AutismKB 2.0

Annotation Detail for CDH22


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Basic Information Top
Gene Symbol:CDH22 ( C20orf25,MGC39564,dJ998H6.1 )
Gene Full Name: cadherin 22, type 2
Band: 20q13.12
Quick LinksEntrez ID:64405; OMIM: 609920; Uniprot ID:CAD22_HUMAN; ENSEMBL ID: ENSG00000149654; HGNC ID: 13251
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDH22 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of CDH22 mRNAaffects cotreatment|affects expression 18636392
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of CDH22 mRNAincreases expression 17187413
D019833 Genistein Genistein results in decreased expression of CDH22 mRNAdecreases expression 17341692
D008770 Methylnitrosourea Methylnitrosourea results in decreased expression of CDH22 mRNAdecreases expression 17341692
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of CDH22 mRNAaffects cotreatment|affects expression 18636392
D014415 Tunicamycin Tunicamycin results in decreased expression of CDH22 mRNAdecreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of CDH22 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury Chlorine 4.5820601635
MESH:D000230 Adenocarcinoma Genistein 5.0111473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 5.0115688392 15113128
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.8710737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.396705139
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6015570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001943 Breast Neoplasms Genistein 2.5916541309 17200150 16873071
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.5911306469 14633655 16253758
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8715516495 19059883 18315731 14754758 18417511 17626835 16777450
MESH:D002100 Cachexia Ozone 5.0816183385
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 3.5510737359 17761372 3581430 3084413 6705139
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.5516924424
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract Methylnitrosourea 4.1212484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 3.957505956 2727394
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5316647724
MESH:D004417 Dyspnea Chlorine 5.0020016425
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.5711555667
MESH:D005739 Gas Poisoning Chlorine 5.3920016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D005910 Glioma Methylnitrosourea 3.649825942
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.696705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.656705139
MESH:D007248 Infertility, Male Methylnitrosourea 7.667193160
MESH:D007248 Infertility, Male vinclozolin 7.6616467254
MESH:D007938 Leukemia Genistein 3.1318980019 17468513
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.3715526292
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 3.2018001218 10737359 10672840 14678523 16273603 11376686
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 3.661399818 534488 6150874
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.7716080182
MESH:D008171 Lung Diseases Ozone 3.538266340 19066396
MESH:D055370 Lung Injury Ozone 4.1520417186
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 3.8611376686
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.8618062963
MESH:D008175 Lung Neoplasms Ozone 3.868597069 7614698
MESH:D008223 Lymphoma Methylnitrosourea 4.1811418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.0314633661
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.9512929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.9516051031 10767621 16944150 16619500 14633655 15688392 17020996 15313902 10838139 15113128 14999141 17131329 11807958 12931682 19196723 11751437 16827153
MESH:D008679 Metaplasia Ozone 5.4810496685
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009369 Neoplasms Methylnitrosourea 3.4015533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.7812696579
MESH:D009421 Nervous System Malformations Genistein 4.3116427766
MESH:D009442 Neurilemmoma Methylnitrosourea 5.8211555667
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6619005980
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4316965848
MESH:D010538 Peritonitis Ozone 4.4416369182
MESH:D011014 Pneumonia Ozone 4.7318007984 18929643 18381685
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2319015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Genistein 3.6116925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6115682402 12376480
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D012120 Respiration Disorders Chlorine 5.5918579056
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.5918172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.8211555667
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7018593901 15930296 16257854
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.5711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.107505956 3078959
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 3.3415289314 1399818 15867355
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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