AutismKB 2.0

Annotation Detail for SFTPC


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Basic Information Top
Gene Symbol:SFTPC ( PSP-C,SFTP2,SMDP2,SP-C )
Gene Full Name: surfactant protein C
Band: 8p21.3
Quick LinksEntrez ID:6440; OMIM: 178620; Uniprot ID:PSPC_HUMAN; ENSEMBL ID: ENSG00000168484; HGNC ID: 10802
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00217Pulmonary surfactant metabolism dysfunction
Inherited disorders of ion transport and metabolism
Genetic disorders
Desease IDDesease Name
1761Respiratory tract disease
1832Congenital abnormality
2052Infection
2120Rabies
2192Lung disease
Desease Name
respiratory distress syndrome, neonatal
IMMUNE
asthma respiratory syncytial virus
bronchopulmonary dysplasia
No data
Desease Name
Surfactant metabolism dysfunction, pulmonary, 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SFTPC proteindecreases expression 15695173
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SFTPC mRNAincreases expression 18648102
D000255 Adenosine Triphosphate Adenosine Triphosphate results in increased secretion of SFTPC proteinincreases secretion 14565945
D000255 Adenosine Triphosphate Adenosine Triphosphate results in increased secretion of SFTPC proteinincreases secretion 11704537
D000255 Adenosine Triphosphate Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]decreases reaction|increases secretion 11704537
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SFTPC mRNAaffects expression 16483693
C086232 bosentan bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
C086232 bosentan bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
C086232 bosentan bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
D003907 Dexamethasone Dexamethasone results in increased expression of SFTPC mRNAincreases expression 2539393
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SFTPC mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFTPC mRNAaffects cotreatment|increases expression 17942748
D019830 Adenosine-5'-(N-ethylcarboxamide) Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC proteinincreases secretion 14565945
D019830 Adenosine-5'-(N-ethylcarboxamide) Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC proteinincreases secretion 11704537
D019830 Adenosine-5'-(N-ethylcarboxamide) Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]decreases reaction|increases secretion 11704537
D005576 Forskolin Forskolin results in increased expression of SFTPC mRNAincreases expression 2539393
D006854 Hydrocortisone Hydrocortisone results in increased expression of SFTPC mRNAincreases expression 2539393
D015759 Ionomycin Ionomycin results in increased secretion of SFTPC proteinincreases secretion 14565945
D015759 Ionomycin Ionomycin results in increased secretion of SFTPC proteinincreases secretion 11704537
C029938 nickel sulfate nickel sulfate affects the expression of SFTPC mRNAaffects expression 12718980
C029938 nickel sulfate nickel sulfate results in decreased expression of SFTPC mRNAdecreases expression 11893692
D009569 Nitric Oxide bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
D009569 Nitric Oxide Nitric Oxide results in decreased expression of SFTPC mRNAdecreases expression 15640287
D009569 Nitric Oxide PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
D020030 Nitric Oxide Donors bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
D020030 Nitric Oxide Donors Nitric Oxide Donors results in decreased expression of SFTPC mRNAdecreases expression 15640287
D020030 Nitric Oxide Donors PD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
C007350 nitrofen nitrofen results in decreased expression of SFTPC mRNAdecreases expression 12194114
C007350 nitrofen nitrofen results in decreased expression of SFTPC mRNAdecreases expression 10751355
11588001
11076806
11057544
C007350 nitrofen nitrofen results in decreased expression of SFTPC proteindecreases expression 11588001
C007350 nitrofen nitrofen results in increased expression of SFTPC mRNAincreases expression 12904592
15764645
C007350 nitrofen Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 11588001
D026423 S-Nitroso-N-Acetylpenicillamine bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
D026423 S-Nitroso-N-Acetylpenicillamine PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
D026423 S-Nitroso-N-Acetylpenicillamine S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNAdecreases expression 15640287
C093321 PD 156707 PD 156707 inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
C093321 PD 156707 PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
C093321 PD 156707 PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 15640287
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of SFTPC protein]decreases reaction|increases secretion 11704537
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Adenosine Triphosphate results in increased secretion of SFTPC protein]decreases reaction|increases secretion 11704537
C064758 Ro 31-8220 Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein]decreases reaction|increases secretion 11704537
C022088 silicon carbide silicon carbide affects the expression of SFTPC mRNAaffects expression 14646272
C032706 sodium chlorate sodium chlorate results in decreased expression of SFTPC mRNAdecreases expression 12922982
D013726 Terbutaline ADRB2 protein promotes the reaction [Terbutaline results in increased secretion of SFTPC protein]increases reaction|increases secretion 14565945
D013726 Terbutaline Terbutaline results in increased secretion of SFTPC proteinincreases secretion 14565945
D013726 Terbutaline Terbutaline results in increased secretion of SFTPC proteinincreases secretion 11704537
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFTPC mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased secretion of SFTPC proteinincreases secretion 14565945
D013755 Tetradecanoylphorbol Acetate Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SFTPC protein]decreases reaction|increases secretion 11704537
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased secretion of SFTPC proteinincreases secretion 11704537
D014212 Tretinoin Tretinoin affects the expression of SFTPC mRNAaffects expression 15328022
D014544 Uridine Triphosphate Uridine Triphosphate results in increased secretion of SFTPC proteinincreases secretion 14565945
C025643 vinclozolin vinclozolin affects the expression of SFTPC mRNAaffects expression 19015723
C017963 vinyl carbamate vinyl carbamate results in increased expression of SFTPC mRNAincreases expression 17849452
D014801 Vitamin A Vitamin A inhibits the reaction [nitrofen results in decreased expression of SFTPC mRNA]decreases expression|decreases reaction 11588001
D014801 Vitamin A Vitamin A results in decreased expression of SFTPC proteindecreases expression 11588001
C009687 wortmannin wortmannin results in decreased expression of SFTPC proteindecreases expression 15695173
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Terbutaline 7.9614610225
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9615322242 14514962 11752688
MESH:D000015 Abnormalities, Multiple Vitamin A 4.6310992263
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.0719131640 16100012 11954676 12718980
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6514692618
MESH:D000230 Adenocarcinoma vinyl carbamate 4.6517363558 16247444
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.603712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8116835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 9.8112371669
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000544 Alzheimer Disease Nitric Oxide 3.2517556102
MESH:D000686 Amyloidosis Terbutaline 5.377986221
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2211748828
MESH:D000740 Anemia Vitamin A 8.2216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5716960172
MESH:D001008 Anxiety Disorders vinclozolin 3.4319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.3517659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.3515885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.3516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 4.9416456186
MESH:D001249 Asthma Vitamin A 4.9416732791
MESH:D001321 Autistic Disorder Terbutaline 3.4616417856 17400887
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.7511289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.1616197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001943 Breast Neoplasms Nitric Oxide 2.0015631943
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0016873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.1416813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.1417426644 17377406
MESH:D019559 Capillary Leak Syndrome Terbutaline 5.599428835 11713377
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.573581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.571917145
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 4.5712371669
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 4.0916247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.557296757
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.6418922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218850075 16120746 18670907
MESH:D002386 Cataract Adenosine Triphosphate 7.4615003327
MESH:D002386 Cataract Tretinoin 7.4617460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.587505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3316129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.2116153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.789022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.7817681005 16919318 16105132 17110522 15861022 17333356 11677210
MESH:D002779 Cholestasis Nitric Oxide 17.7816919318
MESH:D002779 Cholestasis Vitamin A 17.7816175620
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Hydrocortisone 13.2715826874
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 13.2716354765 15668235 8697196 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 13.279407595
MESH:D002972 Cleft Palate Vitamin A 13.2716054864
MESH:D003092 Colitis Tretinoin 3.4517035595
MESH:D003110 Colonic Neoplasms Dexamethasone 4.0515824018
MESH:D003110 Colonic Neoplasms Vitamin A 4.0516267017 17219422
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8414669216 17141729
MESH:D003371 Cough Terbutaline 5.3019679606
MESH:D003384 Coxsackievirus Infections bosentan 6.3320392896
MESH:D019465 Craniofacial Abnormalities Dexamethasone 9.0917728286
MESH:D019465 Craniofacial Abnormalities Hydrocortisone 9.0917728286
MESH:D019465 Craniofacial Abnormalities nitrofen 9.0911405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.0915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.0917551590 9125849 8800419 9664655 10589399 9224671 9142499 14991402 16925845 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin A 9.0910992263
MESH:D003456 Cryptorchidism vinclozolin 4.0914966744
MESH:D015140 Dementia, Vascular Nitric Oxide 5.6917556102
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 10.2011298694 11906362 8970840 2524372 8156756 18759878 14531868 12868966
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 10.2012438553
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 10.2016780908 16823706 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.252952479 3621924
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4316506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003967 Diarrhea Dexamethasone 7.787237001
MESH:D003967 Diarrhea Hydrocortisone 7.787237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.4316192314 9653073 6679447 7440962 9328219 18289764 9022650 6482804 18692083 1440618 11289319 18648102 8291058
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5416146918
MESH:C538011 Eales disease Vitamin A 5.359068938
MESH:D004480 Ectromelia Vitamin A 5.5516054864
MESH:D004485 Eczema Dexamethasone 4.2112438553
MESH:D004487 Edema Dexamethasone 10.2419703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2412711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.2416716910 8273558 11698051 9599246 7812673 15177302 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9412538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.043581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1911564622
MESH:D005124 Eye Abnormalities Tretinoin 8.199664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.5815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005327 Fetal Resorption Vitamin A 5.1016054864
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.756705139
MESH:D005355 Fibrosis Terbutaline 13.4815467267
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4820067830
MESH:D005355 Fibrosis Tretinoin 13.4817994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0316417039
MESH:D005909 Glioblastoma Tretinoin 2.8417312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.797505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006261 Headache Nitric Oxide 4.9111554966 11284996
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006330 Heart Defects, Congenital nitrofen 14.9516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.9511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 14.959664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin A 14.9516080930 10992263
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.266705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6412621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 10751355
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 9.337520565
MESH:D006548 Hernia, Diaphragmatic nitrofen 9.3316863852 12194112 10370017 15756563 10359170 16490937 12746050 15136996 17618886 15793718 7576705 11076806 11584395 12505043 10370016 8863223 9859898 12904592 12407540 7520565 15764645 15707848 15578192 10898224 10646786 10898222 9698600 18280292 9473106 17270546 10541330 7760232 12021965 16720372 15185205 11685700 11057544 17245593 16292651 12759764 16080930 11409163 16473863 18958481 12547725 9575882 11588001 15088113 11329586 18280291 9476886 11051153 10693666
MESH:D006548 Hernia, Diaphragmatic Vitamin A 9.3316877224 16292552 16863852 16490937 15707848 17436238
MESH:D015658 HIV Infections Vitamin A 3.6916960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3417209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7818606429 16354765 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.0116870215
MESH:D006940 Hyperemia Nitric Oxide 5.3511156591
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6815034207
MESH:D006973 Hypertension Dexamethasone 4.9117042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9118670907 18850075
MESH:D006976 Hypertension, Pulmonary bosentan 8.4916219361
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 8.4915838368
MESH:D006985 Hyperventilation Terbutaline 5.8110895896
MESH:D006986 Hypervitaminosis A Vitamin A 5.9016054864
MESH:D007008 Hypokalemia Terbutaline 5.8317292646
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D054990 Idiopathic Pulmonary Fibrosis marker/mechanism
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0917937319
MESH:D007248 Infertility, Male vinclozolin 6.0916467254
MESH:D007249 Inflammation Dexamethasone 7.6411099482 8960868
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6412878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 7.6415177302 7562506 7812673 8273558 11698051
MESH:D007410 Intestinal Diseases Nitric Oxide 9.2510210152 11713966 11574821
MESH:D007410 Intestinal Diseases Tretinoin 9.2517994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.5515955940
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.758074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1517551590 15992940
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.766582329
MESH:D007896 Leishmaniasis Nitric Oxide 4.4417218153
MESH:D053609 Lethargy Terbutaline 6.0510895896
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.2612970779
MESH:D007938 Leukemia Tretinoin 6.2617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0316294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9819225113 17339181 16935935 17361223 19029980 19035177 16891316 16331271 16766008 17107899 19075265 17217047 17506722 17294898 12679006 16823087 17301526 16140955 17368321 15748426 16788101 17649720 19642359 9834237 17712046
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.889224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.8816054864
MESH:D008103 Liver Cirrhosis Vitamin A 3.7316256175
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.7416718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7418397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 4.7416248980
MESH:D008107 Liver Diseases Vitamin A 3.0916175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.9016762690
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.6316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.986587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.9812151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 8.9817113696
MESH:D008171 Lung Diseases nitrofen 7.6517245593 9614859 9859898 16863852
MESH:D008171 Lung Diseases Vitamin A 7.6516863852
MESH:D055370 Lung Injury Nitric Oxide 4.4711395602
MESH:D008175 Lung Neoplasms Dexamethasone 4.7015824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7011884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 4.7011807781
MESH:D008175 Lung Neoplasms vinyl carbamate 4.7011134547 16247444 12117777 11195469 15824018 14755239 15172992 16885199 17363558 12765245 17361011 17163412 12438228
MESH:D008223 Lymphoma Nitric Oxide 4.1016166326
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.198985016
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Tretinoin 1.9116752155
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D008881 Migraine Disorders Nitric Oxide 4.1011701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.8611304026 14659530
MESH:D009101 Multiple Myeloma Dexamethasone 7.1716118317 15867202 15744524
MESH:D009101 Multiple Myeloma Vitamin A 7.1716374440
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.049809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.363581430
MESH:D009369 Neoplasms Tretinoin 2.2916946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.689125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.276679447
MESH:D009436 Neural Tube Defects Tretinoin 11.279142499
MESH:D009436 Neural Tube Defects Vitamin A 11.2717400914
MESH:D007752 Obstetric Labor, Premature Terbutaline 5.8514998686
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.194026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.753988306
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 4.9516211241
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9516936753
MESH:D010146 Pain Tretinoin 2.7016870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.1915976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.547296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.5418922899 12065085 18404319 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.206228378
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.0718573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4021297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6111399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6119015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.6718220299
MESH:D011472 Prostatitis vinclozolin 4.6718629315
MESH:D011507 Proteinuria Tretinoin 3.3616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0516919318 15861022
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D011654 Pulmonary Edema Terbutaline 5.2510903255
MESH:D011658 Pulmonary Fibrosis silicon carbide 5.0114580898
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.8818379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Terbutaline 8.882878809
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5416877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.183692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8616283617 16116481
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.199673227
MESH:D012772 Shock, Septic Terbutaline 5.233431524
MESH:D012871 Skin Diseases Vitamin A 3.2918709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7816192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.788330346 18404319 11807781 12065085 8985016
MESH:D012878 Skin Neoplasms Tretinoin 8.7816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013272 Stomach Diseases Dexamethasone 4.0615472012
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Dexamethasone 7.0215138204
MESH:D013276 Stomach Ulcer Nitric Oxide 7.0215138204
OMIM:265120 SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 1 marker/mechanism
OMIM:610913 SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 marker/mechanism
MESH:D013610 Tachycardia Terbutaline 5.2510895896
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.486582329 1399818 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 6.4817045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.5616051514
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.188074119
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3416752155
MESH:D014605 Uveitis Dexamethasone 4.551336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020301 Vasospasm, Intracranial Nitric Oxide Donors 5.8819057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3015869587 14671159
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0316960172 16175781 16146918
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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