.091917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8311237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.8319215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.8316051514 16096774
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 16105132 15861022 16919318 17110522 17681005 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Selenium 10.0917936198
MESH:D003092 Colitis Tretinoin 10.0917035595
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities decamethrin 3.1819861644
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.189224671 9664655 14991402 10589399 9125849 16925845 9211117 17551590 9142499 8800419
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.087179309 19085960 19336974 17522070 15027814 21278145 3786805 4309450 7120509 16177239 11566570 7440962 15998439 15968718 10092053 2869522 6623471 9327722 3732212 16227642 6884620 10915739
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0815131321
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.6415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6412538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3319294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D005124 Eye Abnormalities Tretinoin 3.689664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1617595544 15959796 61145 12631006 16239168 12795759 16045604 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1615345470
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4018705752
MESH:D005355 Fibrosis Tretinoin 9.4017994277
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006258 Head and Neck Neoplasms decitabine 8.1419215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male decitabine 7.0217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0217937319
MESH:D007251 Influenza, Human Selenium 4.4116624496
MESH:D007299 Insect Bites and Stings decamethrin 6.0115189238
MESH:D007333 Insulin Resistance bisphenol A 3.3816393666
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0417551590 15992940
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007938 Leukemia decitabine 6.6418980019 19235587
MESH:D007938 Leukemia Tretinoin 6.6417143497
MESH:D007951 Leukemia, Myeloid decitabine 10.0317236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 10.0316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0418460780 18704418 19010910 19387464 17679729 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0419850784 16294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6818055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2416891316 16140955 17294898 17217047 19642359 17506722 19035177 15748426 17361223 19029980 17339181 16766008 16788101 16935935 19075265 12679006 17712046 17368321 17107899 17301526 16823087 16331271 17649720 19225113 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8816943688 17157831 11408273 16221502 16239168 17174718 21278145 17334410 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5315052691 17481882 15650968 18277467 15876570 18472094 18263696 17922224 18429990 12389079 15893842 12898905 18205269 12445418 12958196 14748882 15996030 15931870 12741479 15818738 20821823 17823541 18156304 12546737 11481614 17714472 13678700 16027843 12586293 18395914 18418968 17805973 12445421 17557913 12667390 15370692 17721639 15673190 15362042 17708605 18187930 18054572 17565644 15338365 18339082 16136751 17525996 15925388 16011737 18006644 16116963 16248980 17766677 16638106 17976157 14620537 15123356 18251166 18317297 16015684 18279442 12666154 10355542 14512876 15959796 17761835 14724832 12632514 17631135 18472332 16192424 17698563 12632512 15730626 17640975 18376398 16097048 12649538 18166357 18210741 18481824 14716496 17900296 17869086 17944888 18412020 18420326 16033810 14716833 15057751 12609069 18705752 18395095
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5316248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1117285989 15830285 16246199 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2719294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6912014681 15583823
MESH:D008223 Lymphoma decitabine 3.5219470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma decitabine 3.4916505122 17785578
MESH:D008545 Melanoma Tretinoin 3.4916752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009101 Multiple Myeloma decitabine 3.4418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7319157545 16882708 18608210 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.7317596541
MESH:D009369 Neoplasms decitabine 5.4019470736 19116145 17925555
MESH:D009369 Neoplasms Tretinoin 5.4016946489 16594593
MESH:D009421 Nervous System Malformations bisphenol A 10.3411399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.349125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms decitabine 5.0919331143 19259094
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0916936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.5319294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.5315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1410548101
MESH:D055728 Primary Myelofibrosis decitabine 4.9017616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7416740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7416289102 15754350 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.7417024972
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D012208 Rhabdomyosarcoma decitabine 11.4519155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.4516116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.6716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms decitabine 2.5719037991
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013964 Thyroid Neoplasms decitabine 7.6517967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7717616700 19087683
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014604 Uveal Neoplasms decitabine 13.5717785578
MESH:D014604 Uveal Neoplasms Tretinoin 13.5716752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29276
    • No data
    Releated disease ID Related disease Name
    PA447178Pulmonary Disease, Chronic Obstructive
    PA443450Asthma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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