AutismKB 2.0

Annotation Detail for ARAP3


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Basic Information Top
Gene Symbol:ARAP3 ( CENTD3,DRAG1,FLJ21065 )
Gene Full Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Band: 5q31.3
Quick LinksEntrez ID:64411; OMIM: 606647; Uniprot ID:ARAP3_HUMAN; ENSEMBL ID: ENSG00000120318; HGNC ID: 24097
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
Pathway IDPathway Name
Signaling by Rho GTPases
Pathway IDPathway Name
200098Class I PI3K signaling events
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2087Bacterial infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of ARAP3 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of ARAP3 mRNAaffects cotreatment|decreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1811473722
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.4117868700
MESH:D001930 Brain Injuries Progesterone 5.0215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Estradiol 2.1716675129 17261762 12948864 18497071 17289903 19861407 17018787 14630087
MESH:D001943 Breast Neoplasms Progesterone 2.1717614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.3516111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.8016924424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 3.0918566989
MESH:D003928 Diabetic Nephropathies Estradiol 3.8819279558
MESH:D003929 Diabetic Neuropathies Progesterone 5.2617187935
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.4517692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.2819148513 11473722 18566989
MESH:D004715 Endometriosis Progesterone 4.2716134523
MESH:D006558 Herpes Genitalis Estradiol 6.1015709030
MESH:D019584 Hot Flashes Estradiol 4.8217088409
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 5.1715869954
MESH:D007249 Inflammation Progesterone 2.8115869954
MESH:D007333 Insulin Resistance Estradiol 3.2616393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.8315618244
MESH:D007680 Kidney Neoplasms Estradiol 3.4115610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6914659978 14716833
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 7.0411807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.0417203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.5519453300
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.6616810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.6217289903
MESH:D009421 Nervous System Malformations Estradiol 4.3216427766 11399458
MESH:D010051 Ovarian Neoplasms Estradiol 5.2619401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.2617393432 16525653
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.4420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0116740699
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9818045962
MESH:D013119 Spinal Cord Injuries Progesterone 5.1715862959 16503802
MESH:D013978 Tibial Fractures Estradiol 5.7619048282
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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